Published On By Rachel Nall

Saffron supplements claim to help support mood, energy, and digestion. It may help improve your mood by boosting serotonin hormone levels, which could help suppress feelings of sadness or stress.

Research suggests that saffron’s active compounds, such as crocin, crocetin, and safranal, might help minimize symptoms of depression, support cognitive function, and improve appetite control.

While saffron supplements hold promise, it’s important to use them responsibly. Using saffron supplements might contribute to potential side effects such as dizziness, nausea, or allergic reactions.

If you’re considering saffron supplements and want to find the best options for your needs, this guide to the top seven saffron supplements may help. The guide also discusses how saffron supplements work, their potential risks, and factors to consider before choosing them.

What Are Saffron Supplements?

Saffron is extracted from the dried stigma (part) of the Crocus sativus flower, with each flower producing just three stigmas. However, due to the high price point of saffron, many people turn to saffron supplements.

They typically come in capsule or extract form and may have mood-elevating effects. Saffron extract may also help minimize symptoms of stress, anxiety, and depression by increasing serotonin hormone levels in the brain.

Saffron supplements contain compounds called carotenoids. These carotenoids might help protect your cells from oxidative stress and inflammation, which might help lower the risk of chronic diseases.

While saffron supplements are generally considered safe, they may potentially trigger mild side effects. These may include headaches, dizziness, and digestive issues like nausea or stomach cramps.

7 Best Saffron Supplements

  1. PureMicronutrients Saffron Extract Supplement

    PureMicronutrients Saffron Extract Supplement

    Developed by Tessa Sanos, PureMicronutrients saffron extract features therapeutic doses of saffron. Each capsule delivers 88.5 mg of hand-harvested saffron extract from the Crocus sativus flower, with 60 servings provided in every bottle.

    Packed with antioxidants, saffron may help boost dopamine levels in the brain, which could improve memory, focus, and emotional balance. Saffron’s anti-inflammatory effects might also support digestion, boost metabolism, and suppress appetite.

    As per the makers, PureMicronutrients saffron extract intends to specifically help with issues such as low energy, mood swings, PMS, mild anxiety, or difficulty focusing. It claims to offer a natural means to tackle and minimize such challenges.

    PureMicronutrients saffron extract is made in the USA and undergoes regular third-party testing to ensure its purity and potency. It is also said to be free from common allergens like gluten, dairy, harmful fillers, and GMOs, indicating a high-quality and safe formulation.

    While PureMicronutrients Saffron extract has multiple benefits, it may not work the same for everyone. Some might find the cost higher than similar products, and personal experiences with PureMicronutrients Saffron extract could vary.

    Pros & Cons

    Pros

    • It features 88.5 mg of pure, hand-harvested saffron extract, ensuring premium quality and potency.
    • The saffron extract from PureMicronutrients may help boost dopamine levels, which could support improved mood, memory, and focus.
    • PureMicronutrients saffron extract is developed by a registered nutritionist Tessa Sanos, who offers a formulation backed by expertise and care.
    • Regular quality checks by third-party independent labs may help ensure purity, potency, and safety, giving you confidence in PureMicronutrients saffron extract.
    • The PureMicronutrients saffron extract formula does not contain allergens like gluten, GMOs, dairy, or harmful fillers, making it potentially safe for use.
    • PureMicronutrients saffron extract comes with a lifetime satisfaction guarantee, which may indicate their confidence in its effectiveness.

    Cons

    • You might experience a bad aftertaste, which might be off-putting and may deter consistent use.
    • People with bipolar disorder or blood pressure issues cannot use PureMicronutrients saffron extract.
    • Results might take time and consistent use to become noticeable.
  2. Youtheory Saffron Supplement

    Youtheory Saffron Supplement

    Youtheory saffron formulation claims to provide 28 mg of Affron®, a clinically studied saffron extract, along with 350 mg of Rhodiola root extract and 150 mg of ashwagandha leaf extract (Sensoril®). These ingredients are paired to provide you with a balanced approach to optimize mental and physical health. Affron® is a high-quality saffron extract, which is standardized for active compounds that may help improve mood, reduce stress, and support emotional balance.

    Rhodiola root extract could improve your body’s ability to handle stress and combat fatigue, promoting sustained energy and focus. Sensoril® ashwagandha might further help lower stress, encourage relaxation, and improve cognitive function, helping you stay calm and focused.

    Although Youtheory saffron formulation has many strengths, the saffron content per serving(2 capsules)  is lower than other saffron supplements, which might not meet the needs of those seeking a higher dosage.

