8 Best Supplements To Reduce Cortisol in 2025

Cortisol is a crucial hormone that can regulate your energy, metabolism, and immune function, but when levels remain too high for too long, it can negatively impact your health. Chronic stress causes excessive cortisol production, resulting in fatigue, weight gain, anxiety, poor sleep, and a weakened immune system.

Managing cortisol is essential for maintaining your overall well-being, and while lifestyle changes like proper sleep, balanced nutrition, and stress management techniques play a key role, they may not always be enough. This is where supplements can help.

Certain adaptogens, vitamins, minerals, and amino acids have been shown to support adrenal health, promote relaxation, and enhance the ability to handle your stress more effectively. With so many cortisol-lowering supplements available, choosing the right one can feel overwhelming.

In this guide, you’ll discover the 8 best supplements to reduce cortisol, how they work, and which ones might help you achieve better balance, improved well-being, and long-term stress relief.

8 Best Supplements To Reduce Cortisol

1. Live Conscious ZenWell

   

   ZenWell claims to help you reduce everyday stress, improve mental clarity, and stay focused. It contains KSM-66, a highly concentrated, full-spectrum ashwagandha root extract, and AlphaWave, a pure form of L-Theanine.

   According to the manufacturers, KSM-66® has been tested in 13 top-level clinical trials and is claimed to help your body manage stress, boost mental clarity, and fight fatigue. AlphaWave® L-Theanine is said to promote relaxation, improve sleep quality, sharpen focus, and support your immune system. Each bottle contains 30 servings, with a recommended dose of two capsules daily. ZenWell® is manufactured in the USA with globally sourced ingredients under strict cGMP standards and undergoes third-party testing for quality and safety.

   Pros

   • Helps reduce stress and anxiety with KSM-66® Ashwagandha, a well-researched ingredient.
   • Improves focus and mental clarity with a mix of Ashwagandha and AlphaWave® L-Theanine.
   • Supports relaxation and better sleep without making you feel sleepy during the day.
   • It is made in the USA under strict quality standards using ingredients from different countries.
   • Third-party testing to ensure safety and effectiveness.
   • It comes with a 365-day money-back guarantee.

   Cons

   • Results may be different for each person and take time to show.
   • Only sold on the official website, so you can’t buy it in stores.
   • One-time purchases cost more than subscription options.

2. THORNE Phosphatidylserine

   

   Thorne’s Phosphatidylserine claims to support brain health, memory, focus, and cortisol management. Each capsule contains 100 mg of phosphatidylserine isolate phospholipid, which is essential for maintaining healthy brain cell membranes and enhancing cell-to-cell communication.

   The makers state that by improving membrane fluidity, Thorne phosphatidylserine supports cognitive function, neurotransmitter production, and glucose metabolism in the brain. It is also said to have antioxidant properties that help protect brain cells from excessive free radical damage.

   The product is claimed to modulate your cortisol levels by reducing stress-induced spikes, promoting a balanced stress response. It is free from gluten and dairy but contains an ingredient derived from soy (without soy protein). Thorne also assures that it is third-party tested to ensure purity and safety, making it a suitable option for cognitive support and managing stress.

   Pros

   • Supports cognitive function by improving memory, focus, and overall brain health.
   • Reduces stress and cortisol levels by modulating stress-induced hormone spikes.
   • Enhances brain cell communication and supports neurotransmitter production
   • Provides antioxidant benefits that help protect brain cells from free radical damage
   • Third-party tested to ensure purity and safety, free from heavy metals and pesticides.

   Cons

   • Contains soy-derived ingredients, which may not be suitable for those with soy allergies.
   • The higher price point of $63 for 60 capsules may be expensive for some individuals.
   • Effects may vary from person to person, and benefits may take time to become noticeable.

3. Ritual Stress Relief

   

   The Stress Relief supplement by Ritual is claimed to help you manage stress and support your body’s natural cortisol response throughout the day. According to the makers, it uses BioSeries™ technology, a unique three-in-one tablet-in-capsule system that releases ingredients over 8 hours for continuous support.

