8 Best Glutathione Supplements in 2025

Glutathione is known as an antioxidant that your body naturally produces, and it can lower inflammation, support the immune system, and assist with detoxification. However, factors like aging, pollution, stress, and a poor diet may lower glutathione levels over time.

Glutathione supplements claim to help restore these levels, which may translate to better liver health, immunity, and metabolism. They may also provide skin-brightening effects, as they could help suppress melanin production and even out skin tone.

However, the effectiveness of glutathione supplements might depend on factors like dosage, body chemistry, age, diet, and overall health.

In this article, we discuss the 8 best glutathione supplements based on how well they work, their absorption, benefits, features, delivery system, and more. The article also explores the potential drawbacks associated with taking glutathione supplements.

8 Best Glutathione Supplements

1. Codeage Liposomal Glutathione

   

   As per the official site, Codeage Liposomal Glutathione contains 500 mg of Setria® L-glutathione and a 350 mg phospholipid complex made from non-GMO sunflower oil and lecithin per 2-capsules serving.

   Setria® L-glutathione is a patented antioxidant that may help your body lower free radical damage. Such effects might help boost your immune system and protect bodily cells from harm. It might also help improve skin health and promote a brighter, more even skin tone.

   Codeage Liposomal Glutathione offers a vegan and non-GMO formula that does not contain allergens like dairy, soy, preservatives, artificial flavors, or gluten. It is also made in a cGMP-certified facility in the USA using premium-quality ingredients from around the world.

   However, Codeage Liposomal Glutathione may trigger side effects like bloating, stomach discomfort, or skin irritation. Long-term use of glutathione might reduce zinc levels in the body, which might lead to symptoms like hair loss, diarrhea, weak immunity, and slower wound healing.

   Pros

   • It uses Setria®, a patented and effective form of glutathione.
   • Liposomal delivery may help the body absorb glutathione more effectively.
   • It might promote a brighter, more even skin tone.
   • It meets USP monograph specifications for safety and reliability.
   • Does not contain dairy, soy, gluten, preservatives, and artificial flavors.
   • It uses sunflower-based lecithin instead of soy.
   • Made in a cGMP-certified USA facility.

   Cons

   • It might cause irritation or skin breakouts.
   • The liposomal formulation may degrade if stored improperly.
   • Its independent lab testing status remains unclear.

2. Rho Nutrition Liposomal Glutathione

   

   Rho Nutrition Liposomal Glutathione claims to support the body’s natural detox processes and optimize cellular health. You may use it by taking one serving (around 4ml) directly under your tongue or by mixing it in cold water, juice, or any preferred beverage.

   As per the official site, each 4 ml serving of Rho Nutrition Liposomal Glutathione gives 500 mg of CELLgsh® glutathione. CELLgsh® is e wrapped in tiny fat bubbles called liposomes. These bubbles could help glutathione pass through your stomach without breaking down, which might help enhance its absorption.

   CELLgsh glutathione may support white blood cell synthesis, which might help combat infections and keep you from getting sick. Glutathione may also help your body produce more collagen, which could help keep your skin firm and smooth.

   The makers state that Rho Nutrition Liposomal Glutathione is non-GMO, keto-friendly, and gluten-free. It is also produced in facilities that meet GMP and NSF standards. These certifications may help indicate clean and potentially safe formulation.

   However, Rho Nutrition Liposomal Glutathione may have a strong sulfur-like smell and taste, which is due to the presence of sulfur-rich cysteine in glutathione. The smell and taste might be unpleasant, especially if you are sensitive to strong flavors or smells.

   Pros

   • Uses CELLgsh® liposomal glutathione for better absorption.
   • It may help maintain skin firmness and smoothness.
   • It may help boost white blood cell production to support immunity.
   • It offers a non-GMO and gluten-friendly formula.
   • Made in GMP and NSF-certified facilities.
   • Comes with a 60-day refund policy on orders.

