Contents
- What Are Vitamin K Supplements?
- 10 Best Vitamin K Supplements
- Side Effects of Vitamin K Supplement
- How Did We Evaluate The Best Vitamin K Supplements?
- Frequently Asked Questions
- Conclusion
Vitamin K supplements may help support multiple essential functions in the body. They could help support stronger bones, minimize calcium buildup in arteries to support cardiovascular health or support normal blood clotting.
Not all vitamin K supplements are created equal. Some may include MK-7, a form of vitamin K2 that stays in your body longer and increases bioavailability. Others might pair vitamin K2 with vitamin D3, which may help your bones absorb calcium more efficiently. A few vitamin K supplements may also include added magnesium to support cardiovascular health.
In this article, we provide a carefully curated list of the 10 best vitamin K supplements to help you make an informed purchase decision. The article also discusses the potential limitations of vitamin K supplements and lists the factors on which we ranked the best vitamin K supplements.
What Are Vitamin K Supplements?
Vitamin K supplements aim to deliver one or more forms of vitamin K, a fat-soluble nutrient that supports blood clotting, bone strength, and heart health. These supplements often contain vitamin K1 (phylloquinone), vitamin K2 (such as MK-4/MK-7), or both.
Vitamin K supplementation may be particularly helpful in cases of dietary vitamin K deficiencies, where you are unable to maintain adequate vitamin K levels through diet.
Taking vitamin K supplements could improve bone density, as the vitamin may help increase the body’s ability to absorb calcium and vitamin D. Supplements with K2 could play a more active role in bone metabolism and cardiovascular health by directing calcium to bones and removing its buildup in the arteries.
Vitamin K1 may help your liver to produce clotting factors, which are proteins that help stop bleeding in the injured area. Among K2 types, MK-7 may be especially effective, as it stays in the bloodstream longer and may support long-term bone and heart health better than K1 or MK-4.
Vitamin K supplementation may also be helpful if you take antibiotics (long-term) or medications that reduce vitamin K levels, such as bile acid sequestrants.
10 Best Vitamin K Supplements
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Igennus – Triple Vitamin K Complex
Igennus’ Triple Vitamin K Complex is specially formulated to support bone strength and cardiovascular function. It combines three bioactive forms of vitamin K, including K1, K2 MK-4, and K2 MK-7. These bioactive vitamin K forms may positively influence your body’s calcium regulation and natural blood clotting mechanisms.
According to its official site, one Triple Vitamin K Complex capsule delivers a 2700 mcg dose of vitamin K, including 1500 mcg of all-trans vitamin K1, 1000 mcg of all-trans K2 MK-4, and 200 mcg of all-trans K2 MK-7. The “all-trans” forms are the natural, biologically active isomers that your body can recognize and use effectively, which may contribute to better effectiveness.
The makers state that Triple Vitamin K Complex by Igennus contains hypoallergenic ingredients and is free from unnecessary additives like magnesium stearate or silicon dioxide. The supplement is also made to GMP standards in the UK and has a vegan-friendly composition.
Pros
- Pairs vitamin K1, MK-4, and MK-7 for full-spectrum support.
- May support bone mineralization and cardiovascular strength.
- Provides a three-month supply of vitamin K per bottle.
- Is free from GMOs, artificial flavors, and unnecessary fillers.
Cons
- May negatively interact with blood-thinning medications.
- Might trigger side effects like diarrhea, nausea, and stomach upset.
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Metagenics – Vitamin D3 5000 + K
Metagenics Vitamin D3 5000 + K aims to support strong bones, cardiovascular health, and a resilient immune system. As per its official site, one softgel provides 20 mcg of vitamin K1, 90 mcg of menaquinone (as MK-7), and 125 mcg (5000 IU) of vitamin D (cholecalciferol). These nutrients may support calcium absorption and utilization, helping direct calcium to your bones while reducing its buildup in soft tissues like arteries.
Formulated for faster absorption, Metagenics Vitamin D3 5000 + K uses a base of olive oil and medium-chain triglyceride (MCT) oil and includes d-alpha tocopherol as an antioxidant to preserve potency. The inclusion of vitamin K1, menaquinone (MK-7), and vitamin D may further help support skeletal strength and cardiovascular flexibility.
