7 Best NAD+ (NMN) Supplements In 2024

Nicotinamide adenine dinucleotide (NAD) might help support your health and longevity. You can naturally increase your NAD levels through your diet, but taking NAD+ (NMN) supplements may support you with enhanced effects.

Nicotinamide Mononucleotide (NMN) is known as a natural molecule that may help your body produce NAD+. It is believed to support important functions in your cells, such as DNA repair, immune health, and metabolism. However, as you get older, your NAD+ levels can slowly decrease.

With so many NMN supplements available, it can be hard to find one you can trust. That’s why we’ve reviewed and ranked the top 7 NMN supplements for you.

We’ve examined their benefits, possible side effects, dosages, and more to help you make the best choice. In this guide, we’ll discuss the potential benefits and risks of including an NMN supplement in your routine and highlight some of the best options available.

What are NAD+ (NMN) Supplements?

NAD+ (nicotinamide adenine dinucleotide) supplements, often referred to as NMN (nicotinamide mononucleotide) supplements, could boost the body’s levels of this essential coenzyme. It may help with cellular metabolism, energy production, and DNA repair. NAD+ helps in activating sirtuin proteins that coud regulate cellular health, promote DNA repair, and may have anti-aging effects. NAD+ levels naturally decline with age, which could lead to reduced cellular efficiency and an increase in age-related conditions, such as decreased energy levels, cognitive decline, and a weakened immune response. NMN supplements claim to help restore these declining NAD+ levels, supporting vital biological processes essential for maintaining overall health. These supplements are derived from nicotinamide and ribose, which serve as building blocks for NAD+ synthesis in the body.

7 Best NAD+ (NMN) Supplements

1. partiQlar Pure NMN

   

   PartiQlar Pure NMN may help boost your energy levels, cognitive function, and metabolic health. The official site states that the manufacturing practices are FDA-registered and GMP-certified, providing assurance of the PartiQlar Pure NMN’s quality.

   The makers claim that NMN may support essential cellular processes by enhancing NAD+ availability, potentially promoting DNA repair and improving insulin sensitivity.

   PartiQlar Pure NMN may work by boosting energy levels by increasing NAD+ (Nicotinamide Adenine Dinucleotide), which is essential for mitochondrial function and optimal energy production in your cells. This could improve overall energy and activity levels throughout the day.

   PartiQlar Pure NMN claims to enhance endurance and strength, allowing you to perform better during physical activities and aiding in muscle recovery.

   It is also believed to support DNA repair, which is crucial for maintaining cellular health, especially as you age, potentially preventing age-related decline.

   NMN may improve insulin sensitivity, which is vital for managing blood sugar levels and could lower the risk of developing type 2 diabetes.

   It may promote brain health by reducing oxidative stress and inflammation, potentially improving cognitive function and memory, and potentially protecting against neurodegenerative diseases.

   Key Ingredients of partiQlar Pure NMN

   Nicotinamide mononucleotide

   Research suggests that NMN may help boost energy production in cells, improve how our mitochondria (the energy factories of cells) work, and support metabolic health. It may improve muscle function and endurance, which could be helpful for active individuals wanting to boost their physical abilities. It may also support healthy aging through its function in activating sirtuins proteins that boost longevity.

   Pros & Cons

   Pros

   • It claims to have 99% purity, which might support in cognitive and metabolic health.
   • It is said to be made in certified facilities that follow strict safety rules.
   • You can get a discount if you sign up for a 12-month subscription, helping you save money.
   • Users often feel more energetic, which helps with overall health.
   • If you’re not satisfied, you can get your money back within 60 days.
   • It may help improve your metabolism, supporting better energy use in the body.

   Cons

   • You can only buy it from the PartiQlar website, making it hard for some people to purchase it.
   • Some users might have mild stomach problems after taking it.
   • There isn’t much information about the safety of using NMN for a long time.

