10 Best Alpha-Lipoic Acid Supplements In 2025

ALA is an antioxidant that might help support nerve health, blood sugar control, and metabolic health. Supplementing with alpha-lipoic acid supplements may support weight management and also help with fat loss.

However, with so many options on the market, choosing the right supplement can be overwhelming. Some ALA supplements may offer better absorption, while others might contain higher-quality ingredients or fewer additives.

A helpful guide could save you time, money, and guesswork by pointing out which products stand out and why. In this guide, we discuss the 10 best Alpha-Lipoic Acid supplements based on quality, value, and purity.

What is Alpha-Lipoic Acid?

Alpha-lipoic acid (ALA) plays a critical part in energy metabolism, particularly in the mitochondria, the part of the cell responsible for producing energy.

ALA functions as a coenzyme in the citric acid cycle (also called the Krebs cycle), which is central to converting glucose into usable energy.

Although the body makes small amounts of ALA on its own, dietary sources such as spinach, broccoli, organ meats (like liver), and potatoes provide additional amounts. However, the levels obtained from food are relatively low, which promotes the need for ALA supplements for potential therapeutic benefits.

ALA is unique because it is both water- and fat-soluble. This dual solubility allows it to work in all parts of the cell and interact with antioxidants, like coenzyme Q10, vitamins C and E, and glutathione. ALA’s antioxidant properties may combat oxidative stress, which is linked to cardiovascular issues and neurodegenerative disorders.

10 Best Alpha-Lipoic Acid Supplements

1. Nutricost Alpha Lipoic Acid

   

   Nutricost Alpha Lipoic Acid provides a potent dose of ALA in a clean, vegetarian-friendly formula. As per the official website, each Nutricost Alpha Lipoic Acid bottle contains 240 capsules, providing 120 to 240 servings depending on your chosen dosage.

   Nutricost Alpha Lipoic Acid offers 600 mg of Alpha Lipoic Acid per serving (300 mg per capsule). It is said to be non-GMO, gluten-free, soy-free, and made with vegetarian capsules.

   The makers state that Nutricost Alpha Lipoic Acid is also rigorously third-party tested to ensure quality, safety, and potency. This formula may support mitochondrial energy metabolism, and its antioxidant activity could support healthy nerve function, combat oxidative stress, and help manage blood sugar levels.

   Produced in a GMP-compliant and FDA-registered facility in the USA, Nutricost Alpha Lipoic Acid maintains high manufacturing standards, ensuring consistency and trust.
   

   Pros

   • Available in capsule form, which is easy to swallow due to its slippery texture.
   • Could help promote skin health and may reduce signs of aging.
   • Might support cognitive function and protect brain cells

   Cons

   • May cause insomnia or disrupt sleep in some people.
   • Potential to cause gastrointestinal irritation or discomfort in sensitive users.

2. BulkSupplements Alpha Lipoic Acid

   

   According to the official website, BulkSupplements Alpha Lipoic Acid is available in powder form. It could support energy production in cells while helping to neutralize harmful free radicals.

   The makers state that BulkSupplements Alpha Lipoic Acid may help support cellular energy production. It might support mitochondrial function, where it may help in breaking down carbs and fats into energy. This function is vital for maintaining physical stamina and reducing fatigue, especially for people with demanding lifestyles or those engaged in regular exercise. BulkSupplements Alpha Lipoic Acid could also support cognitive health. It might help promote sharper focus, mental clarity, and memory retention by decreasing oxidative stress in the brain.

   As per the official website, BulkSupplements Alpha Lipoic Acid powder is easy to use and can be added to water, juice, or smoothies.
   

   Pros

   • Available in powder form, offering flexible consumption options.
   • Could support antioxidant activity, helping protect cells from oxidative stress.

   Cons

   • Powder form may have a strong or unpleasant taste, requiring mixing with strong-flavored beverages.
   • May require precise measuring tools to ensure correct dosing, which may be inconvenient.

3. Thorne Alpha-Lipoic Acid

   

   Thorne’s Alpha-Lipoic Acid supplement delivers 300 mg of alpha-lipoic acid in each vegetarian capsule. It could help protect various tissues in your body from oxidative stress, particularly the nervous system and liver.

