Best 7 DHEA Supplements for Men for Hormonal Support In 2025

Dehydroepiandrosterone (DHEA) is known as a naturally occurring hormone made by the adrenal glands in your body, which helps support the production of essential hormones like testosterone and estrogen.

With age, the natural DHEA production declines in men, which may contribute to signs like reduced strength, fatigue, lowered libido, and decreased bone density.

DHEA supplements are commonly used to support the body’s hormone balance and may help counteract some of these age-related hormonal changes.

However, with various DHEA formulations available in the market, what factors should you consider before opting for a DHEA supplement? In this review, we compiled a list of the 7 best DHEA supplements available. The review also covers some potential side effects of DHEA supplementation.

7 Best DHEA Supplements

1. Pure Encapsulations – DHEA 25MG

   

   Pure Encapsulations DHEA 25 mg contains a micronized form of dehydroepiandrosterone (DHEA). The micronization process may help reduce the particle size of DHEA, which may enhance its bioavailability and absorption.

   DHEA may help stimulate the synthesis of testosterone and estradiol hormones, which may positively impact physiological processes like reproductive function, energy metabolism, immune response, and mood stability.

   Supplementing DHEA may tackle adrenal insufficiency symptoms, which might help elevate mood, enhance libido, and support metabolic function. When taken alongside lifestyle interventions like calorie restriction and exercise, DHEA formulations may also help support increased fat-burning and boost energy metabolism.

   According to the official site, Pure Encapsulations DHEA 25 mg does not comprise common allergens, such as wheat, eggs, GMOs, unnecessary binders, tree nuts, etc.
   

   Pros

   • Could help support a healthy immune response and provide antioxidant support.
   • May help maintain healthy lean muscle–to–fat ratio.
   • Has a hypoallergenic formula free from allergens like soy, dairy, fillers, and gluten.
   • Comes in two options, with servings of 60 and 180 capsules per bottle.

   Cons

   • May trigger side effects like irritability, acne, and oily skin.
   • Could elevate blood pressure levels and lower HDL (good) cholesterol levels.

2. Horbaach – DHEA 100mg Capsules

   

   As per the official site, DHEA 100 mg capsules by Horbäach provide a quick-release form of dehydroepiandrosterone (DHEA), which may offer faster DHEA absorption than standard capsules. Horbäach’s DHEA formulation may help support energy metabolism, muscle health, and cognitive function.

   Horbäach claims that the DHEA 100 mg capsules are manufactured following Good Manufacturing Practices (GMP), indicating stringent quality control standards and manufacturing processes. The makers suggest consuming one Horbäach DHEA 100 mg capsule daily with water, preferably alongside a meal.

   According to the official site, Horbäach’s DHEA 100 mg is formulated without common allergens, such as lactose, GMOs, artificial colors, or harmful preservatives. Horbäach also states that the DHEA 100 mg capsules should be avoided in case you have an enlarged prostate, heart disease, low good cholesterol (HDL), or are taking prescription medications.
   

   Pros

   • May support increased focus and elevate mood.
   • Offers 200 capsules per bottle, ensuring a long-lasting supply of DHEA.
   • May help improve bone density and support muscle function.

   Cons

   • Variations in results and effectiveness.
   • May trigger signs of hormonal imbalance, such as mood swings, fatigue, and aggression.

3. Nurticost – DHEA Capsules

   

   According to the official site, the Nutricost DHEA Capsules come in doses of 25 mg, 50 mg, and 100 mg of DHEA per capsule. Nutricost also provides added dosing convenience by providing options to select from two bottle options, with either 120 or 240 capsules per bottle.

   Research studies indicate that DHEA may stabilize the body’s cortisol levels (a stress hormone). Such effects may help support a healthy metabolism, lower fatigue, and help preserve lean muscle mass that typically declines with age.

   Supplementing with Nutricost DHEA Capsules may also support cognitive health, as your body metabolizes DHEA into brain-supporting compounds called neurosteroids. These compounds may help improve your mood and brain function by stimulating the release of brain neurotransmitters like serotonin and dopamine, which may increase feelings of happiness and lower elevated stress levels.
   

