Top 10 Quercetin Supplements in 2025

Quercetin supplements might support immunity, reduce inflammation, and combat oxidative stress. The quercetin used in their formulation is derived from plant sources like apples, onions, and berries.

Quercetin is a natural antioxidant that may help regulate your body’s response to allergens, promote heart health, and support overall vitality. Its biological effects could potentially help in reducing histamine release and modulating inflammatory pathways, factors that could be beneficial for seasonal allergies and long-term fitness.

However, choosing the right quercetin supplement may seem tricky. Some products include added ingredients like vitamin C or bromelain that might improve absorption. Others could offer better purity, cleaner formulas, or third-party testing for safety. Paying attention to dosage, ingredient quality, and certifications may help you make an informed choice.

This guide highlights the 10 best quercetin supplements that could suit your needs. We have also evaluated these supplements on factors like their brand credibility and the convenience they offer. Keep reading to learn about the functioning, along with the potential side effects of quercetin products.

10 Best Quercetin Supplements

1. Pure Encapsulations Quercetin

   

   Pure Encapsulations Quercetin could support your immune and cardiovascular function. It provides 500 mg of concentrated quercetin per two capsules, one of the most bioactive flavonoids found in nature.

   As per the official website, Pure Encapsulations Quercetin might help neutralize free radicals that can damage cells and contribute to inflammation. It could also support your cellular health, immune response, and energy levels.

   Pure Encapsulations Quercetin may help regulate histamine levels, which could aid in easing allergy symptoms and promoting a balanced immune response.

   The makers of Pure Encapsulations Quercetin recommend taking two capsules, one to two times daily between meals or as advised by a healthcare provider.
   

   Pros

   • Could support immune system modulation and defense.
   • Might act as a natural antioxidant to reduce free radical damage.
   • May reduce histamine release and ease seasonal allergies.

   Cons

   • May interact with medications like allopurinol.
   • Lack of clarity on formulation for uric acid management.

2. Luma Nutrition Quercetin + Bromelain

   

   According to the official website, Luma Nutrition Quercetin + Bromelain blends 500 mg of pure quercetin with bromelain, which is a natural enzyme that is derived from pineapples known to enhance absorption and complement quercetin’s anti-inflammatory properties. This potent combination may boost immune function, promote a healthy inflammation response, and aid in cellular protection. Formulated with botanical extracts and manufactured in FDA-registered facilities, Luma Nutrition Quercetin + Bromelain claims to adhere to high quality and safety. The makers state that Luma Nutrition Quercetin + Bromelain could help enhance antioxidant defense, ease mild allergies, and support immune balance. It may also help maintain heart health, reduce inflammation, and improve exercise recovery and lung function.
   

   Pros

   • Could support respiratory health and airway function.
   • May help lower inflammation throughout the body.
   • Might enhance exercise endurance and physical performance.

   Cons

   • Might be too potent if you are sensitive, requiring dosage adjustments.
   • Long-term use without medical supervision could lead to side effects.

3. Vital Nutrients Quercetin

   

   Vital Nutrients Quercetin claims to support your body’s natural defense systems. Its two-capsule serving provides 500 mg of Quercetin Dihydrate (95%), a highly bioactive form. Quercetin dihydrate is considered to have decent bioactivity, meaning your body can absorb and use it to some extent. This formula could help maintain healthy oxidation, cardiovascular function, and respiratory balance, especially during seasonal challenges with the help of its immune-modulating and anti-inflammatory properties.

   As per the official website, Vital Nutrients Quercetin may help with allergies, sinus issues, or respiratory discomfort. It could help stabilize mast cells, which may help regulate histamine release and support inflammatory balance.

   The makers state that Vital Nutrients Quercetin might also support the production of glutathione, a key antioxidant involved in detoxification and cellular protection. These actions might help reduce oxidative stress and promote long-term cellular health.

   Vital Nutrients Quercetin could support enzyme activity and help the body respond to environmental stressors while also promoting cardiovascular wellness and seasonal immune resilience.
   

   Pros

   • May support cardiovascular health and improve circulation.
   • Could help regulate blood pressure levels naturally.
   • Might assist in lowering LDL (bad) cholesterol.

   Cons

   • Not formulated with absorption enhancers like bromelain or vitamin C.
   • No taste or flavor, which may be unappealing for some users.

4. aSquared Nutrition Quercetin

   

   According to the official website, aSquared Nutrition Quercetin offers a maximum-strength formula, which may help protect cells from oxidative stress and support immune system regulation. aSquared Nutrition Quercetin delivers 500 mg of Quercetin Dihydrate per capsule, which could support DNA stability and enhance blood flow throughout the body. This formula might help protect neurons from oxidative damage and reduce neuroinflammation.

   aSquared Nutrition ensures quality and purity with a vegan-friendly, gluten-free, soy-free, and dairy-free formula, all made in the USA without preservatives. The makers state that aSquared Nutrition Quercetin could help lower LDL (bad) cholesterol and improve lipid profiles by supporting cardiovascular function, and may also help prevent plaque buildup.
   