   As per the makers, Thorne’s Alpha-Lipoic Acid might support liver detoxification, helping your body remove harmful substances efficiently. It could also contribute to maintaining healthy nerve function.

   Thorne’s Alpha-Lipoic Acid might help support cognitive functionby reducing oxidative stress, which is known to affect brain health over time negatively. It may also help maintain mental clarity and enhance your brain performance by neutralizing free radicals.

   According to the official website, Thorne’s Alpha-Lipoic Acid could help recycle glutathione, as well as other antioxidants like vitamins C and E. This recycling action helps maintain your antioxidant defenses, promoting a stable inflammatory response throughout the body.

   Thorne’s Alpha-Lipoic Acid contains a natural 50:50 mix of the r-lipoic acid and s-lipoic acid isomers, ensuring you get the full spectrum of benefits from this vital antioxidant.
   

   Pros

   • Could support your neurological health and nerve protection.
   • May promote cognitive sharpness and mental clarity.
   • Might support mitochondrial function, aiding cellular energy production.

   Cons

   • Potential risk of lowering thiamine levels if combined with excessive alcohol intake.
   • The product price could be higher compared to other similar alpha-lipoic acid supplements.

4. NatureBell Alpha Lipoic Acid

   

   According to the official website, NatureBell’s Alpha Lipoic Acid features a Myelinctin™ delivery system to boost absorption in both water- and fat-based tissues.

   NatureBell’s Alpha Lipoic Acid uses a 4-in-1 blend including 300 mg R-Alpha Lipoic Acid, 300 mg S-Alpha Lipoic Acid, 100 mg Thiamine Mononitrate, and 25 mg Benfotiamine.

   R-ALA could support superior cellular uptake, while thiamine and benfotiamine, both forms of vitamin B1, play key roles in mitochondrial energy production and nerve signaling. This combination may enhance NatureBell’s Alpha Lipoic Acid’s ability to regenerate other antioxidants and support healthy tissue function throughout the body. This formula could help support energy metabolism, maintain nerve and immune health, and protect cells from oxidative stress.
   

   Pros

   • Contains 600 mg of Alpha Lipoic Acid per serving, a potent dose for antioxidant support.
   • Might decrease the appearance of fine lines and wrinkles.
   • May improve memory and cognitive function.

   Cons

   • Capsules are relatively large, which may be difficult for some people to swallow.
   • Potential for allergic reactions or skin rash in sensitive people.

5. Pure Encapsulations Alpha Lipoic Acid

   

   Pure Encapsulations Alpha Lipoic Acid may provide antioxidant and metabolic support. It might help bridge the gap between energy production and cellular protection.

   As per the official website, Pure Encapsulations Alpha Lipoic Acid may support mitochondrial energy generation, help convert calories into usable energy, and contribute to the optimal metabolism of glucose.

   Pure Encapsulations Alpha Lipoic Acid might also support nerve cell integrity and liver function, areas often vulnerable to oxidative stress.

   The makers state that each Pure Encapsulations Alpha Lipoic Acid capsule is made using synthetically produced alpha-lipoic acid with a minimum purity of 99%, ensuring consistency and effectiveness. The addition of vitamin C (ascorbyl palmitate) derived from corn dextrose fermentation in this formula may further boost antioxidant defense.
   

   Pros

   • Could support healthy glucose metabolism, aiding in blood sugar regulation.
   • May help nourish and support the nervous system, potentially offering neuroprotection.

   Cons

   • Not all users may notice immediate effects, and benefits might require long-term, consistent use.
   • Some people might find the capsules difficult to swallow.

6. American Standard Supplements Alpha Lipoic Acid

   

   American Standard Supplements Alpha Lipoic Acid (ALA) formula provides 1,300 mg of alpha-lipoic acid per two-capsule serving, which might help combat oxidative stress and promote cellular health.

   Alpha Lipoic Acid (ALA) by American Standard Supplements might also help protect your tissues and organs by reducing oxidative stress, potentially lowering the risk of diseases that are associated with inflammation and cellular damage.

   The makers state that their Alpha Lipoic Acid (ALA) supplement can help neutralize free radicals, support nerve function, promote glucose metabolism, and maintain mitochondrial energy production.

