Best 10 Holy Basil Supplements in 2025

Holy basil supplements contain a concentrated form of holy basil extract, which has adaptogenic effects. These supplements are often standardized for compounds like eugenol or ursolic acid, which may help support immunity, lower stress levels, and promote metabolism.

It is important to note that some holy basil formulations use leaf-only extracts, which tend to be richer in polyphenols, while others include whole-plant extracts, offering a broader range of phytochemicals. Added ingredients like ashwagandha, rhodiola, or bacopa may also impact the efficacy of holy basil supplements.

This blog post highlights the 10 best holy basil supplements based on formulation integrity, active ingredient concentration, customer reviews, and brand reliability. You’ll also find insights on the potential side effects or interactions to consider before choosing a holy basil supplement.

10 Best Holy Basil Supplements

1. Zazzee Naturals Holy Basil

   

   According to the official site, Zazzee Naturals Holy Basil features a concentrated 10:1 holy basil (Ocimum tenuiflorum) extract, with each capsule delivering the herbal equivalent of 6000mg of holy basil leaves. It may help support calmness, lower anxiety levels, and support a healthy immune response.

   Zazzee Naturals Holy Basil comprises ursolic acid, an antioxidant and anti-inflammatory compound. Urosolic acid may help lower stress by decreasing cortisol levels and supporting hypothalamic-pituitary-adrenal (HPA) axis balance. It may also activate the AMP-activated protein kinase (AMPK) pathway, which could improve metabolic function and support healthy blood sugar levels.

   As per the manufacturer, Zazzee Naturals Organic Holy Basil is formulated without the use of synthetic pesticides, herbicides, or GMOs. It also excludes harmful ingredients like artificial fillers, binders, and chemical excipients to support compatibility with multiple dietary restrictions.
   

   Pros

   • Has a USDA Organic certified formula, indicating strong manufacturing and quality standards.
   • May support emotional resilience and lower stress levels.
   • Offers a lifetime money-back guarantee on purchases.
   • Provides antioxidant effects that may lower inflammation and oxidative stress.

   Cons

   • Has potential blood-thinning effects, which may increase the risk of bruising or bleeding.
   • May trigger gastrointestinal discomfort, such as nausea, diarrhea, or stomach upset.

2. Rejuvica Health Active Holy Basil Extract

   

   Rejuvica Health’s Active Holy Basil Extract comes in a 4fl oz (118ml) bottle. It contains liquidified Holy basil extract, which may provide faster absorption and be particularly helpful if you prefer liquid formats over capsules or tablets.

   As per the official site, Active Holy Basil Extract from Rejuvica Health is formulated using a liquid glycerin extraction method, which involves using vegetable glycerin as the primary solvent instead of alcohol. Such extraction may help preserve the integrity of sensitive phytochemicals in Holy basil extract by avoiding high heat or harsh solvents. Active Holy Basil Extract’s alcohol-free preparation might also be gentler on your digestive system.

   Rejuvica Health’s Active Holy Basil Extract may help support metabolism, lower fatigue, and support healthy blood sugar levels. For use, the makers suggest squeezing 1–2 full droppers (approximately 1/4 teaspoon) of Active Holy Basil Extract formula into your mouth directly or mix in a glass of water.
   

   Pros

   • Might help improve sleep quality and minimize the risk of insomnia.
   • Offers free shipping on all U.S. orders.
   • Liquid delivery format may offer faster absorption of Holy basil extract over capsules or powders.
   • Could support immunity by stimulating the production of white blood cells.

   Cons

   • May cause fatigue or drowsiness during initial use.
   • Variations in results and effectiveness.

3. Oregon’s Wild Harvest – Organic Holy Basil Capsules

   

   As per the official site, Organic Holy Basil Capsules by Oregon’s Wild Harvest feature 60 vegan capsules per jar, with one serving (two capsules) providing 800mg of organic Holy basil leaf extract. The capsules are made from organic pullulan, which is derived from fermented tapioca starch.