   Pros

   • Undergoes third-party lab testing by ISO-accredited labs to check for formulation purity and safety.
   • Offers a 60-day money-back guarantee on purchases.
   • Subscribing to Nutricost can save an extra 20% on the retail price.
   • Could help minimize age-related decline in DHEA levels.

   Cons

   • May trigger or worsen anxiety episodes.
   • Could lead to adverse gastrointestinal effects, such as bloating and stomach upset.

4. Puritan’s Pride – DHEA Tablets

   

   According to the official site, Puritan’s Pride DHEA Tablets come in 3 different potencies 25mg, 50mg, and 100mg of DHEA per tablet. DHEA may help support the synthesis of vital hormones like testosterone and estrogen, which could positively impact your fertility, energy metabolism, and hormonal balance.

   Puritan’s Pride DHEA Tablets may help support a healthy sugar metabolism. Research studies indicate that a daily intake of 50 mg DHEA in older adults (between 65-75 years of age) enhances insulin sensitivity and glucose processing. The findings may suggest that DHEA intake could help improve insulin sensitivity, which might help lower the risk of concerns like type 2 diabetes.

   The makers suggest consuming one Puritan’s Pride DHEA tablet daily to counteract the natural decline in DHEA levels associated with aging. As per the official site, Puritan’s Pride DHEA tablets do not comprise allergens like artificial colors, preservatives, gluten, yeast, starch, etc. Such a composition may increase Puritan’s Pride DHEA compatibility for diverse dietary needs.
   

   Pros

   • Offers schemes like “Buy 1 Get 2 Free” and “Buy 2 Get 4 Free” for better cost-effectiveness.
   • May help lower stress levels and anxiety.
   • Could help improve free testosterone levels, especially in middle-aged men (40 years or above).
   • May help reduce fatigue and improve endurance.

   Cons

   • Many consumers observed no noticeable improvements in energy, libido, or focus, even after weeks of consistent use.
   • Could trigger insomnia, making it hard for some users to fall or stay asleep.

5. Vitacost – DHEA 25 mg Capsules

   

   As per the official site, one Vitacost DHEA capsule provides 25mg of DHEA, which comes in bottles with 100 and 300 capsules. The formulation could help support hormone balance, promote immunity, and support healthy adrenal gland function.

   DHEA may act as a neurosteroid in the brain, influencing GABA and NMDA receptors. Such a mechanism may positively impact mood regulation and support a healthy stress response. Vitacost DHEA formulation may also improve bone mineral density by increasing estrogen and androgen hormone levels.

   One jar of Vitacost 25 mg DHEA Capsules costs $6.99 for the 100-capsule bottle and $17.99 for the 300-capsule bottle. Vitacost also offers subscription purchase options, which are available in delivery intervals of 15, 30, 45, 60, 90, and 120 days.
   

   Pros

   • Could help reduce harmful free radical molecules and provide antioxidant support.
   • Offers a convenient one‑capsule daily serving.
   • Manufactured under strict FDA‑cGMP guidelines to ensure quality and safety.

   Cons

   • May worsen prostate-related issues by stimulating prostate tissue growth.
   • Could elevate DHT levels, potentially leading to hair thinning or male-pattern baldness.

6. Toniiq – DHEA 99%

   

   Toniiq’s DHEA 99% aims to support healthy adrenal gland function, cardiovascular function, and the body’s natural immune defenses. As per the official site, one capsule provides 100 mg of micronized dehydroepiandrosterone (DHEA), which may offer improved absorption and bioavailability of DHEA.

   DHEA 99% by Toniiq could support a healthy immune response, reduce inflammation, and enhance resilience to stress. The research found that DHEA may enhance nitric oxide (NO) synthesis in endothelial cells, promoting vasodilation and improved blood flow. It may also help maintain arterial flexibility and reduce vascular inflammation.

   Toniiq claims that each batch of its DHEA 99% undergoes a 5-Point Testing Program. It includes third-party testing to check for microbial contamination, heavy metals, accurate dosage (assay), and active ingredient integrity in both the raw material and finished product. Toniiq recommends taking one DHEA 99% capsule daily, preferably with meals.
   

   Pros

   • May help improve libido and sexual function.
   • Could lower SHBG levels, making testosterone more bioavailable.
   • Might support erectile function by promoting nitric oxide production.