   American Standard Supplements Alpha Lipoic Acid (ALA) claims to be produced in the USA using globally sourced ingredients and is manufactured in an FDA-registered facility and tested rigorously for quality, purity, and potency.
   

   Pros

   • May support nerve health and may reduce symptoms of neuropathy.
   • Could help regenerate other antioxidants like vitamins C and E.
   • May help improve insulin sensitivity.

   Cons

   • Some people might experience heartburn or acid reflux.
   • Results could vary, and not everyone might experience the same effects.

7. Now Foods Alpha Lipoic Acid

   

   As per the official website, NOW Foods Alpha Lipoic Acid provides a 250 mg dose per capsule. It may support the recycling of other essential antioxidants like vitamin C and vitamin E, prolonging their activity and enhancing cellular defense.

   NOW Foods Alpha Lipoic Acid might also support energy production, helping in the conversion of glucose into energy, an essential process for maintaining healthy metabolic function. It might support your body’s natural production of glutathione, one of the most powerful internal antioxidants. Glutathione plays a key part in detoxifying the liver, maintaining immune function, and protecting cells from excess damage. This formula might help strengthen your body’s antioxidant defense system from the inside out by promoting its synthesis.
   

   Pros

   • May reduce symptoms of diabetic neuropathy.
   • Could support healthy nerve function.
   • May slow the progression of neurodegenerative diseases.

   Cons

   • Can deplete essential minerals such as calcium, magnesium, selenium, and iron if not balanced properly.
   • May interact with blood sugar-lowering medications, potentially causing hypoglycemia.

8. Puregen Labs Alpha Lipoic Acid

   

   Puregen Labs Alpha Lipoic Acid (ALA) provides a potent 600 mg dose of ALA in each capsule to support your body’s natural energy production and cellular health. It may support a healthy metabolism function and boost vitality.

   Puregen Labs ALA could also promote nerve health, particularly for people who experience occasional tingling or discomfort in the hands and feet. It may provide comprehensive antioxidant protection by neutralizing harmful free radicals and helping to prevent oxidative stress that contributes to aging and cellular damage.

   As per the official website, Puregen Labs is naturally vegetarian-friendly and free from gluten, wheat, milk, lactose, artificial flavors, sweeteners, synthetic dyes, and artificial colors. It’s also non-GMO and made in the USA in a facility that follows GMP guidelines.
   

   Pros

   • Might cross the blood-brain barrier to support brain health.
   • May reduce oxidative stress and support healthy energy levels.
   • Could support healthy mitochondrial function.

   Cons

   • The 600 mg dose might be too strong for some people, leading to intolerance or side effects.
   • No flavor or chewable form is available, which some consumers might find inconvenient.

9. SuperiorLabs Alpha Lipoic Acid

   

   Superior Labs Alpha Lipoic Acid may provide antioxidant protection and support your metabolic health. It contains 600 mg of alpha-lipoic acid (ALA) per capsule, a naturally occurring compound involved in energy metabolism and known for its dual solubility.

   As per the official website, Superior Labs Alpha Lipoic Acid may help promote healthy skin aging, support insulin sensitivity, and blood sugar regulation, encourage nervous system health, and aid in cognitive and kidney function. It may also contribute to a healthy inflammatory response.

   The makers advise using only one Superior Labs Alpha Lipoic Acid capsule daily, preferably under the guidance of a healthcare practitioner. It contains only three ingredients, including alpha-lipoic acid, plant cellulose (for the capsule), and organic rice extract.
   

   Pros

   • Includes vegetable capsules, suitable for vegetarians and those avoiding gelatin capsules.
   • May promote healthy aging at the cellular level.
   • Might improve endothelial function and vascular health.

   Cons

   • Some people may experience allergic reactions or skin rashes, although rare.
   • The product does not contain additional synergistic ingredients that some other ALA formulas include for enhanced effects.

10. Horbäach Alpha Lipoic Acid

    

    The Horbaach Alpha Lipoic Acid 600mg (240 Capsules) provides 600 mg of Alpha Lipoic Acid (ALA) per three capsules, which might help neutralize free radicals and support healthy cellular energy production.

