Published On By Rachel Nall

L-citrulline is a natural amino acid present in watermelon and produced by your body. It helps increase L-arginine and nitric oxide levels, which may improve blood flow and circulation.

Taking L-citrulline supplements could enhance your workouts by boosting blood flow to your muscles and delivering more oxygen and nutrients. This could also help improve your stamina, reduce fatigue, and speed up muscle recovery.

While small amounts of L-citrulline can be obtained from food, supplements may provide you with a more concentrated dose, allowing you to maximize the benefits for fitness, heart health, and energy levels.

However, L-citrulline can lower blood pressure, so combining it with antihypertensive medications may lead to dizziness or fatigue, especially at high doses.

In this article, we have listed down the 8 best L-citrulline supplements, with details on their benefits, drawbacks, and how they work. We’ve also included some tips to help you choose the right formula for your specific health needs.

What Is L-citrulline Supplement?

L-citrulline is a non-essential amino acid that your body naturally produces. When taken as a supplement, L-citrulline may help increase levels of L-arginine, which might boost nitric oxide production. Nitric oxide widens your blood vessels, improving blood flow and delivering more oxygen and nutrients throughout your body.

Taking L-citrulline supplements could enhance blood flow to your muscles during exercise, which may help deliver more oxygen and nutrients. This might lead to improved workout performance, increased stamina, reduced muscle fatigue, and faster recovery. However, they should be used carefully, especially for people on blood pressure medication, as L-citrulline could lower blood pressure.

8 Best L-citrulline Supplements

  1. BulkSupplements L-citrulline Powder

    BulkSupplements L-citrulline Powder

    Bulk Supplements L-citrulline powder claims to support the production of nitric oxide, which may improve blood flow and vascular health. It could help reduce muscle fatigue during exercise, enhance endurance, and support faster recovery post-workout by promoting better circulation.

    According to the official website, each serving (1 tsp) of Bulk Supplements L-citrulline powder gives you 3 grams of L-citrulline, which may support a better muscle pump that lasts longer. It could also help you recover faster by reducing muscle soreness after exercise.

    Bulk Supplements L-citrulline powder might help remove lactic acid and boost ATP production, which is needed for muscle energy. It is said to be third-party tested and cGMP-certified with no added sugar, making it a safe and clean option.

    Pros & Cons

    Pros

    • cGMP-certified and free from allergens and sugar.
    • Enhances endurance by reducing muscle recovery time.
    • Helps reduce post-workout soreness and fatigue.
    • Comes with flexible dosage options.
    • Third-party tested for purity and safety.
    • It could support improved blood flow and muscle pump.

    Cons

    • You may find the taste of the powder unappealing.
    • Requires careful measurement for proper dosing.
    • It may cause mild stomach discomfort.
    • No added flavor, may not mix well in certain liquids.
    • Only available in powder form, not in capsules.
  2. PureBulk L-citrulline DL-Malate Powder

    PureBulk L-citrulline DL-Malate Powder

    As per the manufacturer, PureBulk L-citrulline DL-Malate Powder combines L-citrulline and malic acid in a 2:1 ratio to boost your exercise performance.

    The L-citrulline in this formula might help improve blood flow and increase nitric oxide production, while malic acid could help remove waste from your muscles and reduce muscle fatigue.

    The makers state that each PureBulk L-citrulline DL-Malate Powder serving gives you 2000 mg of L-citrulline and 1000 mg of malic acid, which may help you push through intense workouts.

    PureBulk L-citrulline DL-Malate Powder is said to be third-party tested in the USA, which ensures that the formula is free from harmful contaminants. It may also help alleviate muscle soreness and expedite recovery times, allowing you to train more effectively.

    Pros & Cons

    Pros

    • It could increase nitric oxide production, improving blood flow.
    • The malic acid could help remove ammonia waste.
    • It offers a subscription option, making consistent supply easier.
    • It is tested for purity, potency, and identity.

