Published On By Rachel Nall

CoQ10, or Coenzyme Q10 supplements, could help in energy production and reduce oxidative stress. However, as you age or experience stress and certain health conditions, your CoQ10 levels might decrease, which may lead you to turn to supplements to help maintain or boost these levels. These supplements are linked to a variety of health benefits, such as supporting heart health, regulating blood sugar, rejuvenating the skin, and managing migraines.

Taking CoQ10 supplements could support your heart health by boosting energy production in heart cells and decreasing inflammation. They may also help manage your blood pressure, enhance exercise performance, improve skin elasticity, and protect brain cells from oxidative damage, potentially boosting your cognitive function and reducing mental fatigue.

With so many supplement options available, it can be overwhelming to choose the right one. You should consider the form, dosage, and quality of the CoQ10 product.

This article explores the 10 best CoQ10 supplements in 2025, highlighting their features, benefits, and potential drawbacks. We have also shared some helpful tips that can help you choose the right product as per your health needs.

What Is CoQ10 Supplement?

CoQ10, or Coenzyme Q10, is found in the mitochondria of your cells. It could help produce adenosine triphosphate (ATP), which is said to power cellular functions and might help protect your cells from oxidative stress.

While your body usually maintains sufficient levels of CoQ10, factors like aging, chronic illnesses, and certain medications, such as statins, may reduce its production, making supplementation essential for you.

CoQ10 products come in two ubiquinone and ubiquinol forms. Ubiquinone is the oxidized form commonly found in supplements, while ubiquinol is the reduced form. Ubiquinol is easier for your body to absorb and use, which means it could be more effective in supporting your health.

Research suggests CoQ10 could support your cardiovascular health, improve energy production, and reduce oxidative damage, particularly if you have heart issues, high blood pressure, or neurodegenerative conditions. Taking CoQ10 at a dose of 200 mg per day or more for a long period is said to be safe and usually well-tolerated.

However, CoQ10 may cause mild gastrointestinal issues like nausea, diarrhea, or stomach upset, and it might interfere with blood thinning medications, reducing their effectiveness.

10 Best CoQ10 Supplements In 2025

  1. Thorne CoQ10

    Thorne CoQ10

    According to the official website, Thorne CoQ10 could help support your heart, brain, and immune system, as well as promote healthy aging and energy production. It is said to use CoQ10 in its ubiquinone form, which may support your body’s energy production at the cellular level.

    Thorne CoQ10 might boost your energy levels and improve your stamina during exercise by supporting cellular energy. It may also help maintain a healthy heart by supporting normal heart rhythm, blood vessel function, and healthy blood pressure.

    Thorne CoQ10 might help protect you against oxidative stress by boosting the activity of glutathione, your body’s main antioxidant. It could also support a healthy inflammatory response.

    As per the official website, Thorne CoQ10 contains soy monoglycerides (from soy), which may cause an allergic reaction if you are sensitive to soy.

    Pros & Cons

    Pros

    • Thorne CoQ10 may support your cellular energy production.
    • It could promote a healthy heart by supporting normal heart rhythm, blood vessel function, and healthy blood pressure.
    • Thorne CoQ10 might enhance mitochondrial function.
    • The ubiquinone form of CoQ10 in this product could be well-absorbed.
    • The flaxseed oil included in the formula may provide you with omega-3 fatty acids.

    Cons

    • If you’re allergic to soy, the soy monoglycerides in this product could cause digestive discomfort.
    • You may need to take 1-2 gelcaps daily, which might not be convenient for you.
    • It contains gelatin, which makes it unsuitable for you if you are vegetarian.
  2. Garden Of Life Raw CoQ10

    Garden Of Life Raw CoQ10

    As per the official website, Garden of Life Raw CoQ10 may support your heart health and energy production. Each serving is said to give you 200mg of CoQ10, which might help your body produce energy at the cellular level.