   Cons

   • It may have an unpleasant odor due to sulfur content.
   • Needs refrigeration after opening to maintain freshness.
   • The liquid form may be inconvenient for some users.

3. Doctor’s Best Glutathione + Milk Thistle

   

   Doctor’s Best Glutathione + Milk Thistle claims to support liver health and lower oxidative stress. Each serving (2 capsules) comprises 500 mg of Setria® glutathione, 250 mg of milk thistle seed extract (standardized to 80% silymarin), and 55 mcg of selenium as L-selenomethionine.

   Setria® is a premium glutathione form, which could help raise glutathione levels in the blood. Such effects may boost immunity and protect cells from oxidative damage. Milk thistle contains the silymarin compound, which may stimulate the liver to produce more glutathione.

   Doctor’s Best Glutathione + Milk Thistle also includes selenium, which may support the body’s natural detoxification processes, energy levels, and cellular health. However, selenium may also trigger potential side effects like nausea, hair loss, or fatigue.

   The Doctor’s Best Glutathione + Milk Thistle is also vegan, soy-free, gluten-free, and non-GMO. Such composition could make it potentially compatible with people with dietary restrictions.

   Pros

   • Combines glutathione and milk thistle to support liver health.
   • It provides antioxidants that may support cellular health.
   • Offers 60 capsules in a single bottle, lasting a month’s supply.
   • It might help boost energy levels and vitality.
   • Made using non-GMO and vegan-friendly ingredients.
   • The capsule form is easy to take, as it does not need measuring or mixing.

   Cons

   • It requires consistent use to observe noticeable effects.
   • The 500mg dose of glutathione might be excessive for some users.
   • It may not be suitable for people on blood thinners or liver medications.

4. GlutaDose Glutathione Wellness

   

   The makers state that GlutaDose Glutathione Wellness may help support the immune system and elevate energy levels. It could also support muscle recovery by lowering oxidative stress, which may help you recover faster after exercise.

   GlutaDose Glutathione Wellness contains glutathione, zinc, and acerola (vitamin C). Glutathione is a potent antioxidant that may support detoxification. Zinc could strengthen your immune system, and acerola provides vitamin C, which may support both immunity and skin health.

   As per the official site, GlutaDose Glutathione Wellness utilizes a Blow-Fill-Seal (BFS) technology, which may ensure the product is filled and sealed using a sterile, automated process.

   Each vial of GlutaDose Glutathione Wellness comes pre-measured, so you may easily take the right dose. You should take one vial every morning on an empty stomach. Pour the GlutaDose liquid under your tongue and hold it there for 10–15 seconds before swallowing.

   According to the official site, GlutaDose Glutathione Wellness is made in an FDA-compliant and GMP-certified facility in the USA. However, the vial packaging could be inconvenient, especially if you prefer a different delivery method or want a bulk supply.

   Pros

   • Pre-measured doses could be convenient for daily use.
   • It uses Blow-Fill-Seal (BFS) technology to maintain integrity and sterility.
   • It could help support energy, muscle recovery, and skin health.
   • Liquid delivery may be easier to absorb than pills.
   • Does not contain yeast, soy, or dairy.
   • It offers a 30-day refund policy on all orders.

   Cons

   • The convenience of vials might come at a higher cost.
   • You may experience side effects like nausea, bloating, or stomach pain.
   • The liquid form may have an unpleasant taste or texture.

5. Life Extension Glutathione, Cysteine & C

   

   According to the official site, each capsule of Life Extension Glutathione, Cysteine & C features 50mg of L-glutathione (as Setria®), 500mg of vitamin C, and 200mg of L-cysteine hydrochloride. They might help stimulate your body’s natural glutathione production and support antioxidant defense.

   Vitamin C might help strengthen your immune system, making it easier for your body to defend against illnesses. L-cysteine may help increase the levels of glutathione in your body, which might improve liver function and aid detoxification. Glutathione may help reduce oxidative stress, which might support better cellular health.