   Holy basil leaf extract contains eugenol and other phytochemicals that may support serotonin and dopamine neurotransmitter activity. Such effects could help elevate your mood and maintain emotional resilience. It might also reduce oxidative stress and neuroinflammation, both of which are linked to disrupted sleep patterns.

   The makers state that Oregon’s Wild Harvest Organic Holy Basil Capsules exclude herbicides, synthetic additives, and heavy metals. For use, the makers suggest consuming 1–2 capsules daily.
   

   Pros

   • Is free from artificial colors, irradiated herbs, GMOs, and fillers.
   • The formulation is verified non-GMO by SGS, an independent third-party lab.
   • Might support healthy blood sugar levels and insulin response.

   Cons

   • Label does not standardize ursolic acid or total triterpenes, so the transparency of active compound levels remains unclear.
   • Capsule format may digest more slowly than liquid-based Holy basil supplements.

4. MaryRuth’s Holy Basil Leaf Liquid Drops

   

   MaryRuth’s Holy Basil Leaf Liquid Drops may help support your body’s resilience to occasional physical, emotional, or environmental stress. As per the official site, it comes in a 30-ml (1 fl oz) bottle, with one serving (0.5ml) featuring 590mg of Holy basil leaf extract.

   Holy basil leaf extract contains bioactive compounds like eugenol, rosmarinic acid, and ursolic acid. These compounds may help lower cortisol (stress hormone) levels and promote a calmer mental state. MaryRuth’s Holy Basil Leaf Liquid Drops may also support digestive health, as Holy basil leaf extract may protect your gastric lining by increasing mucus secretion and reducing stomach acidity. Such effects may support digestion and minimize concerns like bloating.

   MaryRuth’s Holy Basil formula also possesses antioxidant effects. It might aid your body’s natural detoxification pathways by supporting detox enzymes and helping neutralize free radicals, which are often linked to oxidative stress. For use, the makers suggest consuming up to 15 drops (0.5ml) one to three times a day, either directly by mouth or mixed with water.
   

   Pros

   • The formulation is free from common allergens, such as soy, nuts, dairy, sugar, or alcohol.
   • Opting for a subscription may provide an extra 10% discount on purchases.
   • May help promote alertness and potentially boost focus.
   • Clean Label Project (CLP) certified, which may indicate formulation purity and safety.

   Cons

   • The ursolic acid content may trigger fluctuations in the menstrual cycle.
   • May aggravate hypothyroidism by lowering thyroxine levels.

5. Gaia Herbs Holy Basil Supplement

   

   Gaia Herbs’ Holy Basil supplement may help support your body’s innate response to everyday stressors, both physical and mental.

   As per the official site, one capsule provides 363mg of a proprietary extract blend, which includes organic holy basil leaf and a supercritical CO₂ extract of the same herb. The dual-extraction method may improve the absorption of both water- and fat-soluble compounds in Holy basil extract. Gaia Herbs’ Holy Basil supplement also features 8.5mg of eugenols, a compound with antioxidant and anti-inflammatory effects.

   Holy basil leaf extract may help support immunity by influencing cytokine activity and decreasing pro-inflammatory markers like IL-6 and TNF-α. It may also stimulate natural killer (NK) cells and enhance phagocytic function, supporting both innate and adaptive immunity.

   As per the official site, Gaia Herbs Holy Basil supplement holds a Fair for Life Fair Trade Certification. The certification may indicate that Gaia Herbs follows ethical sourcing practices, including fair wages and transparency throughout the supply chain.
   

   Pros

   • Offers a vegan and gluten-free formula, increasing compatibility with diverse dietary needs.
   • May support respiratory health and cognitive function.
   • Provides a sustained phyto‑capsule delivery format for efficient absorption and easy swallowing.