    Garden of Life Raw CoQ10 is said to use a delivery system with RAW cold-pressed chia seed oil, which is high in omega 3-6-9, to help your body absorb it better. It may also provide you with antioxidant support to help you fight free radicals.

    According to the makers, Garden of Life Raw CoQ10 includes live probiotics like Lactobacillus plantarum and Lactobacillus bulgaricus, which may help with digestion. With no fillers or binders, Garden of Life Raw CoQ10 is said to be gluten-free, kosher, and non-GMO Project Verified.

    Pros & Cons

    Pros

    • You get 200mg of CoQ10 per serving, which may support cellular energy production.
    • The special lipid delivery system with cold-pressed chia seed oil may improve absorption.
    • Provides potent antioxidant support to help fight free radicals in your body.
    • Includes live probiotics (Lactobacillus plantarum and Lactobacillus bulgaricus) that could aid digestion.
    • No binders, fillers, gluten, or GMOs, making it a clean and pure formula.
    • It’s Kosher-certified and Non-GMO Project Verified, ensuring higher quality.

    Cons

    • The chia seed oil might not be suitable for you if you have seed allergies.
    • The 200mg of CoQ10 could be higher than what you need, depending on your specific requirements.
  3. Qunol Liquid CoQ10

    Qunol Liquid CoQ10

    Qunol manufactures Liquid CoQ10 which claims to help maintain healthy blood pressure levels and also support your heart health. It is a liquid formula that dissolves in both water and fat, helping your body absorb it better.

    According to the official website, each Qunol Liquid serving provides CoQ10 in the form of ubiquinone, along with monk fruit juice concentrate and other ingredients that help with absorption. It is also said to be free of starch, sugar, soy, yeast, wheat, and milk. If you’re taking statin medications, Qunol Liquid CoQ10 might help replace the CoQ10 that can be lost due to statin use.

    Pros & Cons

    Pros

    • Its patented liquid formulation may improve absorption.
    • It could help maintain healthy blood pressure.
    • It may help replenish CoQ10 lost from statin medications.
    • Contains no soy, wheat, yeast, milk, or starch, making it a good option for various dietary restrictions.
    • It comes in liquid form that can be easier to swallow than pills or capsules.

    Cons

    • You might not like the taste since it contains monk fruit juice concentrate.
    • If you prefer tablets or capsules, you might find the liquid form inconvenient.
    • It is only available in one liquid flavor.
  4. Life Extension Super Ubiquinol CoQ10

    Life Extension Super Ubiquinol CoQ10

    Manufactured by Life Extension, Super Ubiquinol CoQ10 provides you with 100 mg of bioavailable ubiquinol CoQ10, which may help keep your blood levels of CoQ10 healthy. It could also support your heart health, boost your cell energy, and help protect your body from oxidative stress.

    As per the official website, Life Extension Super Ubiquinol CoQ10 may help protect essential proteins and mitochondrial DNA from damage. It might help fight general fatigue, support your liver, and reduce inflammation. Life Extension Super Ubiquinol CoQ10 is also said to be gluten-free and non-GMO.

    Pros & Cons

    Pros

    • It could help keep your cardiovascular system healthy.
    • It may reduce feelings of fatigue by supporting energy production.
    • It is non-GMO and gluten-free.
    • It comes with a 365-day guarantee.
    • It uses the Kaneka form of Ubiquinol.

    Cons

    • If you have difficulty swallowing capsules, the softgel form may be a challenge.
    • It tends to be more expensive than other CoQ10 forms.
    • You might experience mild stomach upset or other digestive issues.
  5. Luma Nutrition CoQ10

    Luma Nutrition CoQ10

    Luma Nutrition’s CoQ10 claims to help improve your heart health, balance your blood sugar levels, and boost your energy. It is said to be made in the USA, in an FDA-registered, GMP-certified facility and is tested by a third-party lab to make sure it’s pure and the correct dosage is used.

    The makers highlight that Luma Nutrition CoQ10 could help improve circulation throughout your body, which might increase your endurance and overall performance. It might also support your body in turning food and oxygen into energy.