   The company states that you get ashwagandha (80mg) to help maintain normal cortisol levels and reduce stress, l-theanine (200mg) for quick stress relief and a non-drowsy sense of calm, and saffron (28mg) to promote a positive mood.

   The BioSeries™ technology is said to work in three stages: an instant-release tablet to support your body’s peak morning cortisol levels, a 4-hour extended-release tablet, and an 8-hour extended-release tablet to provide sustained stress relief.

   Pros

   • Uses BioSeries™ technology for an 8-hour extended-release to provide continuous stress relief.
   • Contains Shoden® Ashwagandha, Suntheanine® L-Theanine, and affron® Saffron, which have been clinically tested to support cortisol balance, reduce stress, and improve mood.
   • L-Theanine helps provide quick stress relief within an hour without causing drowsiness.
   • Designed to be taken daily without concerns of dependency.
   • Ritual provides transparency by showcasing the source and supplier of each ingredient.
   • You have an option to choose from a one-time purchase or subscribe to save money with free shipping and an easy cancellation policy.
   • It comes with a 30-day money-back guarantee that can allow you to try it risk-free.

   Cons

   • Higher cost compared to some other stress relief supplements.
   • Some users may find it inconvenient to take multiple tablets instead of a single pill.
   • While ingredients are clinically studied, individual responses to stress relief supplements can differ.

4. Cortisol Manager By Integrative Therapeutics

   

   Cortisol Manager by Integrative Therapeutics claims to help you maintain balanced cortisol levels and support a healthy stress response. According to the manufacturer, Cortisol Manager contains a blend of Sensoril® ashwagandha and L-theanine to help you reduce stress, along with Magnolia, epimedium, and phosphatidylserine from soy lecithin to promote relaxation and cortisol regulation further. Since cortisol is a key hormone released by your adrenal cortex during times of stress, keeping it balanced is essential for overall well-being. The makers claim that this supplement helps stabilize cortisol levels, supporting relaxation and restful sleep.

   Pros

   • It balances cortisol levels, which may contribute to a healthier stress response.
   • It may help promote relaxation and support restful sleep.
   • The product is dairy-free, vegan, gluten-free, and vegetarian, making it suitable for various dietary needs.
   • Available in both 30-tablet and 90-tablet bottles, giving you flexibility in purchasing.

   Cons

   • Individual responses to the product can vary.
   • If you have a soy allergy or sensitivity, you may need to be cautious, as it includes phosphatidylserine from soy lecithin.
   • Some users might experience mild side effects like drowsiness, digestive discomfort, or headaches.

5. Lukaree Cortisol Supplement

   

   Lukaree Cortisol Supplement claims to be a cortisol reducer and detox manager that can help you balance cortisol levels, relax, sleep better, and improve cognitive function. The makers claim that it can support you in managing stress, boosting your immune system, maintaining a healthy metabolism, and promoting adrenal health. Ashwagandha and St. John’s Wort in Lukaree Cortisol Supplement can help you reduce stress and improve your mood, while L-Theanine and Chamomile promote relaxation and restful sleep. Phosphatidylserine and Rhodiola are said to support your brain function, energy, and mental clarity. Lukaree Cortisol Supplement could also strengthen your immune system and bone health. It has magnesium glycinate that may help with relaxation.

   Pros

   • Supports stress relief by lowering cortisol levels and reducing stress.
   • Promotes relaxation and sleep by aiding in relaxation and improving sleep quality.
   • Boosts cognitive function to provide mental clarity.
   • Vitamins C and D3 are included to support immune health.
   • Helps with metabolism and weight management.
   • Free from gluten, soy, nuts, dairy, sugar, chemicals, preservatives, and fillers

   Cons

   • Results may vary, as individual responses may differ.
   • Requires consistent use.
   • Potential allergic reaction.