Pros
- Includes vitamin D to support healthy immune function.
- May support heart health and vascular function.
- Softgel format may be easy to swallow and gentle on the stomach.
Cons
- May elevate blood calcium levels, triggering nausea and fatigue.
- The softgels may stick together, causing inconvenience in consumption.
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Carlson Vitamin K2, MK-7
Vitamin K2, MK-7 by Carlson may support bone density, cardiovascular health, and calcium metabolism. It is available in two serving sizes of bottles with 90 softgels and 180 softgels, and the 90-count bottle costs $21.50 as part of a one-time purchase.
According to the official site, one softgel delivers 45 mcg of vitamin K2 as MK-7, derived from MenaQ7®. It is the only clinically studied form of MK-7 that supports both bone mineralization and vascular flexibility.
The Carlson Vitamin K2 MK-7 formula may support the activation of essential vitamin K-dependent proteins such as osteocalcin and Matrix Gla Protein (MGP). The process may help guide calcium to the bones where it’s needed while minimizing calcium deposition in the arteries.
Pros
- Contains no artificial preservatives, colors, or additives.
- Encapsulated in a softgel matrix to protect MK-7 from degradation.
- Undergoes third-party testing to verify potency and label accuracy.
Cons
- Might cause dizziness or lightheadedness in some users.
- Could trigger anxiety or an increased heart rate.
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Bronson Basics – Vitamin K2 MK-7
Bronson Basics’ Vitamin K2 MK-7 delivers a highly bioavailable form of vitamin K2, which may support stronger bones and cardiovascular health. As per its official site, one tablet provides 100 mcg of vitamin K2 (as menaquinone-7), which may help maintain normal bone density and arterial elasticity. It could help stabilize calcium levels in the body, which might support long-term skeletal and heart health.
As per the makers, Bronson Basics Vitamin K2 MK-7 comes in serving sizes of 120 tablets and 360 tablets per bottle, ensuring a consistent supply of vitamin K. The brand also offers free standard shipping on US orders worth $34.99 or above.
Pros
- May help support healthy calcium metabolism in the body.
- Made in GMP-certified labs under strict quality control standards.
- Offers a one-year refund policy on unused items.
Cons
- May deplete magnesium levels if used long-term.
- Does not contain vitamin D3 to support calcium metabolism further.
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Life Extension – Super K
Life Extension’s Super K aims to support the body’s natural calcium balance, which is vital for supporting bone density and healthy arteries. The formulation combines three variants of vitamin K, including menaquinone-4 (MK-4), vitamin K1, and menaquinone-7 (MK-7), which provide broad-spectrum support for arterial and bone health.
The MK-4 and MK-7 forms of vitamin K2 included in Super K are highly bioavailable and effective at activating proteins that may help add calcium to the bone matrix and minimize calcification in the arteries.
According to the official site, one softgel of Life Extension Super K delivers 2000 mcg of vitamin K, which includes 1000 mcg of menaquinone-4 (MK-4) and 180 mcg of menaquinone-7 (MK-7) in the form of MenaQ7®. The formula also comprises 10 mg of vitamin C as ascorbyl palmitate, which acts as an antioxidant.
The Life Extension Super K formula is non-GMO and gluten-free. It also contains other ingredients like extra virgin olive oil, gelatin, glycerin, beeswax, purified water, carob color, and maltodextrin. For optimal absorption, the makers suggest taking one softgel daily with food.
Pros
- May support cardiovascular health and minimize calcium buildup in the arteries.
- Opting for a subscription saves an extra 10% on the retail price.
- Provides a high-dose combination of vitamins K1 and K2 for robust support.
Cons
- Variability in results and effectiveness.
- Not suitable for vegans as it has bovine gelatin and palm glycerin.
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Thorne – Vitamin K
Thorne Vitamin K pairs vitamin K1 with two effective forms of vitamin K2 called menaquinone-4 and menaquinone-7. The formulation aims to support essential bodily functions, such as blood clotting, bone strength, and arterial flexibility.
According to its official site, one Thorne Vitamin K capsule delivers 1 mg of vitamin K1, 5 mg of vitamin K2 (as MK-4), and 90 mcg of vitamin K2 (as MK-7). Thorne claims that its Vitamin K formulation contains a high concentration of MK-4 alongside MK-7 in the form of MenaQ7®.