    Pros & Cons

    Pros

    • It comes with a 90-day return policy, allowing you a risk-free purchasing experience.
    • It offers free standard shipping on all U.S. orders over $65.
    • Luma Nutrition CoQ10 has undergone third-party testing to ensure quality and proper dosage.
    • It gives you 400mg per day, which may help with better glycemic control.
    • Luma Nutrition CoQ10 is manufactured in an FDA-registered, GMP-certified facility.

    Cons

    • The use of gelatin can be unsuitable for you.
    • While it’s relatively affordable, you may find competing brands offer better value or higher bioavailability for a similar price.
    • Limited shipping availability if you’re outside the U.S.
  6. Nootropic Depot Coenzyme Q10 Powder

    Nootropic Depot Coenzyme Q10 Powder

    Nootropic Depot Coenzyme Q10 Powder claims to help reduce physical fatigue, increase your energy, and improve your exercise performance. It may also help you recover faster after working out.

    As per the official website, Nootropic Depot Coenzyme Q10 Powder comes in 15g or 30g jars. It is made in the USA in FDA-registered, cGMP-certified facilities using third-party ISO-accredited labs.

    Nootropic Depot Coenzyme Q10 Powder might support your circulation and heart health. It could also improve your mental sharpness and focus, giving you more mental energy throughout the day.

    Pros & Cons

    Pros

    • It’s lab-tested for purity and identity, ensuring high quality.
    • Made in the USA in FDA-registered, cGMP-certified facilities.
    • It might help increase your energy levels and improve your exercise capacity.
    • Available in both 15- and 30-gram quantities, which makes it easier to choose the size that best suits your usage.

    Cons

    • The powder form might be less convenient for you if you prefer capsules or tablets.
    • You might not like the taste or texture of the powder.
    • You’ll need to measure your dosage, which could be less convenient than pre-measured pills.
  7. Doctor’s Best High Absorption CoQ10 Supplement

    Doctor's Best High Absorption CoQ10 Supplement

    As per the official website, Doctor’s Best High Absorption CoQ10 could boost energy production and support your heart health. It is said to contain 100 mg of naturally fermented, pharmaceutical-grade CoQ10 combined with BioPerine, a natural black pepper extract that may enhance absorption and bioavailability.

    Doctor’s Best High Absorption CoQ10 claims to help restore your body’s CoQ10 levels, potentially improving cardiovascular health and protecting your heart. It could also support energy production within your mitochondria, which may support better energy creation and delivery throughout your body.

    Pros & Cons

    Pros

    • You get 100 mg of CoQ10 per serving, which could support your heart health and boost energy production.
    • The addition of BioPerine (black pepper extract) might help improve absorption and make the CoQ10 more effective for you.
    • It’s naturally fermented and pharmaceutical-grade, ensuring a high-quality formula.
    • It could help restore your CoQ10 levels, potentially improving cardiovascular and cellular function.

    Cons

    • The 100 mg dosage might be lower than what you need for optimal results.
    • If you’re sensitive to black pepper, you may experience mild digestive discomfort due to BioPerine.
    • The results could take some time to show, and you might experience slower effects compared to others.
  8. Nature’s Bounty CoQ10

    Nature's Bounty CoQ10

    Nature’s Bounty CoQ10 is available in 200 mg Softgels, which may help support your heart health and give your body more energy. It could help replace CoQ10, which might be lost from taking statin medications.

    The makers state that Nature’s Bounty CoQ10 might help convert your food into energy for your cells, which helps fuel your body. It is said to contain Q-Sorb, which may help fight free radicals that may cause harm to your cells. This could help slow down the aging of your cells.

    Nature’s Bounty CoQ10 is free of GMOs, sugar, gluten, lactose, and artificial flavors or sweeteners, making it a suitable choice if you have specific dietary preferences.