   Pros

   • May promote better blood sugar control.
   • Could protect brain cells from oxidative stress.
   • Might support cognitive function in aging populations.

   Cons

   • Only available in capsule form, limiting format flexibility.
   • Could cause digestive issues during the initial use.

5. Now Quercetin With Bromelain

   

   Now Foods Quercetin with Bromelain claims to support seasonal immune function and promote respiratory health year-round. It provides 800 mg of quercetin per two capsules, which may help neutralize free radicals and stabilize mast cells. This formula could also help promote normal respiratory function, making it especially helpful during allergy season.

   Now Quercetin with Bromelain also features 165 mg of bromelain (2400 GDU/g), a natural enzyme sourced from pineapples. Bromelain is known for its ability to support inflammatory balance and aid in digestion. This duo could help the body maintain a healthy immune response to seasonal and environmental challenges while also soothing respiratory discomfort.
   

   Pros

   • May help reduce symptoms associated with prostatitis.
   • Could offer relief from interstitial cystitis discomfort.
   • Might support joint health by modulating inflammatory markers.

   Cons

   • Lacks information on enhanced absorption technologies.
   • You might experience allergic reactions due to the presence of Bromelain.

6. NatureBell Quercetin

   

   As per the official website, NatureBell Quercetin offers a potent bioavailable formula made from a 95% pure 2:1 quercetin extract sourced naturally from Sophora japonica, a legume rich in flavonoids. It provides 500 mg of quercetin dihydrate per capsule, the most absorbable form of quercetin. NatureBell Quercetin claims to deliver maximum flavonoid concentration, which is known for its powerful antioxidant and anti-inflammatory effects. This formula may help combat oxidative stress, support a healthy immune response, and maintain respiratory wellness.
   

   Pros

   • May enhance liver detoxification pathways.
   • Could lower uric acid levels and reduce gout risk.
   • Might improve skin appearance through antioxidant effects.

   Cons

   • Capsules may be too large for some users to swallow comfortably.
   • No clear information about sourcing or the origin of ingredients.

7. Toniiq Quercetin

   

   Toniiq Quercetin provides a potent dose of 1,000 mg of high-grade quercetin per serving. Sourced ethically and produced using an advanced extraction method, this supplement delivers a 95% standardized purity, far exceeding the typical 70% or less. This high level of purity ensures that your body receives a more effective and bioavailable form of quercetin, maximizing the potential health benefits.

   According to the brand, Toniiq Quercetin is designed to help reduce oxidative stress, an imbalance in the body that can damage cells over time. It may contribute to healthier cells and promote longevity by potentially minimizing this damage. This antioxidant action could also be linked to supporting healthy aging, as it aims to preserve cellular function as you grow older. Toniiq Quercetin may aid in immune modulation, which involves helping your immune system stay balanced.
   

   Pros

   • May boost the absorption of resveratrol and other polyphenols.
   • Could have antiviral effects against certain viruses.
   • Might reduce oxidative stress caused by intense exercise.

   Cons

   • The supplement’s high potency may not be suitable for everyone, especially first-time users.
   • Large capsule count per bottle could be intimidating or excessive for casual users.

8. Double Wood Supplements Quercetin

   

   Double Wood Supplements Quercetin with Bromelain may support immune function, metabolism, and cellular health. It provides 1,000 mg of quercetin and 200 mg of bromelain per two capsules.

   According to the makers, Double Wood Supplements Quercetin might help transport zinc across cell membranes. This action could support intracellular zinc levels, especially when taken alongside a zinc supplement, enhancing immune defense and cellular response.

   This formula could also work as an AMPK activator, a metabolic pathway involved in energy regulation, which may help support healthy cholesterol levels and metabolic health.

   The makers highlight that Double Wood’s formula provides you with a 2-month supply, with 60 servings per bottle and recommended usage of two capsules daily with food. It is manufactured in the USA, third-party tested for purity, and also available in a great-tasting gummy form with added zinc for those who prefer chewables.
   

   Pros

   • Could support mitochondrial function and cellular energy.
   • Might help alleviate chronic fatigue symptoms.
   • May reduce allergic responses by stabilizing mast cells.

   Cons

   • No enteric coating or delayed-release system to prevent potential stomach irritation.
   • You might experience mild headaches after using the formula.

9. Sandhu’s Nutrition Quercetin

   

   Sandhu’s Nutrition Quercetin may support immune system function and defend the body against oxidative stress. Made with a 95% standardized quercetin extract derived from Sophora japonica flower buds, this formula may help neutralize free radicals, protect cellular structures, and ease the oxidative load that contributes to aging and chronic health issues.