   Though Life Extension Glutathione, Cysteine & C is generally safe, there is a potential of experiencing side effects. These may include nausea, stomach cramps, bloating, diarrhea, or mild dizziness.

   Pros

   • Pairs glutathione, cysteine, and vitamin C for antioxidant effects.
   • You just need to take one capsule each day.
   • It may help boost energy levels and support liver health.
   • Contains non-GMO and gluten-free ingredients.
   • Vegetarian capsules may be suitable for people on plant-based diets.
   • Offers a 365-day refund policy on orders.

   Cons

   • It might not show immediate effects, requiring long-term use.
   • High sulfur content may cause a mild odor in the capsules.

6. NOW Foods Glutathione

   

   As per the makers, each capsule of NOW Foods Glutathione provides 500mg of glutathione, 50mg of alpha lipoic acid, and 100mg of milk thistle extract. It is available in containers of 30, 60, or 120 capsules, allowing you to choose the pack size that best suits your needs.

   The ingredients in NOW Foods Glutathione may help lower free radicals in your body. Alpha lipoic acid and milk thistle extract have antioxidant properties. These ingredients may help boost your immune system, support liver health, and improve skin tone.

   NOW Foods Glutathione claims to meet different dietary needs. It is kosher, vegan, dairy-free, soy-free, and non-GMO. Such composition could make NOW Foods Glutathione a good fit for people with dietary restrictions or sensitivities.

   Pros

   • Available in multiple capsule counts, offering flexibility in purchasing.
   • Contains 500 mg of glutathione per capsule.
   • It may reduce free radical damage and oxidative stress.
   • Free from allergens like gluten, dairy, soy, eggs, and nuts.
   • The small capsule size may be convenient to swallow.

   Cons

   • Contains rice flour, which may be problematic for those with rice allergies.
   • Alpha lipoic acid may interact with diabetes medications.

7. Quicksilver Scientific Glutathione

   

   According to the official site, Quicksilver Scientific Glutathione provides 100mg of Opitac® glutathione and 75mg of phosphatidylcholine in one ml (2 pumps). Opitac glutathione is a bioavailable form of glutathione that provides antioxidant benefits.

   Quicksilver Scientific Glutathione uses a special liposomal delivery method, which may improve how well your body absorbs and uses glutathione. It may help reduce inflammation, improve energy production, promote skin health, and support liver function.

   You may consume Quicksilver Scientific Glutathione by taking two pumps and holding the liquid in your mouth for 30-90 seconds before swallowing. It comes in cacao mint and lemon mint flavors and requires refrigeration after first use.

   The makers state that Quicksilver Scientific Glutathione is sugar-free, vegan, non-GMO, and soy-free. It is also made in a cGMP-certified facility to ensure its quality. However, you may experience side effects like cramping, bloating, and breathing difficulties, especially if you have asthma.

   Pros

   • Utilizes advanced liposomal delivery for enhanced absorption.
   • Available in Lemon Mint and Cacao Mint flavors.
   • Offers a convenient liquid form for easy dosing.
   • Does not contain soy, gluten, GMOs, or sugar.
   • Manufactured in-house, ensuring rigorous quality control.
   • It may support energy levels and immunity.

   Cons

   • Requires refrigeration upon receipt and use within 30 days.
   • Limited availability in some regions.

8. THORNE Glutathione-SR

   

   As per the official site, each capsule of THORNE Glutathione-SR contains 175mg of reduced glutathione. It also includes calcium laurate, hydroxypropyl methylcellulose, leucine, and magnesium citrate. These ingredients may help maintain the capsule’s structure.

   THORNE Glutathione-SR claims to support different aspects of your health. It could help protect your liver, brain, heart, lungs, and eyes by lowering oxidative stress and inflammation, which may otherwise damage these organs. It might also help your body recover faster after physical activity.