2. Omre NMN + Resveratrol

   

   Omre NMN + Resveratrol claims to combine two potent compounds known for their synergistic effects on health. It comes with nicotinamide mononucleotide (NMN) and resveratrol in a convenient daily capsule, promoting cellular energy and wellness.

   The combination of NMN and resveratrol may help elevate NAD+ levels in the body, a crucial factor in metabolic processes and cellular repair.

   NMN is effectively absorbed by cells, converting into NAD+, which may help restore cellular functions and improve mitochondrial metabolism.

   Resveratrol, a naturally occurring antioxidant found in foods like red grapes, complements this by potentially enhancing sirtuin activity, further supporting NAD+ production.

   The makers recommended taking Omre NMN + Resveratrol with fat-rich foods, as resveratrol is fat-soluble, ensuring better absorption.

   While the price may seem high, the dual-action formulation could provide significant value, particularly for individuals committed to their longevity journey.

   Omre NMN + Resveratrol comes with a 30-day return window, which could be a factor to consider as other competing companies offer a return window of 60 days or more.

   Key Ingredients of Omre NMN + Resveratrol

   Nicotinamide mononucleotide

   Nicotinamide mononucleotide (NMN) may produce nicotinamide adenine dinucleotide (NAD+), which is said to be essential for energy production, DNA repair, and cell communication. It could help boost NAD+ levels, supporting overall health. NMN may improve energy production, enhance physical performance, and support brain function.

   Resveratrol

   Resveratrol is a natural compound known for its critical antioxidant properties, which help protect cells from oxidative stress. It might support heart health by improving blood vessel function and reducing inflammation. It could help lower blood pressure and improve cholesterol levels, potentially decreasing heart disease risk. Resveratrol may activate sirtuins, proteins linked to longevity and metabolic health, promoting healthier aging. It might enhance cognitive function and memory by reducing neuroinflammation.

   Bioperine

   Bioperine, a patented extract from black pepper, may boost the absorption of various nutrients and supplements. This natural compound contains piperine, which could enhance the absorption of vitamins and minerals, making supplements more effective. When combined with NMN, Bioperine may help ensure optimal nutrient absorption and usage in the body. The benefits of adding Bioperine to NMN supplements include improved absorption rates, which might lead to more effective cellular uptake. It may enhance the health benefits linked to NAD+ production, supporting energy metabolism and overall vitality. Research shows that Bioperine could help increase the bioavailability of compounds by up to 30%.

   Pros & Cons

   Pros

   • It may help increase energy levels and make you feel more lively.
   • It may help protect your body frome excessive stress and age-related fatigue.
   • It claims to contain pure ingredients (over 98%).

   Cons

   • It usually costs around $59.97 per bottle, which might be too expensive for some people.
   • The way resveratrol works with NMN is not fully understood, and it could cause problems in some cases.
   • You can only buy it from the Omre website, which may not be convenient for everyone.
   • There isn’t much long-term safety information available, so you should be cautious with long-term use.

3. ProHealth NMN Pro™ Powder

   

   ProHealth NMN Pro™ Powder claims to provide 250 mg of 100% pure NMN. The makers claim that ProHealth NMN Pro™ Powder may support NAD+ levels and healthy aging. It could also improve heart health and increase muscle strength. They suggest that it can boost various aspects of health, such as physical endurance, muscle strength, brain function, heart health, body weight, and gene activity. According to them, nicotinamide mononucleotide (NMN), which comes from the B-vitamin niacin, acts as a building block for NAD+, potentially leading to significant improvements in health and longevity. They also claim that as NAD+ levels decline with age, adding ProHealth NMN Pro™ Powder may help restore these levels and prevent related cognitive issues.

   Key Ingredients of ProHealth NMN Pro™ Powder

   Uthever® β-Nicotinamide Mononucleotide

   Uthever® β-Nicotinamide Mononucleotide (β-NMN) may help ensure optimal absorption in the body. It may promote DNA repair and cellular resilience, potentially mitigating age-related decline. It is also said to be linked to improved insulin sensitivity and energy metabolism, contributing to overall well-being.