6. LES Labs Cortisol Health

   

   Cortisol Health by LES Labs claims to support your adrenal function, promote balanced cortisol levels, and help you manage stress. The company claims that it encourages relaxation, improves sleep quality, and reduces feelings of anxiety by regulating your body’s stress response. The Cortisol Health formula includes a blend of ingredients such as ashwagandha, magnesium, phosphatidylserine, magnolia bark extract, and Rhodiola rosea, each of which is stated to support healthy adrenal function and promote a sense of calm. The manufacturers also claim that by regulating cortisol, the hormone responsible for stress, Cortisol Health may help you maintain a healthy weight, improve focus, and support overall well-being. This supplement is made in the USA with high-quality ingredients sourced from around the world and is extensively tested for safety and effectiveness.

   Pros

   • Designed to regulate cortisol levels, promoting relaxation and reducing stress.
   • It may help with improved sleep without feeling groggy in the morning.
   • Contains ashwagandha, magnesium, Rhodiola rosea, and phosphatidylserine.
   • Balanced cortisol levels could help prevent stress-related weight gain.
   • It may make you feel calmer, more present, and better able to handle daily stress.
   • It comes with a 60-day satisfaction guarantee.

   Cons

   • Effects may differ from person to person.
   • Works best when taken consistently over time.
   • Promotes relaxation but does not induce sleep like a sleeping pill.
   • Some users may experience digestive discomfort or drowsiness.

7. Ashenutri 10-in-1 Cortisol Supplement

   

   Ashenutri 10-in-1 Cortisol Supplement claims to support stress management, hormone balance, and overall well-being. This vegan formula includes a blend of essential nutrients such as Vitamin B6, Vitamin C, Omega-3 fatty acids, and Magnesium Glycinate, which contribute to mental and physical health. It features 20:1 ashwagandha root extract and Rhodiola rosea, known for helping the body adapt to stress and promoting resilience. L-Theanine is added for its calming effects, while Phosphatidylserine from sunflower lecithin supports cognitive function, memory, and mental clarity. Magnolia Bark Extract in Ashenutri 10-in-1 Cortisol Supplement further enhances relaxation and energy levels.

   Pros

   • Combines essential vitamins, minerals, and adaptogens to support stress relief and hormone balance.
   • Enhances cognitive function and mood stability with Phosphatidylserine and L-Theanine.
   • Made with natural, vegan-friendly ingredients and free from artificial additives.
   • Produced in the U.S. under strict safety and quality standards.

   Cons

   • Effects may vary, and some users might take longer to experience noticeable benefits.
   • It contains sunflower lecithin, which may not be suitable for those with allergies.
   • Some users may experience mild side effects like drowsiness, digestive discomfort, or headaches.

8. Cortisol Calm By Pure Encapsulations

   

   Cortisol Calm by Pure Encapsulations is claimed to help maintain a healthy cortisol response, promote relaxation, and support emotional well-being during times of occasional stress. The product features a blend of herbal extracts and vitamin D, including Sensoril® ashwagandha extract, Rhodiola, magnolia, and L-theanine, which are all promised to support healthy sleep, mood, and cognitive function. The ingredients are also said to help manage stress, calm the body, and support overall emotional balance. Pure Encapsulations emphasizes that these effects are backed by science, and their product is free from allergens like wheat, soy, dairy, eggs, tree nuts, and artificial additives.

   Pros

   • The product is free from common allergens such as wheat, soy, dairy, eggs, tree nuts, and artificial additives.
   • It is said to promote a positive mood, relaxation, and improved cognitive function.
   • The formula is promised to help with stress management and foster a calm, relaxed state.
   • It may help maintain a healthy cortisol response.
   • It is free from GMOs.

   Cons

   • At $90 for 120 capsules, it may be considered expensive compared to other similar products.
   • The product’s effectiveness may not be the same for everyone.

Why Reducing Cortisol Is Important for Health?

Your adrenal glands produce cortisol steroid hormone, in response to stress. It is critical for the hypothalamic-pituitary-adrenal (HPA) axis and regulates essential functions like glucose metabolism, blood pressure, immune response, and inflammation.