   As per the makers, THORNE Glutathione-SR is NSF Certified for Sport®, meaning it has passed testing to confirm that it contains only the listed ingredients. It also means that THORNE Glutathione-SR does not contain any banned substances in its formulation.

   Pros

   • Sustained-release formula may ensure steady glutathione levels.
   • Provides antioxidant support for the brain, liver, heart, lungs, and eyes.
   • NSF Certified for Sport®, ensuring product purity and safety.
   • Contains 175 mg of reduced glutathione per capsule.
   • It may support cognitive health during aging.
   • Comes with a 60-day refund policy on orders.

   Cons

   • Limited information on long-term use and safety.
   • It lacks flavored or alternative forms.
   • Not explicitly vegan-certified.

Are Glutathione Supplements Safe?

Glutathione supplements are typically safe when taken in the right amounts, which range from 500–1000mg a day for adults. However, their safety may depend on the dosage, type of glutathione supplement, and overall health.

The body may not absorb regular glutathione effectively, so some people may prefer liposomal glutathione or N-acetylcysteine (NAC) to boost their levels. Short-term use appears safe, but the long-term effects of glutathione are not fully known.

Prolonged use of glutathione might suppress your body’s natural glutathione production or lower zinc levels. There is also a potential chance of experiencing side effects like bloating, cramps, or skin rashes, but these are rare.

Potential Side Effects Of Glutathione Supplements

1. Uneven Skin Lightening

   Glutathione supplements might lighten your skin by reducing melanin, the pigment responsible for skin color. It may happen because glutathione could block the enzyme that produces melanin. However, it might not be even. Some areas of your skin could become lighter than others, creating an uneven tone. The effect may be more noticeable in people with darker skin.

2. Breathing Problems

   If you have asthma or other lung conditions, glutathione supplements could make breathing harder. When taken in inhaled form, glutathione might increase airway irritation, which may trigger coughing, wheezing, or shortness of breath.

   Some people without asthma might also feel mild chest tightness, which may happen as glutathione could affect mucus production in the lungs. If you notice breathing issues after taking a glutathione supplement, stop using it and talk to a doctor.

3. Decreased Zinc Levels

   Glutathione might lower your zinc levels over time, which occurs because glutathione binds to metals, including zinc, and removes them from the body. Since zinc is important for immune function, wound healing, and hormone balance, low zinc levels may cause problems.

   If your zinc drops too much, you might feel weak, get sick more often, or notice slow wound healing. There is also a potential chance of experiencing signs of zinc deficiency, such as brittle nails or hair thinning.

4. Digestive Discomfort And Bloating

   Glutathione supplements may cause bloating, cramps, or an upset stomach. These side effects might occur as your body processes glutathione through the liver and intestines, which might affect digestion.

   If your stomach is sensitive, you may feel gastrointestinal discomfort after taking glutathione supplements. You might also experience nausea or diarrhea, especially if your body struggles to absorb glutathione effectively.

5. Reduced Effectiveness of Some Medications

   Glutathione might interact with some medications, making them ineffective. If you take drugs for chemotherapy, blood pressure, or immune conditions, glutathione may change how they work. Such interactions may occur as glutathione affects liver enzymes that break down medications.

   Taking glutathione supplements may also impact the effectiveness of some antibiotics, pain relievers, or diabetes drugs.

How To Choose The Best Glutathione Supplement?

1. Type of Glutathione

   When choosing a glutathione supplement, you may want to consider the type that offers the most benefits. L-glutathione is the most basic glutathione form, but it might not absorb well in the gut, which could make it less effective.

   Reduced glutathione (GSH) is a more stable version that may be easier for your body to use. However, its absorption could still be limited when taken as a regular supplement.

   For better absorption, you might go for liposomal glutathione, which is protected by fat molecules. The liposomes could help your body absorb more glutathione and make it more effective. Another strong option is S-acetyl glutathione, which may be even more bioavailable.