    Pros & Cons

    Pros

    • Youtheory pairs Affron®, Rhodiola root extract, and Sensoril® ashwagandha for a comprehensive stress and mood support formula.
    • It claims a stimulant-free formulation, which could make it a potentially safe option for lowering stress and elevating mood.
    • The two capsules per day dosage could make it easy to include Youtheory saffron formula in your daily routine without any hassle.
    • Sensoril® ashwagandha in Youtheory may encourage relaxation without causing drowsiness, making it potentially safe for daytime use to reduce anxiety and stress.
    • Affron® saffron extract might help lift mood and decrease symptoms of mild depression, contributing to better emotional health.

    Cons

    • The lack of clarity regarding independent third-party testing may be concerning.
    • You might experience mild digestive discomfort or an upset stomach when taking the Youtheory saffron supplement.
  3. Mother Nutrient Saffron Extract Supplement

    Mother Nutrient Saffron Extract Supplement

    Mother Nutrient saffron extract comes with 240 vegetarian capsules in one bottle, giving you a 7-month supply. It means you don’t have to worry about frequent restocking, making it easy to include in your daily routine.

    According to the official site, each capsule of Mother Nutrient saffron extract provides 88.5 mg of saffron extract from the Mediterranean, giving you a potent dose of this beneficial spice. Saffron extract is known for boosting mood, but it may also offer other benefits.

    It might help with digestion and controlling your appetite, which could assist in your weight loss efforts. Saffron also has antioxidants that may help reduce stress in the body, potentially supporting heart health.

    As per the makers, Mother Nutrient saffron extract is made in the USA with ingredients from around the world. It’s produced in cGMP-certified labs that meet good manufacturing and quality control practices.

    The Mother Nutrient saffron extract formula claims to be free from heavy metals and harmful contaminants to ensure its safety. It does not contain allergens like GMOs, soy, gluten, and nuts.

    Pros & Cons

    Pros

    • With 240 capsules per bottle, Mother Nutrient saffron extract offers a 7-month supply. It may reduce the need for frequent purchases and ensure convenience.
    • Each capsule features 88.5 mg of saffron extract.
    • Saffron extract may help reduce feelings of anxiety and improve overall emotional balance.
    • The Mother Nutrient saffron extract formula is free from GMOs, soy, gluten, and nuts.
    • Mother Nutrient’s saffron extract is manufactured in the USA in cGMP-certified facilities.

    Cons

    • For those sensitive to saffron, the 88.5 mg per capsule might be too high and could trigger mild side effects, such as headaches or nausea.
    • It only contains saffron extract and does not include a mix of beneficial herbs and vitamins, which may indicate limited ingredient variety.
  4. Resciency Saffron Supplement

    Resciency Saffron Supplement

    Resciency Liposomal saffron extract is a formulation that uses liposomal delivery technology to maximize absorption. Liposomal delivery works by encasing the saffron and other ingredients in tiny lipid vesicles (particles), helping them transit through your digestive system more easily.

    Each 2ml serving of Resciency Liposomal saffron extract drops contains 88.5mg of saffron extract, along with 100mg of ashwagandha root extract and 50mg each of Rhodiola extract, turmeric extract, and magnesium. It also features nutrients like vitamins B12 and D3.

    Ashwagandha root extract has adaptogenic effects, which means that it could help lower stress levels and promote relaxation. Turmeric extract might help lower inflammation and support heart health, while Rhodiola extract might help boost energy levels.

    However, Resciency Liposomal saffron extract may trigger potential side effects. These may include drowsiness, bloating, diarrhea, irregular heart rhythms, stomach upset, etc.

    Resciency Liposomal saffron extract claims to be vegan, GMO-free, and gluten-free, and it’s made in the USA in a GMP-compliant facility. To use, simply shake the bottle, squeeze out 2ml of the liquid, and add it to water or juice.

    Pros & Cons

    Pros

    • Resciency uses liposomal technology to deliver saffron extract.
    • The formula includes added ingredients like ashwagandha, turmeric, magnesium, and vitamins B12 and D3. They could help support energy levels, mood, immunity, and metabolism.
    • Resciency products are produced in a GMP-compliant facility in the USA, which may indicate that strict standards of quality and safety are met.
    • Resciency Liposomal saffron extract is easy to take, as you just need to consume two drops daily.
    • Ingredients like ashwagandha and Rhodiola might help reduce stress and improve mood, offering a calming effect throughout the day.
    • The Resciency formula is vegan, gluten-free, dairy-free, and soy-free.