   As per the makers, Sandhu’s Nutrition Quercetin could help with immune regulation, as it supports the activity of vital immune cells like natural killer cells and T-cells. These cells are central to a balanced immune response, especially during seasonal changes or when exposed to environmental stressors.
   

   Pros

   • Could assist in managing insulin resistance.
   • Might promote a healthier gut environment.
   • Could contribute to healthy aging by supporting cell longevity.

   Cons

   • Absence of synergistic ingredients like bromelain, zinc, or vitamin C for better absorption.
   • No visible certifications like GMP, NSF, or USDA Organic.

10. Doctor’s Best Quercetin Bromelain

    

    Doctor’s Best claims that its Quercetin Bromelain formula combines two scientifically studied ingredients, which might support immune health, joint comfort, and digestive function. Its two veggie capsules deliver 500 mg of quercetin, sourced from the Dimorphandra mollis seed pod, and 250 mg of bromelain.

    This Quercetin Bromelain formula may help regulate immune activity and promote a more balanced inflammatory response. This action could be especially helpful for maintaining healthy circulation and supporting joint comfort, as inflammation often plays a key role in both.
    

    Pros

    • Might protect skin from UV-induced oxidative damage.
    • May improve sleep quality by modulating inflammation.
    • Could aid weight management through metabolic effects.

    Cons

    • Some people might find the pricing of the product higher.
    • Results could vary, and not everyone may experience the same results.

Side Effects of Quercetin Supplements

1. May Trigger Headaches

   Quercetin supplements might increase the likelihood of neurological side effects like headaches. At high doses, quercetin can cross the blood-brain barrier and influence catecholamine levels (dopamine, norepinephrine), which are involved in regulating blood vessel tone in the brain. This can potentially lead to vasodilation or constriction, both of which are common triggers for headaches or migraines. Some research also suggests quercetin may mildly inhibit monoamine oxidase (MAO), potentially disrupting neurotransmitter balance and intensifying headache symptoms, especially if you are sensitive or taking other medications affecting brain chemistry.

2. Stomach upset

   The high concentration of quercetin in supplements can irritate the gastrointestinal tract, particularly when taken on an empty stomach or in poorly formulated capsules. Unlike food-bound quercetin, which is buffered by fiber and other nutrients, isolated quercetin can trigger increased gastric acid secretion, bloating, or nausea. Your body processes quercetin supplements through the liver and small intestine using sulfation and glucuronidation pathways. These pathways may become overwhelmed or produce irritating byproducts at high doses, leading to digestive discomfort in some users.

3. Shortness of breath

   While rare, shortness of breath from quercetin supplements may result from hypersensitivity or immune modulation. Quercetin has anti-inflammatory properties and affects mast cells, which are involved in allergic responses. In some people, particularly if you have asthma or respiratory conditions, this immune interference could paradoxically contribute to airway reactivity or a sensation of breathlessness. Quercetin products may influence mitochondrial activity and cellular oxygen utilization at very high doses, which can reduce oxygen efficiency in tissues.

How Did We Evaluate The Best Quercetin Supplements?

1. Brand Credibility

   One of the core factors in our evaluation was brand reputation, which we assessed through third-party platforms like Trustpilot and the Better Business Bureau (BBB), along with each company’s industry history and transparency.

   Among the other reputable brands, Now Foods leads with an A+ rating from the Better Business Bureau (BBB) and decades of industry presence, though it isn’t listed on Trustpilot.

   Pure Encapsulations follows closely, with an A- BBB rating and a strong professional reputation despite lacking public consumer reviews.

   Double Wood Supplements stands out for transparency, holding an A+ BBB rating and a 3.6 Trustpilot score from over 150 reviews, making it one of the few brands with both consumer feedback and accreditation.

   aSquared Nutrition also carries an A+ BBB rating but has no Trustpilot presence, limiting insight into user experiences. Toniiq shows moderate credibility with a 3.8 Trustpilot rating from 27 reviews, but lacks BBB accreditation.

   Vital Nutrients shares the same 3.8 Trustpilot score, though it’s based on only 2 reviews and is also missing from the BBB database. These brands offer some transparency, but the limited review volume or lack of formal recognition weakens overall trust.

   Brands like Doctor’s Best, Luma Nutrition, NatureBell, and Sandhu’s Nutrition offer little to no third-party validation. None of them are listed on Trustpilot or BBB, making it difficult to assess customer satisfaction, product consistency, or complaint handling.

2. Value for Money

   To assess overall value, we considered what each quercetin supplement offers for the cost, including capsule count, ingredient quality, added synergistic compounds, and brand transparency. Price per capsule can give a clear measure of long-term affordability, especially if you’re planning to take quercetin daily.