   Cons

   • Prolonged use may worsen liver function markers and potentially harm liver health.
   • May raise estrogen levels in men, causing gynecomastia (breast tissue enlargement).

7. GNC – DHEA Supplement

   

   According to the official site, one tablet of the GNC DHEA supplement provides 25 mg of DHEA. One bottle provides 90 tablets, which may last a 3-month supply when taken in the recommended dose of one capsule per day. The GNC DHEA formulation may delay the natural DHEA decline associated with aging, improve energy levels, and elevate mood.

   Research has found that DHEA may stimulate osteoblast activity (bone-building cells) and suppress osteoclast activity (bone-resorbing cells). It may also support the production of insulin-like growth factor 1 (IGF-1).

   As per the official site, one bottle of GNC DHEA 25 mg formulation is available at $14.99 as part of a one-time purchase. Opting for a GNC subscription reduces the cost per bottle to $13.49.
   

   Pros

   • May aid in healthy fat metabolism and support fitness goals.
   • Could help support better memory and focus with consistent use.
   • Might promote cardiovascular health by improving endothelial function.
   • Offers free shipping on purchases worth $59 or more.

   Cons

   • May increase homocysteine levels, a cardiovascular risk marker.
   • Could negatively impact thyroid hormone levels, particularly by lowering TSH levels.

What Are DHEA Supplements?

DHEA supplements are dietary formulations that may support sexual health, cognitive function, metabolism, hormonal balance, etc.

With age (typically after mid-30s), DHEA levels typically decline, which may require the need for supplementation. DHEA supplements may come in various formats, including capsules, tablets, sublingual lozenges, and powders. Each form may differ in its rate of absorption and ease of use, and you may choose them based on personal preference or targeted benefit.

A double-blind, placebo-controlled trial explored the effects of DHEA supplementation in middle-aged men. In this study, men aged 50–65 years took 100 mg of DHEA daily for six months. The results found that DHEA supplementation successfully increased DHEA and DHEA-S (its sulfated form) to youthful levels and elevated the DHEA-S to cortisol ratio, which is an important marker of adrenal health and hormonal balance.

It is important to note that there was no significant increase in downstream androgens like testosterone or DHT despite the rise in DHEA levels. It may suggest that the impact of DHEA supplements on testosterone is minimal, especially if your baseline T levels are within the normal range.

Side Effects Of DHEA Supplements

1. Acne And Oily Skin

   When you take DHEA formulations, your body converts DHEA into testosterone and dihydrotestosterone (DHT). Both of these androgens may increase oil (sebum) production by helping stimulate the sebaceous glands in your skin. Excessive sebum production may clog your pores, allowing bacteria like Cutibacterium acnes to grow, which triggers inflammation and acne breakouts.

   DHT may bind to androgen receptors in your skin and ramp up oil gland activity, especially in areas like your face, back, and shoulders. If you’re already prone to acne, DHEA supplements may aggravate your condition and lead to persistent breakouts and excessive shine.

2. Hair Loss

   DHEA supplementation may raise levels of dihydrotestosterone (DHT), which is an androgen hormone linked to hair loss. It happens when DHEA gets converted into DHT by the enzyme 5α-reductase, especially in the skin and scalp. Higher DHT levels may shrink hair follicles in genetically sensitive areas, such as the temples and crown, shortening the hair’s growth phase and producing thinner, weaker hair strands.

   Over time, high DHT levels may contribute to gradual hair thinning and male-pattern baldness. In many cases, the process is not reversible. If hair loss runs in your family, using DHEA formulations might speed up the condition by increasing androgen activity in your scalp follicles.

3. Breast Tissue Growth

   DHEA supplementation may cause an increase in estrogen levels through a process called aromatization. When your body has more testosterone than it needs, the aromatase enzyme converts some of it into estradiol, a potent form of estrogen. The shift in your hormone balance, more estrogen, and relatively less androgen, may trigger unwanted breast tissue growth.

   You may notice symptoms like swelling, tenderness, or visible enlargement of one or both breasts. The risk of gynecomastia may be even higher if you’re overweight or have naturally high aromatase activity.