    Cons

    • Some users might not like the taste when they take Resciency Liposomal saffron formula directly under the tongue or mix it in water/juice.
    • The liquid form with liposomal delivery technology could be more expensive than standard saffron formulations.
    • You may experience mild stomach upset, bloating, or diarrhea, especially when consuming the Resciency formula on an empty stomach.
  5. Luma Nutrition Saffron Extract Supplement

    Luma Nutrition Saffron Extract Supplement

    Luma Nutrition saffron extract formulation provides 88.50mg of saffron extract in each capsule. Each bottle provides 60 capsules, giving you a 30-day supply. It is made in the USA in GMP-certified facilities that undergo third-party testing to ensure quality and potency.

    Saffron extract from Luma Nutrition claims to support your vision by protecting your eyes against damage from free radicals. It could also help improve your mood by increasing serotonin levels. Saffron may also aid in weight loss goals by reducing appetite, making it easier for you to stick to your diet.

    For optimal results, the makers recommend taking one capsule of Luma Nutrition Saffron Extract twice daily with water, ideally 20-30 minutes before meals.

    While Luma Nutrition Saffron Extract offers many benefits, you may experience side effects like headaches or stomach discomfort.

    Pros & Cons

    Pros

    • The antioxidants in Luma Nutrition saffron extract might help shield the eyes from oxidative damage, supporting vision health.
    • It could help suppress cravings and support weight loss efforts by making it easier to reduce portion sizes and adhere to a balanced diet.
    • It is made in GMP-certified facilities in the USA, ensuring high standards of quality, cleanliness, and safety throughout the production process.

    Cons

    • The calming effects of saffron might lead to drowsiness or tiredness.
    • You might experience adverse health interactions like dizziness, nausea, or dry mouth.
    • Saffron could interact with blood thinners or sedative drugs.
  6. ZuvaLabs Saffron Supplement

    ZuvaLabs Saffron Supplement

    ZuvaLabs saffron extract supplement contains 88.5mg of saffron extract in each capsule, which is standardized to 0.3% Safranal, a natural compound in saffron that may help improve your mood and promote calmness.

    Besides mood support, ZuvaLabs saffron extract could help protect your eyes from strain and support clear vision, especially if you spend excessive time in front of screens. It might also improve digestion by reducing bloating, cramping, and constipation, helping you feel more comfortable after meals.

    However, results with ZuvaLabs saffron extract may vary from person to person. Factors like diet, lifestyle, and overall health may affect how well it works. While some users may experience improvements in mood or digestion, others might not observe noticeable outcomes.

    ZuvaLabs saffron extract is made in a GMP-certified facility in the USA. It is also vegan, non-GMO, and free from wheat, eggs, nuts, or dairy.

    Pros & Cons

    Pros

    • ZuvaLabs saffron extract may elevate mood and support digestion.
    • The saffron extract from Zuva Labs might help reduce eye strain and maintain clear vision, especially for those who spend long hours in front of screens.
    • It may help reduce bloating, cramping, and constipation, promoting smoother digestion and minimizing discomforts after meals.
    • ZuvaLabs saffron extract is free from artificial additives like GMOs and does not contain allergens like nuts, eggs, wheat, dairy, and gluten.

    Cons

    • Saffron may interact with some medications, particularly those affecting blood pressure or blood sugar levels.
    • The effectiveness of Zuva Labs saffron extract may differ from person to person, with some users experiencing minimal or delayed results.
  7. Nutricost Saffron Extract Supplement

    Nutricost Saffron Extract Supplement

    Nutricost’s saffron extract supplement offers 88.5 mg of saffron extract per capsule and may potentially support your mood support and focus. One bottle of Nutricost saffron extract contains 240 capsules, which shall last eight months if taken as per the maker’s suggested dose of one capsule a day. Nutricost saffron extract claims to support your weight loss goals by suppressing appetite and minimizing cravings for unhealthy foods. It’s manufactured in a GMP-compliant facility, which means it may follow strict quality standards for safety and effectiveness.

    Pros & Cons

    Pros

    • Nutricost saffron extract offers an impressive 88.5mg dose of saffron extract per capsule.
    • With 240 vegetarian capsules in each bottle, you have an eight-month supply.
    • You only need to take one capsule a day.
    • Nutricost saffron extract offers a vegetarian, gluten-free, soy-free, and non-GMO formulation.
    • Nutricost saffron extract may help elevate mood, lower stress levels, and boost energy levels.