The makers state that Thorne Vitamin K is gluten-free, soy-free, and dairy-free, and is said to be free from artificial flavors or colors. One bottle of Thorne Vitamin K provides 60 capsules and is available at a one-time purchase price of $29.
Pros
- Pair three essential forms of vitamin K for comprehensive support.
- May support healthy bone mineralization.
- NSF Certified for Sport®, ensuring the formula remains free from banned substances.
- Offers a subscription service for regular, hassle-free delivery.
Cons
- Not suitable for use during pregnancy or nursing.
- The large capsule size may be hard to swallow for some users.
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Healthy Origins – Vitamin K2 as MK-7
Healthy Origins Vitamin K2 delivers vitamin K in a bioactive and long-lasting form called menaquinone-7 (MK-7). The MK-7 form has a superior absorption and extended half-life in the body, especially when compared to vitamin K1.
According to the official site, one softgel provides 100 mcg of vitamin K2 (as MK-7), which is sourced from natto. The Healthy Origins Vitamin K2 as MK-7 formula may help support bone density, promote cardiovascular health, and aid healthy calcium metabolism.
One jar of Healthy Origins Vitamin K2 as MK-7 provides 60 softgels and also comes with a serving size of 180 softgels per bottle. Opting for a subscription to Healthy Origins may save an extra 15% on the retail price.
Pros
- Could support arterial flexibility and health by minimizing arterial calcification.
- May also support improved energy and focus with consistent use.
- Comes in a small, easy-to-swallow pill form, making daily intake convenient.
Cons
- Potential for allergic reactions or sensitivities to ingredients.
- May require consistent use over months to observe noticeable results.
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Nature Made – Vitamin K2
According to the official site, one softgel from the Nature Made Vitamin K2 supplement offers 100 mcg of vitamin K2 in menaquinone-7 form. The formulation could help support a healthy circulatory system and help maintain strong bones.
The inclusion of menaquinone-7 in Nature Made Vitamin K2 may help activate matrix Gla-protein and osteocalcin. The process may provide calcium to bones and reduce its buildup in the arteries, which may contribute to cardiovascular health.
As per the makers, the United States Pharmacopeia (USP) organization has verified Nature Made Vitamin K2 100 mcg, assuring purity, potency, and quality. The formulation is also free from synthetic dyes, artificial flavors, and gluten.
Pros
- May support healthy bone density and integrity.
- Offers transparency in ingredient labeling and sourcing.
- It could be compatible with the dietary needs of people with gluten sensitivities.
Cons
- Has a comparatively higher price than similar formulations from competitor brands.
- Not suitable for people with soy allergies or sensitivity.
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Vital Nutrients – Vitamin K2-7
Vitamin K2-7 by Vital Nutrients provides 180 mcg of vitamin K2 in the highly bioavailable menaquinone-7 form. As a fat-soluble nutrient, vitamin K2 may support bone integrity and cardiovascular function by promoting healthy calcium distribution throughout the body.
The Vital Nutrients Vitamin K2-7 formula may support bone mineralization and structural strength. It could also help stabilize calcium levels in blood vessels, which may provide with arterial flexibility and lower the risk of calcification.
Besides its effects on bones and arteries, Vital Nutrients Vitamin K2-7 may contribute to supporting healthy lipid levels and glucose metabolism. One bottle of Vital Nutrients Vitamin K2-7 provides 60 capsules and is available at a one-time purchase price of $31.90.
Pros
- May help support healthy cholesterol and lipid levels.
- Could help compensate for the lack of vitamin K2-7 in the diet.
- Might contribute to healthy glucose metabolism to stabilize blood sugar levels.
Cons
- Might trigger allergic reactions, such as rashes, itching, or swelling.
- Overconsumption may lead to headaches and bone/muscle pain.
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Micro Ingredients – Vitamin K2 MK-7
Micro Ingredients Vitamin K2 MK-7 provides 200 mcg of vitamin K2 in the biologically active MK-7 form per softgel. The formulation may help stabilize calcium metabolism, a process that is essential to support bone strength, heart health, and arterial flexibility.