   Pros & Cons

   Pros

   • ProHealth NMN Pro™ Powder offers 250mg of pure Nicotinamide Mononucleotide (NMN) per serving.
   • You can choose different quantities and subscription options, giving you flexibility in your health routine.
   • It is claimed to be free from any fillers or additives.
   • There is a 100-day money-back guarantee, so you can try NMN without worrying about losing money if it doesn’t work for you.

   Cons

   • You can only buy this product on the ProHealth website, which may be inconvenient if you prefer shopping at different stores.
   • Taking one scoop 1 to 4 times a day could be hard for people with busy schedules or for those who may forget to take their supplements.
   • The lack of a monthly subscription might discourage regular users who prefer automatic deliveries for convenience.
   • NMN is usually well-tolerated, but some people might experience mild stomach discomfort. It is important to watch for any side effects.

4. Lifeforce Peak NMN

   

   Lifeforce Peak NMN claims to enhance cellular health and promote longevity. NMN is known as a key precursor to NAD+ (nicotinamide adenine dinucleotide), which is important for energy production, DNA repair, and cell regeneration.

   It claims to focus on boosting NAD+ levels, which may improve mitochondrial function in organs like skeletal muscle, liver, heart, and eyes.

   The makers emphasize high quality, using NMN that is tested for 99% purity and stability. It includes Lithium Orotate, which might support mood and help manage stress.

   Lifeforce Peak NMN aims to improve energy metabolism, support healthy cellular aging, and enhance overall health. It may help manage fatigue, cognitive decline, and physical stress. It is said to be backed by third-party testing to ensure safety and potency.

   It is claimed to be free from synthetic fillers and artificial preservatives. Lifeforce Peak NMN may also support neuroprotective pathways for long-term brain function and aid in DNA repair, which could promote cellular health and longevity.

   Key Ingredients of Lifeforce Peak NMN

   Berberine HCl

   Berberine HCl is a powerful bioactive alkaloid that might regulate glucose metabolism and improve insulin sensitivity. It may lower total cholesterol and triglyceride levels, thereby promoting cardiovascular health. Berberine’s anti-inflammatory properties may contribute to overall well-being by reducing systemic inflammation. It may activate the AMP-activated protein kinase (AMPK) enzyme that plays a critical part in cellular energy homeostasis.

   White Mulberry Extract

   White Mulberry Extract has been studied for its potential to address blood sugar levels and improve insulin sensitivity. It contains active compounds like flavonoids, alkaloids, and vitamins that may provide antioxidant properties. Research suggests that White Mulberry Extract could lower postprandial glucose levels, supporting metabolic regulation. It might also aid in weight management by enhancing metabolic rate and potentially assisting with weight loss efforts. This extract may reduce oxidative stress, promoting overall health. It might improve lipid profiles, supporting cardiovascular wellness.

   Pros & Cons

   Pros

   • Lifeforce Peak NMN has 99% purity, which means it sets a high standard for quality and may be more effective for health benefits.
   • It includes mulberry extract, which might help with healthy blood sugar regulation, supporting metabolic health.
   • It might increase NAD+ in the body, which plays a key role in energy production and metabolism. This may improve memory and support healthy aging.
   • Lifeforce offers a subscription option that can save you 20% each month, making it a more cost-effective choice for long-term use.

   Cons

   • It could be considered more expensive than others,
   • You need to take three capsules a day, which some users may find excessive or inconvenient.
   • Some users might experience mild stomach issues, which could make it harder to keep using the supplement consistently.