    Pros & Cons

    Pros

    • Taking Nature’s Bounty CoQ10 may help support your heart health.
    • It could help increase your energy levels.
    • The Q-Sorb ingredient may decrease oxidative stress.
    • It’s free from GMOs, gluten, sugar, lactose, and artificial flavors.

    Cons

    • The softgels are made with gelatin.
    • You might find Nature’s Bounty CoQ10 expensive as compared to other CoQ10 products.
  9. ZEBORA CoQ10

    ZEBORA CoQ10

    ZEBORA CoQ10 could support your heart health and immune system and improve your tissue health. It contains 60 mg of omega-3s per softgel, which could help improve your sleep and support your brain, eyes, and skin.

    According to the makers, ZEBORA CoQ10 also includes PQQ (Pyrroloquinoline quinone), which may boost energy production in your cells and help your heart function better. It has BioPerine, a natural black pepper extract that could help your body absorb the nutrients more effectively.

    ZEBORA CoQ10 is said to be third-party tested for quality and purity and is made in a cGMP-certified facility.

    Pros & Cons

    Pros

    • It’s free from sugar, starch, milk, lactose, wheat, yeast, and sodium.
    • The formula contains omega-3s and PQQ.
    • It’s third-party tested for quality and purity.
    • Manufactured in a cGMP-certified facility.
    • The BioPerine in the formula might enhance nutrient absorption.

    Cons

    • The softgels are made with bovine gelatin.
    • You need to refrigerate the product to maintain its freshness.
    • The omega-3s might leave a fishy aftertaste.
  10. Puritan’s Pride CoQ10

    Puritan's Pride CoQ10

    According to the creators, Puritan’s Pride CoQ10 provides 600mg of Coenzyme Q10 in every softgel, which could help support your immune function, maintain healthy blood pressure, and promote healthy aging. It might also help boost your energy by supporting energy production and protecting your cells from harmful free radicals.

    Puritan’s Pride CoQ10 might also help improve circulation and blood vessel function, contributing to normal blood pressure levels and overall cardiovascular health. It could also help reduce fatigue and support your body’s ability to recover after intense activity by supporting your heart’s energy production.

    Pros & Cons

    Pros

    • It is said to contain 600mg of CoQ10 per softgel.
    • It may support heart health by improving circulation and blood vessel function.
    • It is said to be free from artificial flavors, sweeteners, preservatives, gluten, wheat, or dairy.

    Cons

    • 600mg per softgel might be a high dose for you.
    • Softgel form may not be suitable if you prefer liquid or have difficulty swallowing capsules.
    • Its higher dose might cause mild digestive discomfort or upset stomach.

Health Benefits Of CoQ10 Supplements

  1. It Could Support Cardiovascular Health

    CoQ10 supplements could support the electron transport chain within mitochondria, which is essential for ATP production in heart cells. This process may help ensure that your heart receives the energy it requires to pump blood effectively. CoQ10 may support improved myocardial function and help reduce the risk of cardiovascular problems by enhancing ATP production. It could also assist in the maintenance of endothelial cell function, which helps improve blood vessel elasticity and overall circulation.

  2. It Might Promote Healthy Blood Pressure

    Taking CoQ10 products may contribute to healthy blood pressure by supporting the endothelium, the thin layer of cells that line blood vessels. CoQ10 could improve endothelial function and help promote the relaxation of blood vessels, reducing vascular resistance. This relaxation might help the blood flow more easily, which may contribute to a balanced blood pressure level.

  3. It Could Enhance Exercise Performance and Stamina

    CoQ10 products could help optimize mitochondrial function, leading to more efficient ATP production during exercise. With enhanced ATP synthesis, your muscles can sustain higher levels of performance and recovery. Including CoQ10 in your routine may also help reduce lactate buildup in your muscles, which can delay fatigue during prolonged or intense physical activity.