   Cons

   • Is comparatively more expensive than Holy basil supplements from other brands.
   • The eugenol content may increase the potential risk of experiencing a rapid heartbeat.

6. NutriONN – Holy Basil Leaf Extract

   

   As per the official site, NutriONN Holy Basil Leaf formulation contains 500mg of Holy basil leaf extract per capsule, standardized to 2.5% ursolic acid. It may help lower cortisol levels, which might support focus, mood stability, and energy balance.

   Holy basil leaf extract contains compounds like rosmarinic acid and ursolic acid, which may help decrease inflammation in blood vessels and boost endothelial function. These compounds may also help stabilize blood pressure levels by promoting vasodilation through nitric oxide pathways.

   NutriONN Holy Basil Leaf Extract formula may support bone health and blood clotting. Holy Basil leaf extract is naturally rich in vitamin K that may help activate osteocalcin. It is a protein needed for binding calcium to bones, which could support bone mineralization and strength.
   

   Pros

   • May offer antioxidant support via natural eugenol content.
   • Could help minimize symptoms of respiratory issues, such as colds and coughs.
   • Each bottle contains 120 capsules, providing an extended supply.
   • Made in FDA-inspected, GMP-compliant US facilities, indicating stringent quality standards.

   Cons

   • May trigger side effects like headaches or dizziness.
   • Offers a 14-day restrictive refund policy from the date of delivery.

7. Carlyle Nutritionals Liquid Holy Basil Extract

   

   As per the official site, Carlyle Nutritionals Liquid Holy Basil Extract comes in a 59ml (2 fl oz) bottle, with each serving providing 2ml of Holy Basil extract. It may help support your body’s stress response, immune function, and cardiovascular health.

   Compounds like eugenol and ursolic acid in Holy basil extract may help suppress cortisol secretion and lower oxidative stress in the brain. Such effects might promote a balanced mood and suppress feelings of anxiety.

   The makers state that Carlyle Nutritionals Liquid Holy Basil Extract offers a vegetarian formula, which does not contain artificial flavors or sweeteners. For use, the recommended dose is 1–2 ml of Carlyle Nutritionals Liquid Holy Basil Extract formula, diluted in a small amount of water to allow for flexible use.
   

   Pros

   • Could support heart health by helping lower LDL (bad) cholesterol levels.
   • Might help improve energy levels and endurance.
   • Excludes potential allergens like wheat, yeast, and lactose from its formulation.

   Cons

   • May amplify sedative effects if used alongside barbiturates or sleep medications.
   • Some users have experienced an unpleasant aftertaste after consumption.

8. Wild & Organic Holy Basil Tincture

   

   Holy Basil Tincture by Wild & Organic may support relaxation and help improve mood. According to the official site, one serving (0.7ml) features 600mg of organic holy basil leaf extract, providing around 168 servings per bottle. Wild & Organic claims that its Holy Basil Tincture has a 98% absorption rate, which may support prompt effects in stress relief and focus enhancement.

   The holy basil leaf extract may support emotional resilience alongside cardiovascular and metabolic health. It may do so by helping your body adapt to internal and environmental stressors. Organic vegetable glycerin is also added to Holy Basil Tincture as a solvent and carrier. It may also produce a mild energizing effect without spiking your blood sugar levels.

   Before use, the makers suggest shaking the bottle well and adding one full squeeze of the dropper bulb (around 0.7ml) into 2 oz. of water or juice. You may consume Wild & Organic’s Holy Basil Tincture twice daily.
   

   Pros

   • Uses purified water alongside glycerin to preserve bioactive compounds in the formula.
   • May easily mix in different liquids, including coffee, juice, or smoothies.
   • Could help improve VO2 max and lung capacity, thereby promoting endurance.

   Cons

   • Not safe for use in cases of autoimmune diseases, as it might overstimulate the immune system.
   • The liquid format may be inconvenient for some users, especially those who prefer tablets/capsules.