2. Purity And Quality

   Checking for purity and quality is vital for selecting a glutathione supplement. You should go for a brand that undergoes third-party testing. The testing status may help verify that the supplement contains the right amount of glutathione and is free from harmful substances.

   A reliable brand might provide a certificate of analysis (COA) from an independent lab, which may give you more confidence in the product’s quality. You should also avoid glutathione supplements with unnecessary fillers, artificial colors, or preservatives.

   Some brands may add binders, magnesium stearate, or titanium dioxide, which do not provide any health benefits. If you have allergies or dietary restrictions, look for glutathione supplements that are non-GMO, gluten-free, and free from common allergens.

3. Check for Sulfur-Based Precursors

   Sulfur-based precursors may help your body produce and maintain glutathione more effectively. Methylsulfonylmethane (MSM) could support sulfur metabolism, which is important for keeping glutathione active.

   N-acetylcysteine (NAC) is a well-researched ingredient that may increase cysteine levels. Cysteine is a vital amino acid your body needs to make glutathione. Some supplements also contain alpha lipoic acid (ALA), which might help regenerate glutathione levels.

   However, you might experience mild side effects like bloating or headaches from these ingredients. Some people may also have trouble processing sulfur. If you notice discomfort, a reduced glutathione supplement without sulfur-based precursors could be a better choice.

4. Look for Enteric-Coated or Delayed-Release Capsules

   Glutathione is sensitive to stomach acid, which might break it down before your body can absorb it. It could make the glutathione supplement less effective, especially if it comes in a regular capsule or tablet.

   Enteric-coated and delayed-release capsules have a special coating that protects the glutathione. The coating may allow the glutathione supplement to pass safely through your stomach. It dissolves later in digestion so that the glutathione reaches your small intestine, where your body may absorb it better.

   Some high-quality brands include this feature, so checking for terms like “enteric-coated” or “delayed-release” on the label is important. Better absorption might lead to more noticeable benefits over time.

5. Check Consumer Feedback

   When choosing a glutathione supplement, you might want to check consumer reviews on trusted websites. These could include Amazon, the brand’s official website, Trustpilot, or Reddit. Reviews on these sites may help you understand how well a product works.

   Look for user reviews that mention clear benefits like brighter skin, more energy, or better detox effects. Be careful with user reviews that have aggressive claims or seem too perfect, as they might not be real.

Frequently Asked Questions

1. Can Glutathione Supplements Lighten Skin?
   Using glutathione supplements may help reduce melanin production, leading to a lighter skin tone. However, results might vary, and long-term safety for skin lightening is still debated. It is mainly used as an antioxidant rather than a skin-lightening treatment.
2. Is There A Difference Between Reduced And Oxidized Glutathione?
   Reduced glutathione (GSH) is an active glutathione form that works as an antioxidant in the body. Oxidized glutathione (GSSG) is the used form that needs to be converted back to GSH. Most supplements contain the reduced form for better effectiveness.
3. Are There Any Foods That Naturally Boost Glutathione Levels?
   Consuming sulfur-rich foods like garlic, onions, and cruciferous vegetables (broccoli, kale, and cabbage) may help boost glutathione production. Other foods like avocados, asparagus, and whey protein might also support higher glutathione levels.

Conclusion

Using glutathione supplements might help support liver health, boost your immunity, and promote skin health. You might also take them for their antioxidant benefits, which could help reduce oxidative stress and inflammation.

However, before opting for a glutathione supplement, you should consider factors like its form, dosage per serving, added ingredients, pricing, and quality certifications. Observing these factors might help you make an informed purchase decision.

Besides supplementation, you should try some simple lifestyle changes to raise glutathione levels naturally. Consuming sulfur-rich foods like cruciferous vegetables, onions, or garlic might help. Engaging in stress-relieving activities and limiting alcohol intake may also support natural glutathione production.