While short-term cortisol release helps you handle stressful situations, consistently high levels due to chronic stress can disrupt your body’s natural balance and negatively impact your health.

Excess cortisol raises blood sugar levels by promoting gluconeogenesis in the liver, which can lead to insulin resistance, excessive weight gain, and an increased chance of developing a risk of type 2 diabetes. It also weakens your immune system by reducing white blood cell activity and antibody production, making you more susceptible to infections and autoimmune conditions.

High cortisol levels can also interfere with neurotransmitters like dopamine and serotonin, increasing your risk of anxiety, depression, and cognitive decline while also damaging the hippocampus, which affects memory and learning.

Your hormonal balance may also suffer, as cortisol disrupts testosterone, estrogen, and thyroid function, potentially leading to reproductive issues, fatigue, and metabolic disorders.

Elevated cortisol increases blood pressure and cholesterol levels, putting you at an increased risk for heart disease. Since cortisol follows a circadian rhythm, chronic stress can disturb this cycle, leading to poor sleep, exhaustion, and further hormonal imbalances.

To maintain your overall well-being, it’s essential to manage cortisol levels through lifestyle changes, stress-reducing techniques, and targeted supplementation. Maintaining cortisol levels can help with your body’s natural functions and reduce the risk of long-term health complications.

Side Effects Of Supplements To Reduce Cortisol

1. Might Cause Allergic Reactions

   Although rare, some natural ingredients in cortisol-lowering supplements may trigger allergic reactions. You could experience symptoms like itching, skin rashes, swelling, or even difficulty breathing. If you have any known allergies to herbs or plant-based ingredients, it’s a good idea to check its ingredient list carefully before taking the supplement.

2. Could Disrupt Sleep Patterns

   While many cortisol-reducing products support better sleep, some may have the opposite effect. Adaptogens like Rhodiola have energizing properties, which could cause restlessness or trouble falling asleep if taken too late in the day. Phosphatidylserine, which helps regulate cortisol levels, might also interfere with your sleep if you take a higher-than-recommended dose.

3. May Affect Blood Sugar Levels

   Some cortisol-reducing supplements, including ashwagandha and magnesium, might influence your blood sugar levels. If you have insulin resistance or diabetes, this could be beneficial, but it may also lead to unexpected drops or fluctuations in blood sugar. Keeping track of your levels and discussing its use with a doctor can help prevent any issues.

4. Might Disrupt Hormonal Balance

   Since cortisol is part of your endocrine system, products that lower it could also impact other hormones. For example, ashwagandha might affect thyroid hormone levels, and overusing cortisol-lowering supplements may disrupt testosterone or estrogen balance. If you have a hormone-related condition, you may want to talk to a health expert before taking these supplements to reduce your cortisol.

5. Could Interact With Medications

   Cortisol-lowering supplements might interact with medications you are already taking, such as blood pressure drugs, antidepressants, or immune-suppressing medications. For example, ashwagandha may lower blood pressure, which could be a concern if you’re already on antihypertensive drugs.

6. Might Lead To Fatigue

   Some supplements that help with relaxation, such as ashwagandha and phosphatidylserine, may make you feel drowsy or overly fatigued. You might notice this effect more if you take them in the morning or during the day. If this happens, consider adjusting the timing of your supplement intake and try taking it in the evening instead.

7. May Cause Digestive Discomfort

   You might experience mild digestive issues like nausea, bloating, or diarrhea when taking cortisol-lowering supplements, especially adaptogens like ashwagandha and Rhodiola. This could happen if you take them on an empty stomach or in high doses. Magnesium, another common ingredient, may also lead to loose stools if consumed excessively. To reduce the chances of stomach discomfort, try starting with a lower dose and taking your supplements with food.