  4. It May Protect Cells From Oxidative Stress

    Consuming CoQ10 supplements could help neutralize free radicals and reduce oxidative damage to proteins, lipids, and DNA. This protection might help maintain cellular integrity and function, which is especially important in high-energy organs like the heart and brain. CoQ10’s role in protecting against oxidative stress may help reduce the chances of chronic conditions such as cardiovascular disease and neurodegenerative diseases.

How To Choose The Best CoQ10 Supplements?

  1. Form And Dosage Of CoQ10

    When choosing the best CoQ10 supplement, you could consider its form, ubiquinone or ubiquinol. Ubiquinone is common, but ubiquinol is easier for your body to absorb, which may make it more effective. If you’re older or have certain health conditions, your body may struggle to convert ubiquinone to ubiquinol, so you might want to choose ubiquinol for better absorption.

    Also, you should check the dosage. A typical dose ranges from 100 mg to 200 mg per day, but this could vary depending on your specific needs. You must look at the label for any added ingredients, especially if you’re avoiding certain allergens or additives. However, remember that taking too much CoQ10 could cause stomach discomfort or other problems. Start with a lower dose to notice how your body reacts, and adjust it if needed.

  2. Bioavailability And Absorption

    CoQ10 is a fat-soluble compound, meaning it’s absorbed better when taken with fat. To help your body absorb it fully, try taking it with a meal that combines healthy fats such as avocado, nuts, or olive oil. The way your body absorbs CoQ10 can also depend on the form you take, whether it’s ubiquinone or ubiquinol, and how the product is made.

    Some brands also add ingredients like piperine (from black pepper) to improve CoQ10’s absorption. It also comes in soft gels or liquid forms that tend to be better absorbed than tablets or capsules, as they dissolve more easily in your digestive system.

    If you are looking for a highly effective supplement, consider one that specifically highlights its enhanced bioavailability or absorption mechanisms. You can also choose CoQ10 products that are formulated with oils, as that could potentially help improve fat-soluble absorption.

  3. Purity And Quality

    To check the purity and quality of CoQ10 products, check if they have been tested for purity, free from fillers, additives, and contaminants. Look if the makers mention the ingredients clearly on the label, as it will ensure that the CoQ10 content is high and not diluted with unnecessary substances.

    Also, check for certifications or third-party testing. Reputable brands will often provide certificates of analysis to confirm that the product meets quality standards. Choosing a product from a trusted manufacturer ensures you’re getting a formula that’s both effective and safe. To get the most benefit, choose CoQ10 products that use high-quality, bioavailable forms like ubiquinol. This makes sure your body can absorb and utilize the CoQ10 more effectively.

  4. Manufacturing Standards

    Look for CoQ10 products made by companies that follow Good Manufacturing Practices (GMP). These guidelines ensure that products are produced to meet high-quality standards. GMP-certified manufacturers test their products for strength, purity, and safety, making these products more reliable. Some companies go further by using cGMP-certified facilities and sourcing their raw materials responsibly. You can ensure your product’s safety and effectiveness by choosing a CoQ10 formula from a reputable manufacturer that follows these standards.

  5. Reviews And Reputation

    Before purchasing, make sure to research the CoQ10 product and read feedback from users who have similar health goals or concerns. Analyzing positive reviews can give you an overview of the quality and efficacy of the formula, while negative reviews may highlight potential issues such as low bioavailability, side effects, or poor customer service.

    You should consider supplements from reputable brands that are known for their commitment to quality and transparency. A strong reputation in the industry, along with consistent positive feedback from users, may support brand reliability.

How Does CoQ10 Supplement Work?

CoQ10 is found in the mitochondria, the part of your cells that helps turn food into energy. It is said to help move electrons through the electron transport chain, which is how your body creates adenosine triphosphate (ATP), the energy your body uses.

CoQ10 also works as an antioxidant, protecting your cells from damage caused by free radicals. It might help keep your cells healthy and functioning well by neutralizing free radicals, especially in organs like your heart. Taking CoQ10 products may help improve energy production, support heart health, and even slow down some signs of aging.