    Cons

    • It doesn’t have added flavors, which might not be enjoyable for you.
    • You’ll need to measure the powder accurately for proper dosing.
    • It might not be as convenient as capsules.
  3. Double Wood Supplements L-citrulline

    Double Wood Supplements L-citrulline

    As per the makers, Double Wood Supplements L-citrulline might help improve your athletic performance, endurance, and cardiovascular health. It could also boost nitric oxide production, which can improve blood flow and circulation, giving you a pump when lifting weights.

    L-citrulline from Double Wood Supplements promises to support better aerobic exercise and muscular endurance, making it a suitable addition to your fitness routine. It might also help with the ammonia recycling process and the metabolism of NO, which can improve your overall performance.

    According to the official website, Double Wood provides Certificates of Analysis (COA) and third-party testing results to ensure you’re getting a potent and pure product.

    Pros & Cons

    Pros

    • It could help make your workouts more effective.
    • It might support muscle endurance and aerobic exercise performance.
    • Soy-free, gluten-free, and contains non-GMO ingredients.
    • It is third-party tested with Certificates of Analysis for quality assurance.
    • It offers a 30-day refund policy.
    • It provides clear ingredient labeling.

    Cons

    • You might need a higher dose if you’re doing very intense workouts.
    • It’s not always available in stores.
    • It may be more expensive than other generic L-citrulline products.
  4. Zazzee L-citrulline Capsules

    Zazzee L-citrulline Capsules

    Zazzee L-citrulline Capsules claims to provide 1800 mg of L-citrulline Malate per serving(3 capsules), a potent blend of L-citrulline and malic acid that might support muscle recovery, stamina, and performance.

    As per the makers, Zazzee L-citrulline Capsules could help reduce fatigue and soreness by aiding the removal of ammonia, a byproduct of intense exercise. It may also support protein metabolism, promoting muscle growth and recovery.

    Zazzee L-citrulline Capsules might help enhance blood flow, improving nutrient delivery to muscles, which can boost your endurance and energy during workouts. It could also help detoxify your liver.

    The official website highlights that Zazzee L-citrulline Capsules are manufactured in the USA in an FDA-certified facility, which ensures strict quality control standards with no fillers or additives.

    Pros & Cons

    Pros

    • It is 100% vegan and natural, with no fillers or additives.
    • You get 1800 mg of L-citrulline Malate per serving.
    • It could enhance recovery and reduce soreness.
    • It may boost your stamina during workouts.

    Cons

    • It is only available through the official website.
    • Results may take longer to appear.
    • It’s high doses of citrulline might not be suitable for you.
  5. Nutricost L-citrulline Malate Powder

    Nutricost L-citrulline Malate Powder

    As per the manufacturer, Nutricost L-citrulline Malate Powder may boost your workout performance and help with recovery. It is said to have a 2:1 ratio of L-citrulline to Malate, giving you 3 grams per serving.

    Nutricost L-citrulline Malate Powder might help improve blood flow by increasing nitric oxide, which can boost your energy, endurance, and muscle pumps during exercise. It could also help reduce muscle fatigue and speed up recovery so that you can get back to your workouts faster.

    The markers state that Nutricost L-citrulline Malate Powder may support better oxygen delivery to your muscles, which can improve your performance and decrease soreness after exercise. It also comes in different sizes (300g, 600g, or 1.2kg).

    Nutricost L-citrulline Malate Powder is said to be gluten-free, non-GMO, and third-party tested to ensure quality and potency. It’s made in an FDA-registered and GMP-compliant facility, ensuring the formula is safe for consumption.

    Pros & Cons

    Pros

    • You get 3 grams of L-citrulline Malate per serving.
    • The 2:1 L-citrulline to Malate ratio may improve your blood flow.
    • Available in multiple sizes (300g, 600g, or 1.2kg), giving you flexibility in quantity.
    • Manufactured in a GMP-compliant, FDA-registered facility, ensuring high-quality standards
    • It’s gluten-free, non-GMO, and third-party tested for quality

    Cons

    • With no flavor options, it may taste bland to you.
    • It does not come in pre-measured dosage.
    • You might find it harder to mix with liquids or shakes.
  6. Healthy Origins L-citrulline Powder

    Healthy Origins L-citrulline Powder

    Healthy Origins L-citrulline Powder claims to help improve your workout performance by supporting healthy nitric oxide levels in your body.