    As per the official website, Horbaach Alpha Lipoic Acid also includes 999 mcg of Biotin, a B-vitamin that helps support healthy hair, skin, and nails while also aiding in energy metabolism. It is delivered in quick-release capsules, which might enhance absorption and also ensure that the nutrients are made available to the body efficiently.

    The makers claim that Horbaach Alpha Lipoic Acid is non-GMO and free from common allergens such as gluten, wheat, yeast, lactose, artificial flavors, and colors. It is laboratory-tested to ensure purity and potency.
    

    Pros

    • It may help reduce LDL (“bad”) cholesterol levels.
    • Could support healthy blood pressure regulation.
    • May enhance skin texture and firmness.

    Cons

    • Quick-release capsules may cause faster metabolism of ALA, potentially requiring more frequent dosing.
    • Not everyone may experience the same results, and the timeframe for the effects could also vary.

Side Effects of Alpha-Lipoic Supplement

1. Might Induce Stomach Pain

   Stomach pain or gastrointestinal discomfort is a commonly reported side effect of alpha-lipoic acid (ALA) supplements. This may occur because ALA, particularly in higher doses, can irritate the stomach lining or alter digestive function. Its acidic nature may stimulate excess gastric acid or disrupt the mucosal barrier, especially in sensitive individuals.

2. May Cause Low Blood Sugar

   Alpha-lipoic acid supplements can enhance insulin sensitivity and increase glucose uptake in tissues, which helps support healthy blood sugar regulation. However, this mechanism may also cause blood sugar to drop too low, particularly in people taking insulin or oral antidiabetic drugs.

   ALA activates pathways like AMPK, boosting cellular glucose transport, which can lead to symptoms of hypoglycemia such as dizziness, sweating, or confusion. If you’re using ALA supplements alongside diabetes medications, regular blood glucose monitoring is essential.

3. May Cause Fatigue

   Although ALA is involved in mitochondrial energy production, some people may experience fatigue when starting alpha-lipoic acid supplements. This may be due to temporary metabolic adjustments as your body responds to shifts in energy processing and antioxidant levels. ALA supplements could also induce improvements in insulin sensitivity, which can lower blood glucose levels, potentially leading to insufficient glucose for brain or muscle energy, resulting in tiredness or low energy.

4. May Cause Muscle cramps

   Some people may experience muscle tightness or pain after taking alpha-lipoic acid supplements, though this side effect is less frequent. ALA supports mitochondrial function and energy metabolism, but shifts in these processes, particularly glucose utilization and ATP production, can occasionally disrupt normal muscle contraction. In some cases, ALA-related hypoglycemia may also trigger cramps by reducing the availability of glucose needed for muscle function.

How Did We Evaluate The Best Alpha-Lipoic Supplement?

1. Refund Policy

   We evaluated the refund policies of these 10 Alpha-Lipoic Supplement brands to see which one prioritizes customer satisfaction and transparency.

   Nutricost offers a reasonable timeframe to evaluate the product with a 60-day full refund (excluding shipping) and no questions asked. NatureBell follows closely, also with a 60-day money-back guarantee for quality or health concerns, though return shipping is the customer’s responsibility.

   Horbäach stands out for its straightforward 30-day full refund policy, providing confidence and clarity, despite not covering shipping costs. Puregen Labs offers a clean 30-day money-back guarantee with no hidden fees, making it a good mid-tier option.

   BulkSupplements is fair for bulk buyers with a 30-day return window, full refunds for unopened items, and partial refunds for opened ones. Now Foods matches industry standards with a 30-day refund on unopened items bought directly from their website, though return shipping is on you.

   SuperiorLabs and Pure Encapsulations are more restrictive, requiring pre-approvals and charging restocking fees (15%), reducing their consumer-friendliness. Thorne’s 60-day return policy is overshadowed by a steep 25% restocking fee, significantly lowering its value.

   American Standard Supplements ranks last due to the absence of a clear refund or return policy, making it the riskiest choice for buyers.

   Thus, our evaluation revealed that the refund policies of these ALA supplements we discussed vary greatly, with some offering flexibility and clarity while others adding unnecessary constraints.