While CoQ10 supplements may provide benefits, the results could vary. High doses of CoQ10 may also cause side effects like stomach upset, nausea, or diarrhea.

Potential Side Effects Of CoQ10 Supplements

  1. Mild Digestive Issues

    You might experience mild digestive discomfort when taking CoQ10 supplements. This could happen because your body is adjusting to higher doses of CoQ10, which can sometimes irritate your stomach lining. Since CoQ10 is fat-soluble, taking it on an empty stomach may make digestive issues like nausea, bloating, diarrhea, or indigestion more likely.

  2. Dizziness Or Lightheadedness

    If you feel dizzy or lightheaded after taking CoQ10, it may be due to its effect on your blood pressure. It could lower your blood pressure, especially if it’s already on the lower side. This can decrease the amount of oxygen reaching your brain, which might cause dizziness or faintness. You might experience a sense of unsteadiness, a spinning sensation, or feel lightheaded, especially when standing up too quickly.

  3. Headaches

    CoQ10 products could cause headaches as they may affect your blood flow. It is said to support mitochondrial function and energy production, which may lead to changes in circulation or blood pressure. This change might trigger a headache, especially if you’re sensitive to fluctuations in vascular tone. You could also feel a dull ache or sharp pain, typically in the head or temples.

  4. Insomnia Or Trouble Sleeping

    Taking CoQ10 may make it harder for you to fall asleep, especially if you take it late in the day. Since it boosts cellular energy production, it could increase your alertness, making it difficult to relax. You might also experience restlessness, difficulty falling asleep, or waking up frequently throughout the night.

  5. Fatigue Or Feelings Of Weakness

    While CoQ10 is generally taken to boost energy, you may experience fatigue or weakness. This could be due to your body adjusting to the formula, as the mitochondria take time to optimize energy production. You might feel unusually tired, sluggish, or weak and experience a lack of motivation or muscle weakness during this period.

  6. Interactions With Blood Thinners Or Medications

    If you’re on blood thinners like warfarin, CoQ10 might interact with these medications. Since CoQ10 has a structure similar to vitamin K, it could reduce the effectiveness of your blood-thinning medication, making it harder for your body to prevent blood clots. This could lead to symptoms like bruising, bleeding, or a longer time to stop bleeding after cuts.

Frequently Asked Questions

  1. Can I Take CoQ10 With Other Supplements?
    You can take CoQ10 with other supplements, such as vitamins E and C or omega-3s. However, be cautious if you’re on blood thinners like warfarin, as CoQ10 may increase blood clotting risk. Make sure to stay mindful of dosages and consult your healthcare professional to avoid potential interactions.
  2. What Foods Naturally Contain CoQ10?
    You’ll find CoQ10 naturally in foods like fatty fish, organ meats, spinach, broccoli, and whole grains. Including these items in your diet can help boost your CoQ10 levels and support your overall health.
  3. Can CoQ10 Help With Fatigue?
    CoQ10 may help improve your energy levels by supporting the production of ATP, the energy your cells need. It’s especially beneficial if you’re feeling fatigued due to low CoQ10 levels or certain health conditions.

Conclusion

CoQ10 supplements could offer you significant benefits, such as boosting your energy levels, supporting heart health, and reducing oxidative stress. It might help improve your cell function and vitality, especially in energy-demanding areas like the heart and muscles.

If you want to enhance your CoQ10 levels, we have shared the 10 best CoQ10 supplements in 2025 that may help support your energy levels.

For optimal results, you may also consider combining CoQ10 with natural approaches like eating a balanced diet rich in healthy fats, staying active, and managing stress. These lifestyle changes can enhance your heart health and stamina, helping you achieve the best outcomes.

Disclaimer
  • The information in this guide is for informational purposes only and should not be considered medical advice.
  • It is not recommended to disregard/delay seeking professional medical advice or treatment because of what you read or accessed through this guide.
  • The results may vary from individual to individual.
  • Consult your doctor for any underlying medical conditions or if you are on any prescribed medicines before trying any product.

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