To enhance absorption, the softgels from Micro Ingredients Vitamin K2 MK-7 are infused with coconut oil. Pairing MK-7 with a quality fat source (like coconut oil) may ensure efficient uptake in the digestive system and minimize nutrient waste, allowing the body to utilize vitamin K2 more efficiently.
According to the official site, one resealable pouch of Micro Ingredients Vitamin K2 MK-7 contains 300 softgels, providing a generous 10-month supply when taken once daily. One pouch is available for $22.95 as part of a one-time purchase.
Pros
- Utilizes a bioavailable and stable form of vitamin K2 (MK-7) to ensure better absorption.
- May help support bone density and healthy joint function.
- At $22.95 for a 10-month supply, it offers a cost-effective purchase option.
Cons
- May give off an unpleasant smell or odor.
- Lacks transparency about ingredient sourcing and manufacturing quality.
Side Effects of Vitamin K Supplement
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Sweating
Excessive sweating may be an unpleasant side effect of vitamin K supplementation, especially when they are overconsumed. Supplements with vitamins K1 (phylloquinone) and K2 (menaquinone variants like MK-4 and MK-7) may overstimulate the autonomic nervous system. Such effects may activate your sweat glands more than usual, leading to bouts of excessive sweating that feel out of place or hard to control.
In some cases, excessive sweating may be a response to how your body is adjusting internally. Vitamin K may help stabilize calcium levels in your blood vessels. If the balance shifts too quickly, it may trigger your sympathetic nervous system, which may induce stress responses in the form of excessive sweating.
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Dizziness
Vitamin K supplements may lead to dizziness in some cases, especially when taken in high doses or without medical supervision. Vitamin K supports coagulation pathways through the activation of clotting factors II, VII, IX, and X, as well as proteins C and S. Its interaction with these systems may trigger changes in blood pressure or cerebral blood flow, contributing to feelings of lightheadedness or dizziness.
Dizziness from vitamin K supplements may appear suddenly and trigger lightheadedness, balance issues, or a spinning sensation. It may also come with other symptoms like blurred vision, nausea, or fatigue, making daily tasks difficult or unsafe. Vitamin K supplementation may interfere with how your blood vessels regulate pressure and flow. The reaction may sometimes contribute to a dizzy feeling.
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Rapid Heartbeat
A rapid heartbeat, also called tachycardia, is a potential side effect that may occur with vitamin K supplementation. Supplements with vitamin K forms like phylloquinone (K1) and menaquinone (K2) may influence your autonomic nervous system or cardiovascular function, potentially triggering palpitations or elevated heart rate.
Another possible cause is how vitamin K supplements work with calcium in your body. Vitamin K-dependent proteins, such as matrix Gla-protein (MGP) and osteocalcin, help control calcium deposition in the body. Abrupt shifts in calcium handling, particularly if you have an electrolyte imbalance, might contribute to irregular heart rhythms, including tachycardia.
How Did We Evaluate The Best Vitamin K Supplements?
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Brand Credibility
In evaluating the best vitamin K supplements, we emphasized consumer trust, prioritizing brands that have an established presence on platforms like Trustpilot and the Better Business Bureau (BBB). These platforms offer valuable insight into how well a brand serves its customers, handles complaints, and maintains transparency.
Brands such as Life Extension and Bronson Vitamins have a strong presence on Trustpilot. Life Extension has earned a 4.4 out of 5 rating based on over 350+ reviews, showing strong customer approval among Trustpilot reviewers. Bronson Vitamins maintains a 3.5 out of 5 Trustpilot rating from more than 2,500+ reviews, highlighting both its popularity and dependable service.
We also considered BBB ratings to complement the Trustpilot data, especially for brands with limited online reviews. Carlson Labs has received A+ ratings from the BBB, a sign of reliable business practices and responsible customer service. Similarly, Healthy Origins has also received an A+ rating on the BBB platform. However, these brands do not maintain a strong presence on Trustpilot.
On the other hand, Metagenics had both a Trustpilot rating, which is 2.2 out of 5, based on 10 reviews, and a “B” rating on the BBB platform, suggesting a mixed reputation that may warrant caution depending on customer expectations.
