Published On By Rachel Nall

Ligandrol LGD 4033 side effects warnings

Ligandrol is a novel non-steroidal oral selective androgen receptive modulator (SARM), a new class of research drugs intended to help prevent muscle wastage and increase bone density by targeting specific receptors in your muscle and bone tissues.

It claims to mimic the effects of testosterone but with limited side effects. Ligandrol is not approved by the FDA and is banned in professional sports by the WADA and NCAA. It is known to cause several health problems, like liver damage, testicular shrinkage, and an increased risk of heart attacks.

While Ligandrol (LGD-4033) promises to help attain a shredded physique, it does so at the cost of your health. This Ligandrol review discusses the benefits, side effects, and safer alternatives to Ligandrol.

What Is Ligandrol?

Ligand Pharmaceuticals created Ligandrol, and then this substance came under Viking Therapeutics’ development.

This non-steroidal oral SARM has gained popularity among bodybuilders for its ability to prevent muscle loss and increase bone density. Here are four reasons why:

  1. Muscle Preservation: Ligandrol binds selectively with androgen receptors in muscle and bone tissues, mimicking the effects of testosterone boost without converting it into DHT or estrogen. It helps cut fat while preserving lean muscle mass, allowing you to maintain gains during the cutting phases.
  2. Increased Strength: By stimulating protein synthesis by enhancing nitrogen retention, Ligandrol promotes the growth of lean muscle tissue, leading to increased strength gains. You can notice improved lifting capacity and enhanced endurance during workouts with consistent use.
  3. Medical Applications: Ligandrol has been tested for its potential use in conditions such as cachexia (muscle wasting), cancer-related fatigue, and enlarged prostate.

How Does Ligandrol (LGD 4033) Work?

Ligandrol, also known as LGD-4033, selectively binds with receptors in bone and muscle tissues, mimicking the effects of testosterone. This mechanism of action allows it to increase lean muscle mass, strength, and recovery times while reducing muscle wastage and bone breakdown.

To better understand Ligandrol’s impact, let’s take a closer look at its effects on different aspects of our bodies:

  1. Muscle Tissue: Ligandrol stimulates the growth of lean muscle mass by activating androgen receptors in muscle cells. It increases protein synthesis and decreases protein degradation, enhancing muscle development.
  2. Bone Tissue: By binding with receptors in bone tissues, Ligandrol promotes bone formation and reduces bone breakdown. It increases bone mineral density and triggers new bone formation, making it ideal for individuals with osteoporosis or those recovering from fractures.

To visualize these effects more clearly:

Effects Muscle Tissue Bone Tissue
Lean Muscle Increases N/A
Strength Increases N/A
Recovery Times Decreases N/A
Maintenance Easier with Helps maintain
of Gains lower dosages bone mass

Ligandrol targets specific tissues without converting into DHT or estrogen, which reduces the chances of unwanted conditions like water retention and bloating.

Ligandrol Benefits

  1. Increase Lean Muscle Mass

    Ligandrol claims to increase muscle mass radically in a short time. Here are three ways in which Ligandrol promotes the growth of lean muscle mass:

    1. Muscle Protein Synthesis: Ligandrol activates the androgen receptors in your muscle tissues, stimulating protein synthesis. By enhancing muscle protein synthesis, Ligandrol helps you build lean muscle mass.
    2. Increased Nitrogen Retention: Nitrogen is an essential amino acid that builds proteins. Ligandrol enhances nitrogen retention in your muscles, ensuring a positive nitrogen balance.
    3. Improved Recovery: Intense workouts can cause microscopic damage to your muscles. The recovery phase is when your muscles repair themselves and grow stronger. Ligandrol speeds up this recovery process by reducing inflammation and promoting the regeneration of healthy muscle tissue.

  2. Promote Fat Loss

    When using Ligandrol, your body may become more efficient at burning fat. It’s because Ligandrol enhances your metabolism, allowing you to burn calories more effectively. Ligandrol helps prevent muscle wastage during the cutting phases, ensuring you maintain lean muscle mass as you lose weight.

    It is thought to increase strength and stamina, allowing you to push harder during workouts and burn more fat. Some also claim that it can cause an increase in energy levels while taking Ligandrol, which can further support fat loss efforts.

Dosage – Ligandrol (LGD-4033)

Ligandrol is an SARM and is not recommended for therapeutic use. There is no reliable information regarding the dosage of Ligandrol. The WADA and NCAA ban Ligandrol due to its performance-enhancing effect similar to steroids. The FDA does not approve it for human use, and cannot be marketed as a dietary supplement or drug. It is an investigational drug known to have several long-term side effects on the user, including liver damage, heart attack, and infertility.

The FDA claims that there are adverse effects from Ligandrol usage, like liver toxicity, disturbed blood lipid levels, stroke, and chances of a heart attack.

My Consumption Results With Ligandrol

As someone passionate about fitness and bodybuilding, I was looking for a supplement to help me gain lean muscle mass and increase strength without the negative side effects of topical steroids. That’s when I came across Ligandrol, a popular SARM in the bodybuilding community.