9. Herbal Secrets Holy Basil

   

   According to the official site, a two-capsule serving of Herbal Secrets’ Holy Basil formula contains 1000mg of Holy basil extract per serving, standardized to 2% ursolic acid.

   The manufacturer states that Herbal Secrets Holy Basil may help support emotional resilience, improve energy levels and endurance, and decrease oxidative stress. Herbal Secrets Holy Basil is also free from allergens, such as tree nuts, fish, eggs, soy, and preservatives.
   

   Pros

   • Could help support a sense of emotional calm and mental acuity.
   • The adaptogenic effects may help minimize frequent mood swings.
   • May support a healthy glucose metabolism.

   Cons

   • Does not maintain transparency on whether the brand accepts refunds or not.
   • May lack standardized dosing across batches.

10. Nature’s Way – Holy Basil Premium Extract

    

    As per the official site, Nature’s Way Holy Basil Premium Extract provides 450mg of Holy basil leaf extract per capsule, standardized to 2.5% ursolic acid (11.25 mg). Ursolic acid may help provide mild relaxation effects by decreasing cortisol levels and suppressing inflammatory pathways. The Nature’s Way Holy Basil Premium Extract also comes with a 45-day satisfaction guarantee on purchases from the date of purchase.
    

    Pros

    • Made in NSF-certified and ISO-compliant facilities, indicating adherence to quality manufacturing practices.
    • Offers free standard U.S. shipping on purchases worth $35 or more.
    • Might help minimize mental fatigue symptoms, such as forgetfulness and decreased motivation.

    Cons

    • The large capsule size could be difficult to swallow for some users.
    • Prolonged or excessive use may trigger allergic reactions, such as itchiness, rash, or breathing problems.

What Are Holy Basil Supplements?

Holy basil supplements are made from the leaves, stems, or extracts of the holy basil plant (Ocimum sanctum or Ocimum tenuiflorum). The active compounds in holy basil include eugenol, ursolic acid, rosmarinic acid, and different flavonoids and terpenes.

Such phytochemicals have anti-inflammatory and adaptogenic effects, which might help support physiological balance and improve stress resilience.

Some holy basil supplements use standardized extracts to ensure consistent levels of the bioactive compounds, such as 2% ursolic acid or 0.5% eugenol. The holy basil supplements are commonly available in capsule, softgel, powder, or liquid formats.

A randomized, double-blind, placebo-controlled trial investigated the impact of a standardized Ocimum tenuiflorum extract (Holixer™) on participants experiencing stress. The study found noticeable reductions in cortisol (stress hormone) levels and improvements in sleep quality over 8 weeks, compared to a placebo. Holy basil supplementation may also help decrease fatigue, promote healthy immune responses, reduce inflammation, and improve cytokine levels.

Side Effects Of Holy Basil Supplement

1. Decreased Blood Sugar Levels

   Holy Basil supplements may cause a potential drop in blood glucose levels, especially if you are taking them with medications like insulin, metformin, or glipizide. These supplements may stimulate your pancreas to release more insulin, thereby moving more sugar from your blood into your muscles for energy. If the blood sugar levels are already normal, these effects may cause them to drop too low.

   Decreased blood sugar levels from Holy basil supplementation may trigger hypoglycemia symptoms, such as dizziness, shaking, sweating, confusion, blurred vision, or irritability. It is safe to monitor your blood glucose levels when using Holy Basil supplements to avoid such negative occurrences.

2. Hormonal Fluctuations

   The concentrated nature of Holy Basil supplements may intensify their effects on your endocrine system. More notably, these supplements help lower cortisol (a stress hormone produced by your adrenal glands). Over-suppression of cortisol hormone might interfere with your body’s natural stress response, contributing to fatigue, mood instability, and reduced resilience to everyday stressors.