Thorne had an unclaimed profile on Trustpilot but received a “C+” rating on the BBB website, indicating inconsistencies in consumer satisfaction.
Other brands like Micro Ingredients, Igennus, and Vital Nutrients lacked reviews and presence on both Trustpilot and BBB platforms. Although the three brands are recognized in niche or professional circles, the lack of transparent customer feedback made it harder to verify their reliability from a broader consumer perspective.
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Pricing and Value
When evaluating the best Vitamin K supplements, pricing per serving was a primary factor in our evaluation. While some brands offer premium ingredients or added nutrients, we focused on how well the cost aligned with the quantity delivered by each vitamin K supplement.
Micro Ingredients’ Vitamin K2 MK-7 offered value by providing one jar (300 softgels) for $22.95. Bronson Basics’ Vitamin K2 MK-7 100 MCG provides one jar (120 tablets) for $9.97, making it one of the most cost-effective vitamin K supplements.
Other economical choices included Healthy Origins Vitamin K2 as MK-7 at $12.99 for 60 softgels and Carlson’s Vitamin K2 at $21.50 for 90 softgels ($0.24 per serving). These formulations may be suitable for consumers seeking simple vitamin K supplements.
Life Extension’s Super K provides one bottle (90 softgels) for $22.50, and Igennus’ Triple Vitamin K Complex offers one bottle (90 capsules) for $23.95. These formulations pair multiple forms of Vitamin K, including K1, MK-4, and MK-7, providing broader health support at a reasonable price. Metagenics Vitamin D3 5000 + K offers one jar (with 60 softgels) for $28.25, which offers 5000 IU of vitamin D3.
At the premium end, Thorne Vitamin K offers one bottle (60 capsules) for $29, and Vital Nutrients Vitamin K2-7 is priced at $31.90 for one bottle (60 capsules). These products cater to users who prioritize clean, pharmaceutical-grade ingredients. Nature Made Vitamin K2 100 mcg is the most expensive among all vitamin K2 supplements, providing 30 softgels for $20.99.
Frequently Asked Questions
- Who Might Require Vitamin K Supplements?
People with diets deficient in vitamin K, absorption problems, or those on medications (such as antibiotics and bile acid sequestrants) may require vitamin K supplementation. Those at an increased risk for vitamin K deficiency include older adults and people with liver-related conditions. - Can I Pair Vitamin K Supplements With Vitamin D?
Yes, you may consume vitamin K supplements alongside vitamin D. Vitamin D may help your body absorb calcium, while vitamin K could direct calcium to your bones and minimize arterial calcification to support bone and heart health. - Are Vitamin K Supplements Safe to Take With Blood Thinners?
No. Vitamin K supplements may negatively interact with blood-thinning medications like warfarin by reducing their effectiveness and altering blood clotting. Therefore, it is advisable to refrain from taking vitamin K formulations alongside blood thinners. - Is It Better To Take Vitamin K1 or K2 Supplements?
Both vitamin K1 and K2 supplements may support blood clotting, but they have different roles and absorption rates in the body. Vitamin K2 is generally better absorbed, stays in the bloodstream longer, and may offer added benefits for bone and heart health than vitamin K1. The best choice may depend on your specific health needs and goals.
Conclusion
Vitamin K supplements may help support bone health, cardiovascular function, and calcium regulation. Research highlights the role of vitamin K in activating proteins like osteocalcin and matrix Gla-protein, which help direct calcium into bones and support vascular function.
The 10 vitamin K supplements featured in the article may offer a variety of options, which include formulations with either vitamin K1, MK-4, and MK-7, or a combination of all for broad-spectrum support. Many supplements also include added ingredients like vitamin D and calcium to support bone health further and promote a resilient immune system.
However, vitamin K supplements may trigger potential side effects, including excessive sweating, dizziness, and rapid heartbeat. These adverse effects are often attributed to shifts in calcium levels or nervous system responses as a result of vitamin K supplementation. Vitamin K formulations may also negatively interact with blood thinners like warfarin or antibiotics, which may further lead to adverse side effects.
Rachel has been a freelance medical writer for more than 18 years. She graduated from the University of Tennessee at Knoxville in 2005 and is currently practicing as a Certified Registered Nurse Anesthetist at a Level I trauma center.
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