5. Doublewood NMNH Supplement

   

   Double Wood’s NMNH might enhance NAD+ production, supporting vitality, cognitive function, and cellular rejuvenation. With 250 mg of NMNH per serving, it potentially claims to provide you with a faster absorption rate. Double Wood’s NMNH is also non-GMO, vegan, and gluten-free, which could also make it suitable for people with specific dietary preferences. Its formulation is said to be free from synthetic fillers. Double Wood’s NMNH might help raise NAD+ levels that promote brain health, cardiovascular function, and overall energy levels. It is claimed to be backed by a 30-day money-back guarantee, which may provide you with a month to assess its effects on your health.

   Key Ingredients of Doublewood NMNH Supplement

   NMNH (Dihydronicotinamide Mononucleotide)

   NMNH is a reduced form of Nicotinamide Mononucleotide (NMN) that may enhance NAD+ synthesis. Its unique biochemical properties may facilitate improved mitochondrial function and overall vitality.

   Pros & Cons

   Pros

   • Doublewood NMNH is said to be non-GMO and made in the USA, which may ensure high-quality ingredients.
   • The Doublewood NMNH makers claim hat their quality is confirmed by third-party testing.
   • Doublewood NMNH may improve cognitive function, boost energy levels, and support healthy aging.
   • Doublewood NMNH is safe for vegans.

   Cons

   • Users might have to wait longer to see noticeable effects.
   • Taking two capsules daily may feel like too much for some people, leading to reluctance in following the recommended dosage.
   • While generally well-tolerated, some users may experience mild stomach issues.

6. GenuinePurity Liposomal NMN

   

   Genuine Purity’s Liposomal NMN claims to significantly enhance the absorption and bioavailability of Nicotinamide Mononucleotide (NMN). It comes in a lipid layer, allowing for more efficient nutrient uptake and ensuring optimal absorption. Each serving contains 250 mg of NMN, which, while lower than some alternatives, could help in promoting cellular repair, energy production, and longevity. Genuine Purity also claims to emphasize purity and safety, utilizing non-GMO ingredients and avoiding synthetic additives. Genuine Purity also provides you with competitive pricing, typically retailing at $69 per bottle, with discounts available for bulk purchases. Their 97-day money-back guarantee could also be a good factor to consider, which may allow you to assess the product’s efficacy over time.

   Key Ingredients of GenuinePurity Liposomal NMN

   Dihydronicotinamide Mononucleotide

   Dihydronicotinamide Mononucleotide (DHNM) is known as a derivative of NMN that potentially helps in enhancing cellular metabolism and energy production. As a precursor to NAD+, DHNM may support the synthesis of this critical coenzyme, which is vital for numerous biochemical reactions within the body, including energy metabolism and DNA repair. DHNM could enhance mitochondrial function, which is essential for optimal energy production in cells. It has been linked to potential neuroprotective effects. It may also help mitigate oxidative stress and inflammation experienced in neurodegenerative conditions. While current studies are promising, more comprehensive clinical trials are required to understand the long-term effects and benefits of DHNM fully.

   Pros & Cons

   Pros

   • Provides a scientifically supported amount of NMN that may help with cellular health and energy.
   • It’s free from gluten, soy, grain, sugar, and dairy, making it suitable for many diets. This may allow more people to use it without issues.
   • Offers free shipping, which enhances accessibility for users.
   • A 97-day money-back guarantee allows you to try it risk-free, which may help build trust in the product.

   Cons

   • The NMN purity is lower compared to other brands, which might affect how well it works.
   • At $69 per bottle, it could be too expensive for those on a budget, making regular use harder.
   • There isn’t much information about the long-term safety of NMN, so potential users should be cautious.
   • Some users might experience mild stomach issues or rare allergic reactions, which could discourage continued use.

7. Wonderfeel Youngr™ NMN

   

   Wonderfeel Youngr™ NMN claims to provide you with a high-quality source of Nicotinamide Mononucleotide (NMN), which is vital for the production of NAD+ coenzyme essential for cellular metabolism and energy production.

   Each capsule of Youngr™ NMN contains 450 mg of NMN, with a recommended daily intake of two capsules totaling 900 mg. This dosage exceeds the typical range of 100-350 mg found in other products but is generally well-tolerated and has been backed by research indicating that users often experience positive health outcomes.