   Holy Basil supplementation may also impact thyroid function, as high-dose use may lower the levels of thyroxine (T4), a thyroid hormone. It may pose a potential risk if you have an underactive thyroid or are on thyroid medication, potentially causing symptoms like sluggish metabolism, weight gain, and cold sensitivity.

3. Gastrointestinal Discomfort

   You may experience digestive discomfort after taking Holy Basil supplements, especially if you’re using high doses or concentrated forms like tinctures or standardized extracts. Eugenol, methyl eugenol, and carvacrol present in Holy Basil may irritate the stomach and intestinal lining. Such effects may disrupt gastric balance, irritate mucosal surfaces, and increase gut sensitivity, which may cause digestive discomfort. Common symptoms of gastrointestinal discomfort include nausea, stomach cramps, bloating, acid reflux, and mild diarrhea.

How Did We Evaluate The Best Holy Basil Supplements?

1. Brand Credibility

   When evaluating the best holy basil supplements, we analyzed the ratings and presence of all the brands on third-party platforms like the Better Business Bureau (BBB) and Trustpilot, as these forums may offer insights into how well the brands handle customer complaints and engage with public feedback.

   Nature’s Way maintains an “A+” rating on the Better Business Bureau (BBB), which may indicate its strong customer service practices and responsiveness. However, Nature’s Way does not maintain an active page on Trustpilot. It is followed by Rejuvica Health, which is BBB accredited and holds an “A+” rating on the platform, although the brand lacks a presence on Trustpilot.

   Similarly, Oregon’s Wild Harvest holds an “A+” rating on BBB, although it has an unclaimed profile on Trustpilot. Meanwhile, Carlyle Nutritionals holds an “A-” rating on BBB, which is impacted by four complaints filed against the brand on BBB.

   On the other hand, Mary Ruth’s brand has a rating of about 3.3 out of 5 on Trustpilot based on 5+ reviews. Maru Ruth also holds an “F” rating on BBB due to unresolved consumer complaints.

   Wild & Organic also maintains an “F” rating on BBB, citing failure to respond to customer complaints, and shows no engagement on Trustpilot.

   Meanwhile, other brands like Zazzee Naturals, Gia Herbs, NutriONN, and Herbal Secrets either have unclaimed profiles on Trustpilot or have no presence on the BBB and Trustpilot platforms. The lack of active brand engagement could limit transparency and leave a gap in publicly verifiable customer experiences.

2. Refund Policy

   For evaluating the best Holy Basil supplements, we analyzed the flexibility and duration of their refund policies as a measure of brand transparency and customer support. Zazzee Naturals offers a Lifetime Money Back Guarantee on purchases, offering hassle-free refunds and an extensive window to evaluate the effectiveness of its products.

   Brands like Oregon’s Wild Harvest and Rejuvica Health both provide a 60-day return window. Oregon’s policy allows returns regardless of the condition of the returned items, while Rejuvica Health restricts returns to only unused and unopened items and does not refund shipping fees.

   Gaia Herbs and Nature’s Way each provide a 45-day return period. Gaia Herbs calculates the refund window from the shipment date and may request proof of purchase, with a refund processing time of around 7–10 business days. Nature’s Way counts the 45-day refund window from the date of purchase and excludes shipping charges from refunds. It also monitors for return abuse and may deny requests at its discretion.

   Brands like Mary Ruth’s, Carlyle Nutritionals, and Wild & Organic each offer a 30-day return window. However, Mary Ruth’s only provides exchanges or store credit, rather than direct refunds. Carlyle Nutritionals does offer refunds, but does not cover return shipping and reserves the right to modify the policy at any time. Wild & Organic requires items to be unused, in the original package, and a proof of purchase to qualify for a return.

   NutriONN’s refund policy allows returns within 14 days of delivery, and the refund items should be in original packaging accompanied by a Return Merchandise Authorization number. However, Herbal Secrets is the least transparent regarding refunds, as there are no details on whether the brand accepts refunds or not.