2. Value for Money

   We evaluated the cost-effectiveness of each ALA supplement to identify which brands offer the best value without compromising on quality.

   NatureBell offers the best value with 300 capsules for $26.95, costing just $0.09 per capsule. Horbäach is close behind at $19.19 for 240 capsules ($0.08 per capsule), making both suitable for long-term use.

   BulkSupplements gives unmatched value if you’re fine using powder, 100g for $19.97 can yield over 160 servings at a fraction of the cost per dose. Puregen Labs (180 capsules for $23.95) and American Standard Supplements (90 for $15.29) also offer strong value under $0.17 per capsule.

   Nutricost offers 120 capsules for $19.97 and sits mid-range at $0.17 per capsule, offering dependable quality for general use. SuperiorLabs (120 for $33.95) costs $0.28 per capsule but promotes a clean-label formula, which may justify the price if you avoid additives. Now Foods provides 60 capsules for $19.99, which is a reputable brand, though at $0.33 per capsule, it’s less competitive in price.

   Thorne (60 for $39) and Pure Encapsulations (120 for $109.40) sit at the premium end, costing $0.65 and $0.91 per capsule, respectively. While both emphasize purity and third-party testing, their high prices don’t reflect significantly better value for most users unless you have specific sensitivities.

3. Brand Reputation

   As part of our evaluation of the best Alpha Lipoic Acid supplements, we examined each brand’s reputation using third-party ratings, complaint histories, and industry credibility.

   NOW Foods stands out with a strong A+ rating from the BBBand a decades-long presence in the supplement industry, making it one of the most trustworthy brands for Alpha Lipoic Acid.

   Nutricost, with an A+ BBB rating as well, offers no-frills, affordable products, and demonstrates reliable customer service, even though it’s not widely reviewed on other platforms.

   Pure Encapsulations holds an A-ratingwith the BBB and has a good reputation among healthcare professionals, though its lack of consumer-facing reviews limits transparency.

   Horbäach, also rated A- by the BBB, shows decent customer support based on complaint handling.

   Thorne is known for premium formulations and is trusted in clinical settings, but its C+ BBB ratingand two unresolved complaints suggest weaker follow-through on the customer service side.

   BulkSupplements has a B rating from the BBB anda low 1.8-star Trustpilot score, with 39 complaints filed, pointing to ongoing issues with service and reliability.

   Nutricost and Superior Labs currently do not have a BBB rating, so it makes it difficult to assess their reputation for quality and integrity. Similarly, NatureBell, Puregen Labs, and American Standard Supplements have no listings on BBB or Trustpilot, offering no third-party accountability.

Frequently Asked Questions

1. Are alpha-lipoic acid supplements safe?
   Generally, yes. When taken as directed by the manufacturer, ALA supplements are safe for most people. However, it could cause mild side effects such as stomach discomfort or excessive blood sugar in some cases.
2. Can I stack alpha lipoic acid supplements with other supplements?
   Yes, ALA can be safely stacked with CoQ10, acetyl L-carnitine, and N-acetylcysteine (NAC). These combinations are commonly used for their synergistic antioxidant and mitochondrial support effects. However, ALA can lower blood sugar, and you should use caution when combining it with supplements or medications that affect glucose levels.
3. Can alpha-lipoic acid supplements support skin health?
   Yes, Alpha Lipoic acid’s antioxidant properties might help protect the skin cells from excessive oxidative stress, promoting healthier, more youthful skin.

Conclusion

Alpha-lipoic acid supplements may support antioxidant activity, energy metabolism, and blood sugar regulation. Their unique solubility allows ALA to work throughout the body and help regenerate other antioxidants, which may support cellular health.

However, ALA supplementation may cause side effects such as gastrointestinal discomfort, fatigue, muscle cramps, and, in some cases, low blood sugar, especially for people on glucose-lowering medications. It is advisable to consult a doctor before starting ALA supplements, particularly if you have underlying health conditions or are taking medication.

ALA is also naturally present in foods like spinach, broccoli, tomatoes, peas, Brussels sprouts, and organ meats. Including these foods in your diet may also support your body’s natural antioxidant defenses alongside supplementation.