    Cons

    • Nutricost saffron extract could be comparatively more expensive than similar saffron supplements on the market.
    • You may experience mild side effects such as stomach upset, headaches, or dizziness, especially when starting Nutricost saffron extract use.

How Do Saffron Supplements Work?

Saffron supplements work by using the active compounds in the saffron flower, like safranal, crocin, and picrocrocin. These compounds may interact with important brain chemicals, such as serotonin, dopamine, and norepinephrine, which control mood.

The interaction of saffron compounds with these brain chemicals may potentially help minimize symptoms of depression and anxiety. Such an effect could help you feel more relaxed and emotionally stable.

Research highlights that saffron’s effects on mood may be as strong as those of some prescription antidepressants but with fewer side effects. It could make saffron supplementation more appealing if you’re looking for a safer substitute for traditional medications.

Saffron could also act as an appetite suppressant, which might help support your weight loss goals. It may work by helping suppress food cravings and emotional eating, potentially helping you stick to a healthy routine.

Some studies indicate that crocin in saffron could improve blood circulation to the retina, which is important for good vision. By protecting the retina from damage, saffron could also support the eye’s ability to repair itself, promoting better overall eye health.

However, the quality and purity of saffron supplements might vary, meaning some saffron products may not provide the same benefits as others. Saffron supplements are also not a quick fix and might take time to show noticeable results.

Potential Side Effects of Saffron Supplements

  1. Drowsiness

    Saffron supplements may have a calming effect, which could lead to drowsiness or fatigue. Crocin compound in saffron might contribute to feelings of relaxation, which could interfere with your daily activities or make you feel overly tired during the day. If you experience drowsiness, it’s best to take saffron supplements at night or when you don’t need to be active. Remain cautious about driving or operating heavy machinery after taking saffron if you feel unusually sleepy.

  2. Low Blood Pressure

    Saffron may lower blood pressure, which could be a concern if you already have low blood pressure or are taking medications for the same. It may have a mild blood pressure-lowering effect, which could make you feel lightheaded or dizzy, particularly when you stand.

  3. Dry Mouth

    Taking Saffron supplements may cause dry mouth due to how saffron interacts with the nervous system or affects the body’s natural hydration balance. A dry mouth may lead to discomfort and difficulty swallowing or speaking, which could be bothersome. If you experience dry mouth after using saffron formulations, staying hydrated might help. If the issue persists, it’s a good idea to consult a doctor to see if saffron is the cause.

  4. Allergic Reactions

    Saffron might cause allergy breakouts, leading to symptoms like hives, rash, itching, or swelling. If you are sensitive or allergic to plants in the iris family (like crocus), saffron could trigger an allergic response. In rare cases, an allergic reaction to saffron may cause you to experience discomfort or more severe symptoms, such as dizziness or breathing difficulties. If you observe any such signs of an allergic reaction after taking saffron, it’s important to stop using the formulation immediately.

How To Choose The Best Saffron Supplements?

  1. Purity of Saffron

    When choosing the best saffron formulations, purity is an essential factor to consider. Many saffron products on the market are mixed with fillers or synthetic saffron, which means you may not be getting the full benefits of the potent herb.

    Looking for saffron supplements that contain a high percentage of pure saffron extract may help ensure you’re getting the most from it. Also, look for saffron supplements that retain most of its beneficial active compounds like crocin, safranal, and picrocrocin.

    You should check the ingredient label of the saffron extract for the specific amount of these active ingredients. A higher concentration of pure saffron extract is more likely to deliver the benefits you’re seeking. Some brands also provide certificates of authenticity or sourcing information, which may offer extra reassurance about saffron’s quality.

  2. Third-Party Testing

    Third-party testing is a vital factor to consider when choosing a saffron formulation. Reputable brands that use third-party testing send their saffron products to independent laboratories. These labs help verify that the ingredients listed on the label match what’s actually in the bottle.

    Checking for third-party certification is essential because it helps identify any potential problems, such as contamination, inaccurate labeling, or harmful substances that could be present in the product.

    Third-party testing can also confirm that the saffron extract contains the correct percentage of active compounds, like crocin. It is important because the effectiveness of saffron supplements depends on these active compounds.

    Certifications like GMP (Good Manufacturing Practices) or NSF may indicate that the product has passed rigorous testing and meets strict quality standards. These certifications may provide extra reassurance that the saffron supplement is safe for consumption and free from adulterants.