   Youngr™ NMN includes ergothioneine, trans-resveratrol, olive fruit extract, and vitamin D3, all encased in a vegetable cellulose shell, ensuring its suitability for vegans.

   While the price may seem expenisve, $88 for a one-time purchase or $73 for a subscription, you can check the official website for promotional offers and select as per your needs and budget.

   Key Ingredients of Wonderfeel Youngr™ NMN

   Vitamin D

   Vitamin D, known as a fat-soluble vitamin, may support bone health. It may enhance calcium absorption in the gut. It may help in healthy immune function, muscle health, and regulating inflammation, which is essential for overall well-being. Adequate Vitamin D levels may help prevent chronic diseases, as deficiency could be linked to conditions like osteoporosis, cardiovascular disease, and certain cancers. Optimal Vitamin D levels might also support metabolic health and enhance insulin sensitivity.

   Olea25

   Olea25 could support the body’s natural production of NAD+ and may help increase energy availability within cells. The antioxidant properties of oleuropein might also combat oxidative stress, which is known as a major contributor to aging and chronic diseases. Clinical studies have indicated that Olea25 may improve various health parameters, including blood pressure regulation and insulin sensitivity. Its anti-inflammatory effects could protect against chronic inflammatory conditions.

   Trans-Resveratrol

   Trans-resveratrol is known for its potential antioxidant properties that may neutralize harmful free radicals in the body, It might activate sirtuins proteins linked to longevity and metabolic regulation, potentially promoting cellular repair and metabolic health. Some studies also suggest that trans-resveratrol may support cardiovascular health by improving endothelial function and reducing inflammation. It might have neuroprotective effects that could aid cognitive function and memory retention.

   Pros & Cons

   Pros

   • It contains Trans-Resveratrol that may help with aging and heart health, making the supplement potentially more effective.
   • It is made with vegan ingredients, so it’s good for plant-based diets.
   • Made in facilities that follow strict quality controls in the U.S., ensuring high standards.

   Cons

   • Costs $88 per bottle without a subscription or $73 per month with a subscription, which could expensive for some people.
   • Some users might have mild stomach issues, which could make them stop using it.

Benefits of NMN supplements

NMN supplements may enhance muscle function by increasing energy production in cells. They could improve endurance and overall physical performance, making it easier for people to engage in exercise and daily activities.

NMN might boost the metabolic rate, which could help the body burn calories more efficiently. A higher metabolism may aid in weight management by promoting fat loss and preventing additional weight gain.

NMN supplements could support heart health by improving blood flow and vascular function. This support could reduce the risk of heart disease and promote better circulation, contributing to overall wellness and

Benefit	Description
Improved Muscle Function	Enhances physical activity and endurance.
Enhanced Metabolism	Boosts metabolic rate, potentially aiding weight management.
Cardiovascular Support	Promotes better cardiovascular health and function.

Side effects of NMN supplements

Although generally well-tolerated, some individuals may experience mild adverse effects, particularly at higher doses. Potential side effects of NMN supplementation may include:

• Headaches
• Diarrhea
• Nausea
• Indigestion
• Fatigue

It is essential to understand that not everyone will experience these side effects, especially when starting with lower doses. Many users report no adverse effects at all, particularly when they gradually increase their intake. Nonetheless, it remains crucial to monitor one’s body’s response and consult with a doctor if any discomfort arises.

How to choose the best NAD+ (NMN) Supplements?

1. Security

   When choosing the best NAD+ (NMN) supplements, safety should be a top priority. It’s essential to look for products that independent labs test for purity and potency. Check the labels to ensure they provide clear and accurate information about the amount of NMN and any other ingredients included. Opt for trusted brands with positive customer reviews to avoid unreliable manufacturers. Additionally, select supplements made in facilities that follow Good Manufacturing Practices (GMP) to guarantee quality. Reputable companies often offer satisfaction guarantees, which reflect their confidence in the safety of their products.