   NatureBell Quercetin offers the most cost-effective option at $32.95 for 240 capsules, just $0.14 per capsule, making it suitable for long-term use if you’re after pure quercetin without extras. aSquared Nutrition follows closely with 200 capsules at $34.95 ($0.17 each), appealing mainly to budget users who don’t mind limited brand transparency. Toniiq, priced at $42.47 for 240 capsules ($0.18 per capsule), strikes a good middle ground, likely offering higher potency with better sourcing standards.

   Doctor’s Best provides solid value with its bromelain blend at $35.99 for 180 capsules, working out to $0.20 per capsule. Double Wood also holds up well with a clean, standalone formulation at $24.95 for 120 capsules ($0.21 per capsule), suitable for straightforward supplementation. Sandhu’s Nutrition lands at $29.99 for 120 capsules ($0.25 each) but doesn’t offer the same formulation benefits or brand credibility as similarly priced options. Vital Nutrients costs more at $30.31 for 100 capsules ($0.30 per capsule), justified only if you’re prioritizing professional-grade manufacturing.

   Now Foods includes bromelain at $21.99 for just 60 capsules, making it $0.36 each, decent if you want a reputable brand with combo ingredients, but the count is low. Pure Encapsulations is priced at a premium ($48.40 for 120 capsules, $0.40 per capsule), which may suit users with sensitivities due to its hypoallergenic formulation. Luma Nutrition is the least cost-effective at $39.99 for 60 capsules ($0.66 each), which may only be worth it if you specifically want its bromelain pairing in a compact dose.

3. Refund Policy

   We assessed each Quercetin supplement based on the flexibility, clarity, and consumer-friendliness of its refund policy. Toniiq, Sandhu’s Nutrition, Double Wood Supplements, and Luma Nutrition offered the strongest policies. Toniiq provides a 60-day risk-free guarantee without requiring returns. Sandhu’s allows refunds within 90 days with minimal restrictions. Double Wood lets you keep the first bottle from a multipack and return the rest within 30 days. Luma Nutrition accepts opened and used bottles within a generous 90-day period, though all bottles must be returned.

   Doctor’s Best, NatureBell, Vital Nutrients, and Now Foods offer more standard policies with some limitations. Doctor’s Best provides a 60-day window but lacks detail. NatureBell’s 60-day guarantee applies only in cases of quality issues or health concerns and doesn’t cover return shipping. Vital Nutrients and Now Foods require unopened items to be returned within 30 days, and both place the shipping responsibility on the customer.

   aSquared Nutrition and Pure Encapsulations had the least flexible policies. aSquared only accepts unused, unopened items within 30 days and provides minimal return guidance. Pure Encapsulations is the most restrictive, requiring preauthorization, charging a 15% restocking fee, and only accepting factory-sealed returns within a narrow window.

Frequently Asked Questions

1. Are quercetin supplements safe for people with allergies?
   Quercetin products may help reduce allergy symptoms due to their antihistamine properties. However, if you have sensitivities, you should start with low doses and monitor for adverse effects like rash or breathing issues.
2. What form of quercetin supplement is most effective?
   Quercetin dihydrate and phytosome forms are among the most effective. Phytosomes may offer superior absorption, but dihydrate is the most studied and commonly used.
3. Are all quercetin supplements sourced from the same plant?
   No, while many quercetin products use Sophora japonica (Japanese pagoda tree), some may source quercetin from onions, apples, or other botanicals. The source may affect the purity and bioflavonoid content.

Conclusion

Quercetin supplements offer a useful way to achieve concentrated doses, often 500 to 1,000 mg per serving, that are difficult to obtain through diet alone. To improve their bioavailability, many formulas include absorption enhancers like bromelain or supporting nutrients such as zinc.

The 10 best Quercetin supplements discussed in this guide vary in approach, as some prioritize purity, while others aim for broader immune or respiratory support.

Despite its promising biological activity, the clinical evidence of quercetin’s effectiveness remains inconsistent. Individual results can vary based on formulation, dosage, and health status.

While generally well-tolerated, higher doses of quercetin products may lead to side effects such as headaches, digestive discomfort, or, in rare cases, shortness of breath. These supplements may also interfere with certain medications by affecting liver enzyme activity.

If you’re considering quercetin supplements, it’s important to consult a medical provider, especially if you’re managing chronic conditions or taking prescription drugs.

You can also boost your daily quercetin intake by incorporating more quercetin-rich foods into your meals. Onions, apples, berries, and leafy greens naturally contain this flavonoid, often alongside other phytonutrients that may enhance its effectiveness and absorption.

These whole-food sources could offer a more balanced and sustainable way to support your fitness, with potentially fewer side effects than high-dose supplements. This approach may work well on its own or as a complement to supplementation, depending on your individual needs.