    It is said to contain the fermented form of L-citrulline (KQ), which could help boost your endurance and circulation, making high-intensity workouts feel easier and helping you recover faster.

    According to the official website, Healthy Origins L-citrulline Powder is made in a cGMP facility, following strict quality standards. It is also free from wheat, gluten, soy, milk, egg, fish, shellfish, peanuts, and tree nuts, so it’s safe for you if you have food sensitivities.

    Pros & Cons

    Pros

    • It could support your athletic performance by boosting nitric oxide.
    • It’s gluten-free, soy-free, dairy-free, and free from other common allergens.
    • Checked for purity and potency through third-party testing.
    • It might improve muscle oxygenation and reduce soreness.
    • It provides a 30-day refund policy.
    • Manufactured in a cGMP facility, ensuring strict production standards.
    • Manufactured without using genetically modified ingredients or harmful chemicals.

    Cons

    • The benefits may take some time to show.
    • Texture could be groundy even after mixing properly.
    • It might not be suitable for you if you have allergies to fermented ingredients.
    • Only available in a single-size
  7. NOW Foods Supplements L-citrulline Capsules

    NOW Foods Supplements L-citrulline Capsules

    As per the official website, NOW Foods L-citrulline Capsules could help strengthen your immune system, making it easier for you to stay healthy and recover faster.

    Each NOW Foods L-citrulline capsule gives you 750 mg of L-citrulline, which might help your body process protein more effectively. It may also support muscle growth, recovery, and overall performance.

    NOW Foods L-citrulline Capsules could support your body’s natural healing process while boosting your immune defenses. They are said to be free from common allergens like gluten, soy, milk, eggs, and nuts.

    Pros & Cons

    Pros

    • Provides 750 mg of L-citrulline per capsule for effective protein metabolism and immune support.
    • Supports muscle recovery, protein metabolism, and a healthy immune system.
    • Vegan, kosher, halal, and non-GMO for diverse dietary preferences.
    • Manufactured in a GMP-certified facility in the USA for quality assurance.
    • Easy to include in your daily routine.

    Cons

    • It may require multiple capsules for higher doses.
    • Natural color variation may occur.
    • Capsules may not be suitable for you if you prefer powder forms.
  8. Horbäach L Citrulline Capsules

    Horbäach L Citrulline Capsules

    Horbäach L-citrulline Capsules claims to provide 2,400 mg of pure, free-form L-citrulline per serving, which may help boost your workouts. It could help enhance your muscle strength and endurance, which may support your workout session.

    As per the makers, Horbäach L-citrulline capsules might support quicker recovery by reducing muscle soreness and fatigue so you can stay consistent with your fitness routine. It could also aid in overall circulation, which can support your cardiovascular health.

    Horbäach L-citrulline Capsules may help maintain better energy levels throughout your training sessions by reducing muscle stiffness. They are said to be non-GMO and free from gluten, wheat, yeast, lactose, soy, artificial flavors, and preservatives.

    Pros & Cons

    Pros

    • You get a high dose of 2,400 mg of L-citrulline per serving for potency.
    • It may boost your muscle strength, endurance, and recovery.
    • You could experience better blood flow and nitric oxide production for workouts.
    • It’s free from gluten, wheat, lactose, soy, and artificial preservatives.
    • It is a non-GMO formula with no artificial additives.
    • The capsule form allows for easy consumption

    Cons

    • The capsules might be hard to swallow.
    • You might find it less convenient than powdered options.
    • Results may take time to notice.
    • It doesn’t include extra ingredients for added workout benefits.

Are L-citrulline Supplements Safe?

L-citrulline products are generally safe for you when taken as directed. Since L-citrulline is a natural amino acid, your body is familiar with it and could adequately process it. Recommended daily doses typically range from 3 to 10 grams. For exercise performance, 6 to 8 grams of L-citrulline malate may be effective, while doses of 3 to 9 grams per day have been studied for cardiovascular health. L-citrulline is generally well-tolerated, with no significant side effects reported at doses up to 15 grams daily. However, if you take high doses, you might experience mild adverse effects like stomach discomfort, bloating, or diarrhea, especially if you take it on an empty stomach.