4. Mood Instability and Anxiety

   DHEA acts as a neurosteroid, meaning it directly affects your brain’s chemical signaling. When you take DHEA supplements, it may reduce the activity of GABA (a calming neurotransmitter) and increase the levels of excitatory neurotransmitters (like glutamate and dopamine). The shift may overstimulate your nervous system, making you feel edgy, restless, or anxious.

   As DHEA crosses the blood-brain barrier, these mental effects may occur even if your serum testosterone levels stay normal. In some cases, especially if you have a history of mood disorders, DHEA supplementation may even trigger panic attacks or emotional mood swings.

5. Insomnia or Sleep Disturbances

   Taking DHEA formulations, especially in the evening, may disrupt your natural sleep-wake cycle. DHEA influences adrenal hormones like cortisol, which typically follow a daily circadian rhythm. When DHEA raises cortisol levels at night, it may confuse your body’s internal clock and keep you feeling alert when you should be winding down. DHEA supplementation may also interfere with melatonin production by affecting the pineal gland function, making it harder for you to fall asleep.

   DHEA supplements may activate stimulating brain chemicals, including neurosteroids that reduce calming GABA signals. The shifts may disturb deep sleep stages and reduce the quality of REM sleep. Over time, these effects may lead to chronic sleep issues, leaving you feeling tired, irritable, and hormonally imbalanced due to poor overnight recovery.

6. Reduced HDL Cholesterol

   DHEA supplementation may lower your HDL cholesterol levels, often called the “good” cholesterol. It happens because DHEA acts like a weak androgen, and androgens may interfere with how your liver processes fats. Specifically, DHEA may decrease the production of apolipoprotein A-I, a vital protein that helps form HDL particles. With less of this protein, your HDL levels may drop, weakening your body’s ability to carry cholesterol away from arteries, a process known as reverse cholesterol transport. Over time, reduced HDL cholesterol may raise your risk of developing heart disease or cardiovascular issues.

7. Headaches and Dizziness

   DHEA supplements may influence nitric oxide production and alter endothelial function, which might contribute to sudden changes in cerebral blood flow. It may result in dizziness or lightheadedness, especially when standing up quickly. DHEA supplements may act on the brain’s autonomic centers, which influence blood pressure. This may cause temporary instability in how your body maintains balance and circulation. Hormonal shifts triggered by DHEA formulations may further upset your sodium and potassium levels, two electrolytes vital for stable nerve function. When these electrolyte levels fluctuate, your nervous system may become overactive, leading to headaches or a sensation of pressure in the head.

How Did We Evaluate The Best DHEA Supplements For Men?

1. Brand Reputation

   When evaluating the best DHEA supplements for men, brand reputation played a major role in our assessment. We looked for Better Business Bureau (BBB) ratings to learn about brand reputation, followed by Trustpilot reviews for added insights into real customer experiences.

   Among the seven brands reviewed, Vitacost held an “A+” rating and BBB accreditation on the Better Business Bureau platform, although Vitacost had an unclaimed profile on Trustpilot. Pure Encapsulations received an “A-” rating on BBB, with various complaints filed against the business. However, the brand had an unclaimed profile on Trustpilot.

   It is followed closely by Horbäach with an “A-” BBB rating due to the length of time the business has been operating. Horbäach also has an unclaimed profile on Trustpilot. Moreover, Nutricost is a BBB-accredited brand and holds a “B+” rating, with complaints filed against the brand indicating a need for improvement in customer service.

   Trustpilot reviews revealed more variation. For instance, Toniiq received a 3.8 rating out of 5 from over 25+ reviews, suggesting a generally positive customer experience, even though Toniiq lacks a BBB listing. Meanwhile, Puritan’s Pride holds a 1.4 out of 5 rating based on 275+ reviews on Trustpilot, although the brand has no listing on BBB.

   Similarly, GNC has a 1.3 out of 5 rating based on 215+ reviews on Trustpilot while lacking a brand page on the BBB platform. Brands with strong BBB records and minimal complaints earned higher trust in our selection process, while those lacking third-party accountability or facing consistently poor feedback were rated lower.