How To Choose The Right Cortisol Supplement

1. Look For Key Ingredients Used

   When choosing a supplement to reduce cortisol, you should focus on ingredients that are scientifically studied for their ability to regulate stress and support adrenal function. Some of the most effective ingredients include ashwagandha, Rhodiola Rosea, phosphatidylserine, magnesium, L-theanine, and essential vitamins like vitamin C and B-complex. Ashwagandha is a powerful adaptogen that balances the hypothalamic-pituitary-adrenal (HPA) axis, decreasing cortisol levels and improving resilience to stress. Rhodiola Rosea enhances energy levels, reduces fatigue, and supports the body’s ability to manage stress. Phosphatidylserine is particularly effective for lowering cortisol after intense exercise, helping to regulate the body’s stress response. A cortisol supplement that has magnesium may play a crucial part in calming your nervous system and preventing stress-induced cortisol spikes.

2. Choosing A Supplement Based On Your Needs

   Different supplements for reducing cortisol offer unique benefits, so selecting the right one depends on your specific health goals. If you are experiencing daily stress and anxiety, ashwagandha and L-theanine could be suitable for promoting relaxation. If you struggle with poor sleep and nighttime cortisol spikes, magnesium and phosphatidylserine can help regulate your sleep cycle and promote deep, restful sleep. For those experiencing adrenal fatigue and low energy due to prolonged stress, Rhodiola Rosea and B vitamins can restore adrenal function and improve overall vitality. If you engage in high-intensity exercise and want to prevent cortisol from hindering recovery, phosphatidylserine can help reduce post-exercise cortisol levels.

3. Ensuring Quality And Effectiveness

   Not all cortisol-lowering supplements are of the same quality, so it’s important to choose a product that meets high safety and efficacy standards. Look for cortisol products that have undergone third-party testing, as certifications from organizations like NSF or USP verify purity and potency. Transparent ingredient labeling is also essential and avoid proprietary blends that do not disclose exact ingredient amounts, as this could make it difficult to determine their effectiveness. Stay away from supplements containing artificial additives, preservatives, or excessive stimulants like caffeine, which may counteract the stress-reducing benefits.

4. Selecting The Right Form Of Supplement

   Cortisol-reducing supplements come in different forms, and choosing the right one depends on your preferences and lifestyle. Capsules and tablets offer convenience with pre-measured doses that make supplementation simple. Powders, particularly for ingredients like magnesium and ashwagandha, can be mixed into water or smoothies for flexible dosing. Some herbs, such as Rhodiola Rosea, are also available in liquid extracts, which may be absorbed more quickly.

Frequently Asked Questions

1. Does Caffeine Interfere With Cortisol-Lowering Supplements?
   Caffeine can increase cortisol levels, causing jittery sensations and restlessness. Try to reduce its intake, as it may enhance the effectiveness of these supplements.
2. How Does Hydration Affect Cortisol Levels?
   Dehydration can increase cortisol levels, so staying hydrated may enhance the effectiveness of cortisol-lowering supplements.
3. Can I Take Cortisol-Lowering Supplements With Other Medications?
   Some supplements may interact with medications, especially those for blood pressure, anxiety, or thyroid conditions. Always consult a doctor before combining them.
4. Can These Supplements Replace Stress Management Techniques?
   No, supplements work best when combined with healthy lifestyle habits like sleep, exercise, and stress reduction techniques such as meditation or deep breathing.
5. Can Supplements To Reduce Cortisol Completely Eliminate Stress And Cortisol Spikes?
   Supplements cannot eliminate stress or cortisol spikes, as these are natural responses of your body. However, they can help regulate cortisol production, helping your body to adapt to stress and prevent chronically high levels.

Conclusion

Keeping your cortisol levels balanced is important for your overall health. When stress lasts too long, it can slow down the metabolism, weaken your immune system, and affect your mood. While getting enough sleep, eating a healthy diet, and managing stress are key, supplements can also help your body handle stress better.

However, cortisol supplements are not a one-size-fits-all solution. How well they work depends on your health, lifestyle, and what’s causing your stress. To get the most benefits, combine them with healthy eating, regular exercise, and stress-relief practices like meditation or deep breathing. Following a complete approach can lower stress, improve your well-being, and make you feel better in the long run.