How Does L-citrulline Supplement Work?

L-citrulline works by increasing the levels of L-arginine in your body. When you take L-citrulline supplements, your body absorbs it and converts it into L-arginine in your kidneys. This L-arginine is then used to produce nitric oxide, which may help widen blood vessels and improve blood flow. Taking L-citrulline products might also promote better nutrient and oxygen exchange in muscles during intense physical activity by boosting nitric oxide levels. This can potentially reduce the accumulation of lactic acid and ammonia, which can contribute to muscle soreness. However, remember that these results can vary, and you should consult with a doctor if you have any health concerns.

Potential Side Effects Of L-citrulline Supplements

  1. Nausea

    Taking L-citrulline may cause nausea, especially if you take higher doses. This can happen due to an increase in nitric oxide that can irritate your gastrointestinal system, leading to an upset stomach. You might also experience symptoms such as queasiness, bloating, a heavy feeling in your stomach, or the urge to vomit. This effect is more likely to occur if you take L-citrulline on an empty stomach or too quickly after a meal.

  2. Stomach Discomfort

    If you take too much L-citrulline, it can lead to stomach pain due to its effect on digestion. The nitric oxide boost causes blood flow to the gut, which can disturb the natural digestion process. You might experience symptoms like bloating, cramping, a sensation of fullness, or gas. This discomfort might become more noticeable if you’re prone to digestive issues or have a sensitive stomach.

  3. Diarrhea

    L-citrulline products can sometimes cause diarrhea, particularly if you take larger doses than the maker’s recommended dosage. It can draw extra water into your intestines, speeding up bowel movements. As a result, you might experience loose stools, urgency to use the bathroom, frequent trips, or dehydration, which could lead to symptoms like dry mouth, dizziness, and fatigue.

  4. Allergic Reactions

    Though rare, L-citrulline can trigger allergic reactions, which might happen when your immune system mistakenly identifies L-citrulline as harmful. You might experience symptoms like skin rashes, itching, hives, swelling (especially in the face, lips, or throat), or trouble breathing.

  5. Dizziness Or Lightheadedness

    L-citrulline’s vasodilation effects could reduce blood flow to the brain, causing dizziness or lightheadedness, particularly if you’re dehydrated. You might feel unsteady on your feet, experience vertigo, or have trouble focusing. These symptoms may be worse if you stand up quickly or are in a hot environment, as your body may already be struggling to maintain proper blood pressure.

  6. Heartburn

    L-citrulline can sometimes cause heartburn as it can relax your muscle that stops stomach acid from moving up into your esophagus. As a result, you may feel a burning sensation in your chest, a sour taste in your mouth, or discomfort after eating. If you already have acid reflux or GERD, you might notice this side effect more.

  7. Interaction With Certain Medications

    Taking L-citrulline products along with medications that affect blood pressure or erectile dysfunction treatments intensifies their effects. If you’re on these medications, taking L-citrulline could cause your blood pressure levels to drop too low, leading to symptoms like dizziness, fainting, nausea, or weakness.

How To Choose The Best L-citrulline Supplements?

  1. Dosage

    Considering the dosage is essential when choosing the best L-citrulline supplement. Many brands provide L-citrulline dosage of 3 to 4 grams per day, which you may consider depending on your goals. Some products mix L-citrulline with other ingredients, so check the label to see how much L-citrulline is in the product to ensure you’re getting enough. You might also find products that include “L-citrulline malate,” which combines L-citrulline with malic acid. This combination may help with endurance and reduce fatigue during workouts. Just make sure the label clearly states how much L-citrulline is in the product, especially if it’s mixed with other ingredients.

  2. Formulation

    L-citrulline products come in different forms, like powders and capsules. Powder form could be a convenient option and let you adjust the dosage easily. However, powders can taste sour or unpleasant, and you’ll need to measure them carefully to get the right dose.