I decided to give it a try and incorporated Ligandrol into my daily routine. It helped my weight increase, and my strength improved noticeably by week three. I also experienced enhanced vascularity and muscle pumps during workouts. I was desperate for results and was experiencing frequent strength gains, which were quite exciting for me, but soon, it started troubling my health.

However, as the days progressed, I started to face trouble sleeping and felt aggressive and lost during the day.

I started having problems in my sexual life due to a decrease in my sex drive.

I sought the advice of a trusted doctor who reported that my reproductive system was not functioning correctly and my liver health had declined significantly. Ligandrol had several adverse effects on my health, so I stopped its use and was advised to rest for a few weeks.

Also See: PrimeGENIX DIM 3X Reviews: Ingredients, Results, Side Effects In Men And Warnings

Side-Effects Of Using Ligandrol

Ligandrol leads to testosterone suppression. It means your natural testosterone production may decrease during and after your cycle. Other life-threatening problems related to using SARMs include liver injury, heart attack, psychosis, and testicular shrinkage. Here are some milder side effects of Ligandrol.

  1. Headache

    Headaches can be a common occurrence when introducing Ligandrol into your routine. They are often temporary and may subside. However, suppose you experience severe or persistent headaches. In that case, consulting with a healthcare expert is essential to ensure no underlying issues.

  2. Nausea

    If you’re experiencing nausea while using Ligandrol, addressing this potential side effect and prioritizing your well-being is essential. Nausea can be an uncomfortable symptom affecting your daily activities and overall efficiency.

  3. Fatigue

    Despite its claimed energy-boosting effect, several users report persistent fatigue in their daily lives.Fatigue is the constant lack of energy or burnout one may feel for an extended period of time.

  4. Testosterone Suppression

    Testosterone suppression occurs upon Ligandrol consumption as it can inhibit your body’s natural testosterone production process. The ingestion of Ligandrol disturbs the natural production of androgens that fill the body with androgens.

    Testosterone is the primary male hormone responsible for developing and maintaining the reproductive organs, muscle growth, and mood regulation. Its low levels can harm your health and lead to several disabilities. However, if you choose to stay with Ligandrol, it can increase the risk of stroke, heart attack, and liver damage, to name a few major problems.

Safer Alternatives for Ligandrol

Ligan 4033 could be a safer alternative to Ligandrol. One of the biggest concerns with Ligandrol is its potential to suppress testosterone levels. It can have an adverse impact on your well-being. Ligan 4033 contains all-natural ingredients that synergistically lift your natural testosterone levels without negative impacts. As per the official website, Ligan 4033 could be a safe and natural alternative to Ligandrol. Ligan 4033 is marketed as a natural formula that can lift T-levels and increase energy levels. You must complement it with proper exercise and a nutritious diet that ensures proper nutrition of your muscle cells.

Frequently Asked Questions

  1. Are there any potential long-term side effects of using Ligandrol?
    Ligandrol is an investigational drug that the FDA does not approve. There have not been enough studies of Ligandrol’s long-term effects on humans. However, some common problems associated with SARM usage are acute liver failure, infertility, and heart attacks.
  2. Can everyone use Ligandrol?Ligandrol is an oral SARM, which the FDA does not approve. It is not legal to market it as a dietary supplement or drug. It is an investigational drug intended to prevent muscle wasting, but there’s no reliable information regarding its safety or usage.
  3. Is Ligandrol legal for use in professional sports?
    Ligandrol is not legal for use in professional sports. Please note that WADA and National Collegiate Athletic Association(NCAA) have banned Ligandrol due to its performance-enhancing properties.
  4. How long does it take to see results from using Ligandrol?
    It typically takes 3-4 weeks to start seeing results from using Ligandrol. However, it’s important to note that individual results may vary depending on factors such as diet, exercise routine, and dosage.
  5. Can Ligandrol be stacked with other supplements or medications?
    Ligandrol may be stacked with other SARMs for heightened results, but not legally. The FDA disapproves Ligandrol due to its severe side effects like liver injury, infertility, and heart attack. It is required to consult a healthcare professional before using Ligandrol.


Ligandrol is an effective SARM that claims to increase muscle gain, strength, speed, and endurance. However, there’s a reason why the FDA, WADA, and NCAA ban it. It is a potential threat to public health because of its long-term side effects, which can be everlasting. Being aware of immediate side effects such as nausea, fatigue, and low testosterone is also essential.

There are natural and safer alternatives to Ligandrol that may help you gain a better physique in a healthier fashion. Adopting a balanced diet and a relaxed lifestyle may help you balance your hormone levels naturally.

It is easy to be swayed by the lucrative benefits of SARMs like Ligandrol. However, you must remember that it can cause significant damage to your body.

  • The information in this Ligandrol review is for informational purposes only and should not be considered medical advice.
  • It is not recommended to disregard/delay seeking professional medical advice or treatment because of what you read or accessed through this review.
  • The results may vary from individual to individual.
  • It is recommended to consult your doctor for any underlying medical conditions or if you are on any prescribed medicines before using Ligandrol.

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