2. Price and Value

   When evaluating the best DHEA supplements for men, we closely examined each formulation’s pricing with the quantity and dosage provided to determine the overall value for money.

   Puritan’s Pride – DHEA 50 mg offers three bottles (each with 100 tablets) for $17.99 under a Buy 1 Get 2 Free deal. It brings the cost down to around $5.99 per bottle. It is followed closely by Vitacost – DHEA 25 mg Capsules, which provides one bottle (100 capsules) for $6.99.

   Nutricost – DHEA Capsules (25 mg) are priced at $10.97 for a 120-capsule bottle, which works out to approximately $0.09 per 25 mg DHEA serving. Meanwhile, Horbäach – DHEA 100 mg Capsules offer 200 capsules per bottle, which is priced at $18.98. In the mid-premium tier, Toniiq’s DHEA 99% offers one bottle (180 capsules) for $27.74.

   GNC’s DHEA Supplement offers one bottle, which provides 90 tablets at a one-time purchase price of $14.99, equating to a per-tablet cost of around $0.17.

   However, Pure Encapsulations’ DHEA 25 mg offers the most expensive option by providing one bottle (with 60 capsules) for $19.60, equating to a cost of $0.33 per 25 mg capsule.

Frequently Asked Questions

1. Do Liquid or Spray DHEA Supplements Work Better Than Capsules?
   Maybe. Liquid or spray (including sublingual) DHEA supplements may offer faster DHEA absorption by bypassing first-pass liver metabolism, which could be helpful if you have digestive issues or need rapid effects. However, more research is needed to determine if one form is consistently superior, so the choice often depends on your preference and tolerance.
2. Can DHEA Supplementation Help Men With Adrenal Fatigue?
   DHEA supplementation may support hormone balance in men with low levels, but it might not be helpful in managing adrenal fatigue symptoms like fatigue, brain fog, or sleep issues, and may cause hormonal side effects.
3. Why Do Some Brands Combine DHEA With Pregnenolone?
   Some brands may pair DHEA formulations with pregnenolone because both are hormone precursors produced by the adrenal glands that support hormonal balance, cognitive function, and stress resistance. The pairing is often customized based on specific hormone levels and symptoms to optimize therapeutic effects under medical supervision.
4. Can DHEA Supplements Interact With Medications?
   Yes, DHEA formulations may interact with some medications, including those affecting liver enzymes (like CYP3A4 substrates), hormone therapies (such as estrogen or testosterone), antidepressants, and blood thinners. It is advisable to consult a doctor before pairing DHEA formulations with any medications to minimize the risk of potential drug interactions.

Final Word

DHEA supplementation may potentially help raise testosterone levels and support hormonal balance in men. These hormonal effects might help support muscle mass maintenance, promote fat oxidation, and contribute to better mood and cognitive function.

However, DHEA may directly impact the body’s endocrine system, which means unsupervised use of DHEA formulations may trigger symptoms of hormonal imbalances that may overshadow any intended benefits. These signs may include fatigue, irregular heartbeat, mood swings, an increased urgency to urinate, or gynecomastia.

Moreover, factors like genetics, baseline hormone levels, age, diet, and tolerance to DHEA may influence how your body will respond to DHEA supplementation. Given the variability in DHEA responses and the potential risk of hormonal side effects, it is advisable to get periodic hormonal testing when taking DHEA supplements.

There are also some natural tips to support your hormonal health that might complement or even minimize the need for DHEA formulations. For instance, engaging in regular resistance training (at least 3–4 times per week) may boost endogenous testosterone and DHEA levels by stimulating endocrine function. Ensuring 7–9 hours of quality sleep daily may also support the natural circadian rhythm of hormone release, including DHEA and cortisol balance.

Consuming zinc-rich foods like pumpkin seeds, oysters, and lean meats may support testosterone and DHEA synthesis. Healthy fats present in avocados and fatty fish may provide essential building blocks for androgen production. Some herbal adaptogens like ashwagandha and rhodiola rosea may modulate the hypothalamic-pituitary-adrenal (HPA) axis, improving stress resilience and indirectly supporting balanced DHEA and cortisol levels.

Prioritizing natural lifestyle interventions alongside careful DHEA supplementation might help you achieve hormonal balance more safely and sustainably.