    Capsules and tablets could be easy to take and pre-measured, making them for daily use. However, they could be more expensive per serving, and you may not be able to adjust the dose as easily. If you have trouble swallowing pills, the size of the capsules might also be an issue.

    Some L-citrulline products include extra ingredients like electrolytes, vitamins, or other amino acids to support performance and recovery. Make sure to check the label to see if these added ingredients match your health goals and don’t contain anything you’re allergic to.

  3. Brand Reputation

    It’s crucial to consider the brand’s reputation when selecting an L-citrulline product. A trusted brand is more likely to provide high-quality formulas that are both safe and effective. Look for brands with positive customer reviews, as these can indicate that their product is likely to work well and be safe for use.

    Brands with a good reputation often have a history of transparency, meaning they are clear about where their ingredients come from and how their products are made. Also, check for certifications like Good Manufacturing Practices or third-party testing, as reputable brands often invest in quality control measures.

  4. Third-Party Testing

    Third-party testing involves independent laboratories verifying the product’s purity, potency, and safety, ensuring that it contains the stated amount of active ingredients and is free from contaminants such as metals, pesticides, or harmful microbes. Choosing L-citrulline supplements that have been third-party tested offers safety, especially if you have strict health requirements. Look for certifications from organizations such as Informed Choice, NSF International, or USP (United States Pharmacopeia). These seals indicate that the product meets high standards for quality and transparency. However, if a product lacks clear information about third-party testing, you may consider alternatives with verified certifications.

  5. Customer Reviews And Testimonials

    Customer reviews and feedback may help you choose the best L-citrulline supplement. You can find out about benefits like better endurance or faster recovery, as well as any possible downsides, such as taste or side effects, by reading what others have experienced.

    Instead of focusing on just one review, look for common points across multiple reviews to get a clearer idea of how the product works. Pay attention to reviews with goals similar to yours, whether you’re an athlete, fitness enthusiast, or someone looking to improve heart health.

    Considering reviews available on reliable sites like Trustpilot or health blogs might give you a more honest view as compared to the manufacturer’s website. However, stay careful of reviews that seem too positive or negative without enough detail, as they can be misleading.

Frequently Asked Questions

  1. Can L-citrulline Supplements Help With Weight Loss?
    L-citrulline supplements may aid weight loss by activating the PKA-LKB1-AMPK-HSL signaling pathway in adipose tissue, which enhances fat breakdown (lipolysis) and boosts energy metabolism.
  2. Is L-citrulline Supplement Suitable For Vegans?
    L-citrulline is suitable for vegans, as it is a non-essential amino acid typically derived from plant sources. However, you should verify product labels to ensure no animal-derived additives are included in specific formulations.
  3. Can I Stack L-citrulline Supplements With Other Products?
    You can stack L-citrulline with creatine supplements, as it could enhance strength and muscle growth by improving blood flow. Pairing it with beta-alanine might help reduce muscle fatigue and boost endurance.
  4. Are There Natural Food Sources of L-citrulline?
    Natural food sources of L-citrulline include watermelon, cucumbers, and pumpkins. These foods can contribute to your dietary intake, although supplementation may be necessary for enhancing exercise performance and recovery.

Conclusion

L-citrulline supplements can help improve your exercise performance, boost blood flow, speed up recovery, and increase stamina. However, if you have low blood pressure or are taking medication for high blood pressure, you should avoid L-citrulline products, as they may lower your blood pressure too much.

In this article, we’ve listed the 8 best L-citrulline supplements, all chosen for their quality and effectiveness. We’ve also covered everything you need to know about L-citrulline formulas.

To get the most out of your L-citrulline products, you may consider natural methods like staying hydrated, eating foods like watermelon or beets that boost nitric oxide, and engaging in regular physical activity to enhance blood flow and support muscle health further.

Disclaimer
  • The information in this guide is for informational purposes only and should not be considered medical advice.
  • It is not recommended to disregard/delay seeking professional medical advice or treatment because of what you read or accessed through this guide.
  • The results may vary from individual to individual.
  • Consult your doctor for any underlying medical conditions or if you are on any prescribed medicines before trying any product.

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