3. Value for Money

   When evaluating the Holy Basil supplements, we compared their pricing with the quantity provided, using cost per serving as the base. Wild & Organic Holy Basil Tincture is priced at $18.29 for one bottle (120 ml) that provides approximately 168 servings, which translates to a cost of around $0.11 per serving. It is followed by NutriONN Holy Basil Leaf Extract, which costs $19.95 for one jar with 120 capsules. One jar (120 capsules) of Herbal Secrets’ Holy Basil Supplement is priced at $19.99, offering a cost of around $0.17 per serving. These options may provide cost-effectiveness in relation to quantity.

   Rejuvica Health Active Holy Basil Extract offers a liquid formula, with a 118 ml bottle (containing up to 96 servings) priced at $18. It may translate to a cost of around $0.19 per serving. Meanwhile, Zazzee Naturals Organic Holy Basil provides one jar with 120 capsules for $23.97, equating to approximately $0.20 per capsule.

   Carlyle Nutritionals Liquid Holy Basil formula is available at $8.99 for one 59-ml jar with about 30 servings, costing around $0.30 per serving. MaryRuth’s Organic Holy Basil Leaf Liquid Drops comes in a 30 ml bottle for $19.95 and contains roughly 60 servings. On the other hand, Nature’s Way Holy Basil Premium Extract provides 60 vegan capsules for $23.49, which works out to roughly $0.39 per capsule.

   On the higher end, Oregon’s Wild Harvest Organic Holy Basil Capsules are priced at $27.95 for one jar with 60 capsules, translating to a cost of around $0.47 per capsule. However, Gaia Herbs Holy Basil Leaf supplement is the most expensive in terms of cost per serving, offering 60 liquid phyto-caps for $53.09, which amounts to around $0.88 per capsule.

Frequently Asked Questions

1. Are There Differences Between Leaf and Extract Forms of Holy Basil Supplements?
   Yes. Holy Basil Extracts contain more active compounds and offer stronger effects. Leaf supplements may be gentler and better tolerated by sensitive digestive systems.
2. Do Holy Basil Supplements Require Refrigeration?
   No, as such, Holy Basil supplements do not require refrigeration. Capsules and powders may remain stable at normal room temperatures if protected from heat and humidity.
3. Can Holy Basil Supplements Affect Menstrual Cycles?
   Maybe. Holy basil supplements might influence hormone levels, which could result in spotting, irregular periods, or menstrual changes in some people.
4. Do Holy Basil Supplements Have A Strong Taste or Smell?
   Yes, Holy basil supplements, particularly in tincture or powder forms, have a noticeable clove-like aroma and a sharp, slightly bitter aftertaste due to high eugenol and essential oil concentrations.

Conclusion

Holy Basil supplements may help you tackle everyday stress, support metabolic function, or promote immunity. Some Holy basil formulations are specifically curated to support antioxidant activity and help maintain glucose and lipid metabolism within normal ranges.

However, Holy Basil supplementation is not without potential limitations. Prolonged or overuse of Holy basil supplements may trigger side effects like nausea, dizziness, or gastrointestinal discomfort. Due to the impact of Holy basil supplements on endocrine function, overuse may also negatively impact hormone-related functions, such as blood sugar control, thyroid function, and even fertility.

Integrating some lifestyle changes may complement the adaptogenic and antioxidant benefits of Holy basil supplements. For example, getting at least 7–9 hours of uninterrupted sleep daily may help stabilize cortisol secretion and lower stress levels. Consuming anti-inflammatory foods like turmeric, fatty fish (such as salmon or sardines), leafy greens, chia seeds, and berries may further support immune and metabolic health.

Meanwhile, practicing stress-reducing techniques such as 10-minute daily breathing exercises, guided meditation, or gentle yoga stretches may enhance parasympathetic nervous system activity, potentially amplifying Holy Basil Supplement effects.