  3. Formulation

    Saffron is typically available in capsule, tablet, or liquid extract form, and the choice between these depends on personal preference and convenience. Capsules and tablets are the most common formats and are easy to include in daily routines.

    However, some may prefer liquid extracts, as they might offer faster absorption into the bloodstream. Some saffron supplements also contain added ingredients like vitamins (such as vitamin B6), minerals, or adaptogens (such as ashwagandha) to enhance mood, reduce stress, or improve sleep quality.

    A good saffron supplement should use pure saffron extract, which includes a potent concentration of active compounds like crocin, crocetin, and safranal. Looking for saffron supplements with added ingredients like black pepper might help your body better absorb and utilize the active compounds in saffron supplements.

    It should also have a formula that may help your body absorb these active ingredients more easily. For example, combining saffron with black pepper or other helpful ingredients

  4. Dosage And Potency

    The recommended daily dose for saffron extract supplements may range from 30 to 100 mg, depending on the concentration of the saffron extract and the intended health benefits. Higher doses might be required for specific purposes like improving mood or supporting weight loss goals.

    It’s important to choose a saffron supplement that provides a consistent and accurate dosage, as this ensures you’re getting the correct amount of active ingredients. Some saffron supplements are standardized to contain a specific concentration of active compounds, which may allow you to know exactly how much crocin, safranal, or picrocrocin you’re consuming.

    Some saffron brands may also offer capsules with time-release technology, which might help the saffron extract remain effective throughout the day. However, you should consult a doctor before taking higher doses of saffron to avoid potential side effects.

  5. Reviews And Reputation

    User reviews offer real-life experiences from people who have used the saffron supplements. They could help provide insights into its effectiveness, ease of accessibility, and any potential side effects.

    A reputable brand is likely to have positive feedback from customers, showcasing its commitment to delivering a high-quality saffron product. However, you should pay attention to both positive/negative reviews of saffron supplements to get a balanced understanding of what to expect.

    You should also consider the overall brand reputation, including how long they’ve been in business and whether they have a clean track record of customer satisfaction.

  6. Price vs. Quality

    The price of saffron supplements typically ranges from $15 to $55 for a one-month supply, depending on the brand, quality, and dosage. Premium saffron supplements with organic or sustainably sourced saffron may cost upwards of $60 or more for a month’s supply.

    Supplements that are too inexpensive may contain lower-grade saffron or additional fillers that dilute the benefits of the product. On the other hand, the most expensive saffron supplements may not necessarily be the best.

    Look for saffron supplements that are priced reasonably for the quality they offer, and avoid products with exaggerated claims or extremely high prices. You should compare several saffron supplements based on their active ingredient content, third-party testing, and reputation to determine if the price is justified.

Frequently Asked Questions

  1. Can Saffron Supplements Interact With Medications?
    Saffron supplements might interact with some medications, particularly antidepressants and blood thinners. You should consult a doctor before starting saffron intake to ensure it won’t negatively affect your current medications or health conditions.
  2. Are All Saffron Supplements The Same?
    Saffron supplement quality might vary depending on the purity of saffron extract, the percentage of active compounds, and whether third-party testing is done.
  3. Can Saffron Supplements Help With Sleep?
    Saffron supplements may help improve sleep quality due to their mood-boosting and stress-reducing effects. Crocin and safranal, essential compounds in saffron, are linked to relaxation, which could support better sleep.
  4. How To Tell If A Saffron Supplement Is Fresh?
    Fresh saffron supplements usually have a distinct color, often a deep red or orange hue. Check the expiration date on the saffron supplement packaging, and store the bottle in a cool, dry environment to maintain its freshness over time.

Conclusion

Saffron supplements could be a suitable addition to your routine, especially if you want to elevate your mood, lower stress levels, or support your weight loss goals. The antioxidant effects of saffron might also support your eye health and improve your complexion.

When selecting a supplement, consider factors like the form of the saffron supplement (capsules, powder, etc.), the purity of the saffron extract, third-party testing, and any certifications the brand has to ensure its safety and potency.

However, you should refrain from using saffron supplements if you’re under 18 years of age or are taking medications like antidepressants or blood thinners. Doing so might help safeguard you against the risk of potential interactions and side effects.

Disclaimer
  • The information in this guide is for informational purposes only and should not be considered as medical advice.
  • It is not recommended to disregard/delay seeking professional medical advice or treatment because of what you read or accessed through this guide.
  • The results may vary from individual to individual.
  • Consult your doctor for any underlying medical conditions or if you are on any prescribed medicines before using any product.

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