2. Effectiveness

   Recent research highlights the benefits of NMN in increasing NAD+ levels, which are vital for energy production and DNA repair. By enhancing NAD+ availability, NMN supplements may improve cellular function and promote healthy aging. While animal studies show promising health benefits, including lifespan extension, more human trials are needed to understand the long-term impact and potential uses of NMN fully. The dosage and form of NMN supplementation can also influence its effectiveness. Research indicates that common dosages range from 250 mg to 1000 mg per day, and individual responses may vary based on specific health goals and physiological factors.

3. Cost

   The cost of NMN supplements can vary widely. Several factors influence the cost, such as the brand’s reputation, purity testing, and the type of formulation. Well-known brands might come at a higher price point more due to their premium quality. Products that undergo third-party testing for purity often come at a higher price. Different forms of NMN, like capsules or powders, can also affect costs. It’s important to balance quality with affordability to make an informed purchase.

4. Convenience

   Convenience could also play a significant role in the effectiveness of NMN supplements. They are available in various forms, including capsules, powders, and sublingual tablets, allowing you to choose what fits best with your lifestyle. Capsules and tablets could be more accessible to take on the go, while powders offer flexibility in serving sizes and can be mixed into drinks. Sublingual tablets may provide better absorption since they go directly into the bloodstream. Consider the timing of your NMN intake, as some brands offer specialized formulations to enhance absorption, making it easier to add them to your daily routine.

5. Dosage

   Finding the right dosage of NMN supplements is crucial for maximizing benefits and ensuring safety. Common dosages range from 250 mg to 1000 mg per day, but individual needs can vary based on health goals and conditions. Always consult with your doctor before starting NMN supplementation to determine the appropriate NMN dosage for you. It may be helpful to talk to your doctor as they could suggest starting with a lower dosage pattern and slowly increasing it to assess how the body may respond. Monitoring any changes in energy levels or overall well-being can help you adjust the dosage as needed.

Frequently Asked Questions

1. Can NMN Supplements Be Taken With Other Medications?
   NMN supplements may interact with certain medications, affecting their efficacy or side effects.
2. Are There Specific Dietary Recommendations While Taking NMN?
   While taking NMN, a balanced diet rich in antioxidants, healthy fats, and vitamins is recommended. Hydration and moderation in processed foods can enhance metabolic benefits and support overall health, optimizing NMN’s potential effects on well-being.
3. How Long Does It Take to Notice NMN Effects?
   The timeframe to notice effects from NMN supplementation varies individually, typically ranging from a few weeks to several months. Factors influencing this include dosage, consistency of use, metabolic health, and individual physiological responses.
4. Is NMN Safe for Long-Term Use?
   The long-term safety of NMN supplementation remains under investigation. While generally well-tolerated with few side effects, comprehensive studies are necessary to fully understand its prolonged effects and ensure safety over extended periods of use.
5. Can Athletes Use NMN Supplements?
   NMN supplements may benefit athletes by enhancing cellular energy production, improving endurance, and supporting recovery. However, individual responses can vary, so athletes should consult healthcare professionals to tailor supplementation to their specific needs and goals.

Conclusion

Selecting the best NAD+ (NMN) supplements can significantly impact your health and vitality. With a wide range of options available, it’s essential to consider effectiveness, safety, and convenience when making your choice. The top seven supplements highlighted in this guide are recognized for their premium quality, independent testing, and positive consumer feedback. To further support the benefits that NMN supplements claim, consider making simple lifestyle changes, such as maintaining a balanced diet, engaging in regular physical activity, staying hydrated, and managing stress through mindfulness or relaxation techniques. These practices can enhance cellular health and energy levels, complementing the effects of NMN supplementation. Always talk to a health expert before starting any new NMN supplement to make sure it fits your health needs and goals.